Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Bo H. Bentzen"'
1
Akademický článek
2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels
Autor: Rafel Simó-Vicens, Sofia H. Bomholtz, Ulrik S. Sørensen, Bo H. Bentzen
Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)
A variety of polycyclic pyridines have been proposed as inhibitors of the small conductance calcium-activated potassium (SK) channel. To this group belongs 2,6-bis(2-benzimidazolyl)pyridine (BBP), a commercially and readily available small organic co
Externí odkaz: https://doaj.org/article/d72356213dd44457a08fa507a592b688
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3
Akademický článek
Quantitative proteome comparison of human hearts with those of model organisms.
Autor: Nora Linscheid, Alberto Santos, Pi Camilla Poulsen, Robert W Mills, Kirstine Calloe, Ulrike Leurs, Johan Z Ye, Christian Stolte, Morten B Thomsen, Bo H Bentzen, Pia R Lundegaard, Morten S Olesen, Lars J Jensen, Jesper V Olsen, Alicia Lundby
Publikováno v: PLoS Biology, Vol 19, Iss 4, p e3001144 (2021)
Delineating human cardiac pathologies and their basic molecular mechanisms relies on research conducted in model organisms. Yet translating findings from preclinical models to humans present a significant challenge, in part due to differences in card
Externí odkaz: https://doaj.org/article/803278d7d2314c97a5198af5d5449f9c
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4
Pharmacological inhibition of SK-channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events
Autor: Benedikt Linz, Eva M. Hesselkilde, Mark A. Skarsfeldt, Julie N. Hertel, Stefan M. Sattler, Yannan Yan, Jacob Tfelt‐Hansen, Jonas G. Diness, Bo H. Bentzen, Dominik Linz, Thomas Jespersen
Publikováno v: Linz, B, Hesselkilde, E M, Skarsfeldt, M A, Hertel, J N, Sattler, S M, Yan, Y, Tfelt-Hansen, J, Diness, J G, Bentzen, B H, Linz, D & Jespersen, T 2023, ' Pharmacological inhibition of SK-channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events ', Journal of Cardiovascular Electrophysiology, vol. 34, no. 1, pp. 126-134 . https://doi.org/10.1111/jce.15769
Journal of Cardiovascular Electrophysiology, 34(1), 126-134. Wiley
BACKGROUND: Obstructive sleep apnea (OSA) creates a complex substrate for atrial fibrillation (AF), which is refractory to many clinically available pharmacological interventions. We investigated atrial antiarrhythmogenic properties and ventricular e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ba9b6efcb8475d708a12d2946d4001
https://pubmed.ncbi.nlm.nih.gov/36482155
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5
Polyunsaturated fatty acid-derived I
Autor: Mark A, Skarsfeldt, Sara I, Liin, Hans P, Larsson, Bo H, Bentzen
Publikováno v: Acta physiologica (Oxford, England). 229(4)
We aimed to assess the ability of natural and modified polyunsaturated fatty acids (PUFAs) to shorten QT interval in ex-vivo and in-vivo guinea pig hearts.The effect of one natural (docosahexaenoic acid [DHA]) and three modified (linoleoyl glycine [L
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d1313d0c5ad4eb873f772dd89f1f772b
https://pubmed.ncbi.nlm.nih.gov/32330372
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6
A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (K
Autor: Rafel, Simó-Vicens, Jeppe E, Kirchhoff, Bernardo, Dolce, Lea, Abildgaard, Tobias, Speerschneider, Ulrik S, Sørensen, Morten, Grunnet, Jonas G, Diness, Bo H, Bentzen
Publikováno v: British journal of pharmacology. 174(23)
Small conductance calcium-activated potassium (KUsing site-directed mutagenesis, binding determinants for AP14145 inhibition were explored. AP14145 selectivity and mechanism of action were investigated by patch-clamp recordings of heterologously expr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::584cefb779c8321257eeb3242096ff21
https://pubmed.ncbi.nlm.nih.gov/28925012
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7
pH-dependent inhibition of K₂P3.1 prolongs atrial refractoriness in whole hearts
Autor: Mark A, Skarsfeldt, Thomas A, Jepps, Sofia H, Bomholtz, Lea, Abildgaard, Ulrik S, Sørensen, Emilie, Gregers, Jesper H, Svendsen, Jonas G, Diness, Morten, Grunnet, Nicole, Schmitt, Søren-Peter, Olesen, Bo H, Bentzen
Publikováno v: Pflugers Archiv : European journal of physiology. 468(4)
In isolated human atrial cardiomyocytes, inhibition of K2P3.1 K(+) channels results in action potential (action potential duration (APD)) prolongation. It has therefore been postulated that K2P3.1 (KCNK3), together with K2P9.1 (KCNK9), could represen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::71cc43222892762d083f471f7bb209f7
https://pubmed.ncbi.nlm.nih.gov/26729267
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8
Biophysical characterization of inwardly rectifying potassium currents (I(K1) I(K,ACh), I(K,Ca)) using sinus rhythm or atrial fibrillation action potential waveforms
Autor: Chuyi, Tang, Lasse, Skibsbye, Lei, Yuan, Bo H, Bentzen, Thomas, Jespersen
Publikováno v: General physiology and biophysics. 34(4)
Although several physiological, pathophysiological and regulatory properties of classical inward rectifier K+ current I(K1), G-protein coupled inwardly-rectifying K+ current I(K,ACh) and the small-conductance Ca2+ activated K+ current I(K,Ca) have be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3608082b902b943ef99b4c6ed85d210b
https://pubmed.ncbi.nlm.nih.gov/26001288
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Plný text Recenzováno Digitální knihovna AV ČR
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