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Airway Elastin is increased in severe asthma and relates to proximal wall area : histological and computed tomography findings from the U-BIOPRED severe asthma study

Autor: Bo Billing, Peter J. Sterk, Ana R. Sousa, Dominick E. Shaw, Norbert Krug, Susan J. Wilson, Christopher E. Brightling, Simonetta Baldi, Helen M Pickett, Thomas Sandstrӧm, Kian Fan Chung, Peter H. Howarth, Barbro Dahlén, Jonathan Ward, Ratko Djukanovic

Publikováno v: Clinical and experimental allergy, 51(2), 296-304. Wiley-Blackwell

Background: Airway remodelling, which may include goblet cell hyperplasia / hypertrophy, changes in epithelial integrity, accumulation of extracellular matrix components, smooth muscle hypertrophy and thickening of the lamina reticularis, is a featur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8caa8bcb4efdd4f93fcea573df2f66
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179427

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Impact of tobacco smoking on cytokine signaling via interleukin-17A in the peripheral airways

Autor: Ingemar Qvarfordt, Pernilla Glader, Anders Lindén, Lena Palmberg, Barbro Dahlén, Kjell Larsson, Bettina Levänen, Bo Billing

Publikováno v: International Journal of Chronic Obstructive Pulmonary Disease

Bettina Levänen,1 Pernilla Glader,2 Barbro Dahlén,3,4 Bo Billing,4 Ingemar Qvarfordt,2 Lena Palmberg,1 Kjell Larsson,1 Anders Lindén1,2,4 1Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 2D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e24235be1e1412b206d03ed218be907
https://www.dovepress.com/impact-of-tobacco-smoking-on-cytokine-signaling-via-interleukin-17a-in-peer-reviewed-article-COPD

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Dendritic cell functional properties in a three-dimensional tissue model of human lung mucosa

Autor: Anh Thu Nguyen Hoang, Mark Coles, Barbro Dahlén, Julius Juarez, Puran Chen, Patty Sachamitr, Lidija Bosnjak, Bo Billing, Mattias Svensson

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 302:L226-L237

In lung tissue, dendritic cells (DC) are found in close association with the epithelial cell layer, and there is evidence of DC regulation by the epithelium; that epithelial dysfunction leads to overzealous immune cell activation. However, dissecting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e636eea6dde79abfa96e78ff1d20e02
https://doi.org/10.1152/ajplung.00059.2011

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Toll-like receptor expression in smokers with and without COPD

Autor: Maria Skedinger, Bo Billing, Ida von Schéele, Ann-Sofie Lantz, Kjell Larsson, Lena Palmberg, Barbro Dahlén

Publikováno v: Respiratory Medicine. 105:1222-1230

Summary Introduction Chronic obstructive pulmonary disease (COPD) is characterized by non-reversible airflow limitation and systemic engagement. Bacterial colonization in the lungs is common in COPD-patients and may be associated with frequent acute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dedc76609f7a9431fa32b2cbe030ba2
https://doi.org/10.1016/j.rmed.2011.02.012

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Compartment differences of inflammatory activity in chronic obstructive pulmonary disease

Autor: Barbro Dahlén, Lena Palmberg, Jie Ji, Ida von Schéele, Kjell Larsson, Bo Billing, Ann-Sofie Lantz, Jan Bergström

Publikováno v: Respiratory Research

Background: Chronic obstructive pulmonary disease (COPD) is associated with local and systemic inflammation. The knowledge of interaction and co-variation of the inflammatory responses in different compartments is meagre. Method: Healthy controls (n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55600d566614dfe14d8b1dfa3f4dfe32
http://europepmc.org/articles/PMC4243731

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Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma

Autor: Maciej Kupczyk, David Balgoma, Elisabeth Henriksson, Sven-Erik Dahlén, Bo Billing, Craig E. Wheelock, Garret A. FitzGerald, Agneta Lindeberg, Barbro Dahlén, Kameran Daham, Anna James

Publikováno v: The Journal of allergy and clinical immunology. 134(2)

Background Prostaglandins that constrict and relax airways are synthesized in reactions catalyzed by either COX-1 or COX-2. It is not known whether selective inhibition of COX-2 makes asthmatic responses better or worse. Objective To determine the ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624a2d46fec2f312d181c1111f80ff5f
https://pubmed.ncbi.nlm.nih.gov/24461582

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Allergen challenge-induced entry of α-macroglobulin and tryptase into human nasal and bronchial airways

Autor: Lennart Greiff, Bo Billing, U. Alkner, Reidar Grönneberg, Hans Gilljam, Carl G. A. Persson, Morgan Andersson, Olof Andersson, Christer Svensson

Publikováno v: Journal of Allergy and Clinical Immunology. 96:239-246

Background: Microvascular-epithelial exudation of bulk plasma may characterize inflammatory airway diseases. This study compares the acute allergen challenge–induced mast cell and exudative responses in nasal and bronchial airways. The focus is on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c41f1f327ef897c4a7b917dff36474ca
https://doi.org/10.1016/s0091-6749(95)70013-7

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Effects of budesonide on toll-like receptor expression in alveolar macrophages from smokers with and without COPD

Autor: Jie Ji, Bo Billing, Lena Palmberg, Ida von Schéele, Ann-Sofie Lantz, Barbro Dahlén, Kjell Larsson

Publikováno v: International Journal of Chronic Obstructive Pulmonary Disease

Jie Ji,1 Ida von Schéele,1 Bo Billing,2 Barbro Dahlén,2 Ann-Sofie Lantz,2 Kjell Larsson,1 Lena Palmberg1 1Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; 2Department of Medicine, Karolinska I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe3d356c7dce6b39f55ed322087b85a
https://doi.org/10.2147/copd.s102668

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