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Autor:
Charalabos Pothoulakis, Kausar Ali, Hanping Feng, Tor C. Savidge, Michael J. Loeffelholz, Robert D. English, Alfredo G. Torres, Jonathan S. Stamler, Lianfa Shi, Bo Herman, Numan Oezguen, Raj Kumar, Alfred Hausladen, Weijia Nie, John E. Wiktorowicz, Vinay Acharya, Werner Braun, Petri Urvil, Iryna V Pinchuk, Aproteem Choudhury
Publikováno v:
Nature Medicine. 17:1136-1141
The global prevalence of severe Clostridium difficile infection highlights the profound clinical significance of clostridial glucosylating toxins1–4. Virulence is dependent on the autoactivation of a toxin cysteine protease5–9, which is promoted