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pro vyhledávání: '"Bo Im Choi"'
Autor:
In Ho Kim, Hye Sik Kong, Heejung Kim, Bo Im Choi, Young Mi Kim, Young-Soo Kim, Young Wook Yang, Yun Jin Jung
Publikováno v:
Drug development and industrial pharmacy. 32(3)
We synthesized dexamethasone 21-sulfate sodium (DS) as a colon-specific prodrug of dexamethasone and investigated its properties. Introduction of a sulfate group to dexamethasone lowered the apparent partition coefficient from 52.5 to 0.27 in 1-octan