Gut microbiota induce local and systemic CD4 T cell responses in healthy individuals that are altered in inflammatory bowel diseases

Autor: Fiona Powrie, Holm H. Uhlig, Satish Keshav, K Suijker, Mjt Stubbington, Bmj Owens, Andreas Bergthaler, Andrew J. McMichael, Sarah A. Teichmann, A. Datsi, Ahmed N. Hegazy, Nathan R. West, Emily Wendt, Sylvia H. Duncan, Camille Danne, Suzanne Campion, S This

Publikováno v: 72. Jahrestagung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten mit Sektion Endoskopie – 11. Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie gemeinsam mit den Arbeitsgemeinschaften der DGAV.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ef4e1b38fa087b96dea40987ce3691a
https://doi.org/10.1055/s-0037-1604874

Siltuximab downregulates interleukin-8 and pentraxin 3 to improve ventilatory status and survival in severe COVID-19.

Autor: Gritti G; Hematology Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy. g.gritti@asst-pg23.it., Raimondi F; Pneumology Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy.; Postgraduate School of Respiratory Medicine, University of Milan, Milan, Italy., Bottazzi B; Humanitas Clinical and Research Center - IRCCS, Milan, Italy., Ripamonti D; Infectious Diseases Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy., Riva I; Intensive Care Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy., Landi F; Hematology Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy.; Postgraduate School of Hematology, University of Milan, Milan, Italy., Alborghetti L; Infectious Diseases Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy., Frigeni M; Hematology Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy., Damiani M; Intensive Care Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy.; Postgraduate School of Anesthesiology and Intensive Care, University of Milan, Milan, Italy., Micò C; Hematology Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy., Fagiuoli S; Gastroenterology Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy., Lorini FL; Intensive Care Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy., Gandini L; Intensive Care Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy.; Postgraduate School of Anesthesiology and Intensive Care, University of Milan, Milan, Italy., Novelli L; Pneumology Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy., Morgan JP; EUSA Pharma, Hemel Hempstead, UK., Owens BMJ; EUSA Pharma, Hemel Hempstead, UK., Kanhai KJK; EUSA Pharma, Hemel Hempstead, UK., Reljanovic GT; ErgoMed PLC, Guildford, UK., Rizzi M; Infectious Diseases Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy., Di Marco F; Pneumology Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy.; Department of Health Sciences, University of Milan, Milan, Italy., Mantovani A; Postgraduate School of Respiratory Medicine, University of Milan, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; The William Harvey Research Institute, Queen Mary University of London, London, UK., Rambaldi A; Hematology Unit, Azienda Socio Sanitario Territoriale Papa Giovanni XXIII, Bergamo, Italy.; Department of Oncology-Hematology, University of Milan, Milan, Italy.

Publikováno v: Leukemia [Leukemia] 2021 Sep; Vol. 35 (9), pp. 2710-2714. Date of Electronic Publication: 2021 May 24.

Antiviral activity of bone morphogenetic proteins and activins.

Autor: Eddowes LA; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Al-Hourani K; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Ramamurthy N; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK., Frankish J; Research Group 'Dynamics of Early Viral Infection and the Innate Antiviral Response', Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany., Baddock HT; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Sandor C; Dementia Research Institute, Cardiff University, Cardiff, UK., Ryan JD; Centre for Liver Disease, Mater Misericordiae University Hospital, Dublin, Ireland.; Translational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford, UK., Fusco DN; Liver Center, Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Arezes J; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Giannoulatou E; Computational Biology Research Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Boninsegna S; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK.; Department of Surgical Gastroenterological Science, University of Padua, Padova, Italy., Chevaliez S; Liver Center, Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Owens BMJ; Translational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford, UK., Sun CC; Program in Anemia Signaling Research, Nephrology Division, Program in Membrane Biology, and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Fabris P; Department of Infectious Diseases and Tropical Medicine, San Bortolo Hospital, Vicenza, Italy., Giordani MT; Department of Infectious Diseases and Tropical Medicine, San Bortolo Hospital, Vicenza, Italy., Martines D; Department of Surgical Gastroenterological Science, University of Padua, Padova, Italy., Vukicevic S; Center for Translational and Clinical Research, School of Medicine, University of Zagreb, Zagreb, Croatia., Crowe J; Centre for Liver Disease, Mater Misericordiae University Hospital, Dublin, Ireland., Lin HY; Program in Anemia Signaling Research, Nephrology Division, Program in Membrane Biology, and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Rehwinkel J; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., McHugh PJ; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Binder M; Research Group 'Dynamics of Early Viral Infection and the Innate Antiviral Response', Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany., Babitt JL; Program in Anemia Signaling Research, Nephrology Division, Program in Membrane Biology, and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Chung RT; Liver Center, Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lawless MW; Experimental Medicine, UCD School of Medicine and Medical Science, Mater Misericordiae University Hospital, Dublin, Ireland., Armitage AE; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Webber C; Dementia Research Institute, Cardiff University, Cardiff, UK.; Department of Physiology, Anatomy & Genetics, Oxford University, Oxford, UK., Klenerman P; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford, UK.; NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK., Drakesmith H; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK. alexander.drakesmith@imm.ox.ac.uk.; Haematology Theme Oxford Biomedical Research Centre, Oxford, UK. alexander.drakesmith@imm.ox.ac.uk.

Publikováno v: Nature microbiology [Nat Microbiol] 2019 Feb; Vol. 4 (2), pp. 339-351. Date of Electronic Publication: 2018 Dec 03.

Circulating and Tissue-Resident CD4 ⁺ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.

Autor: Hegazy AN; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, United Kingdom; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom., West NR; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, United Kingdom; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom., Stubbington MJT; European Molecular Biology Laboratory-European Bioinformatics Institute, Hinxton, United Kingdom; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom., Wendt E; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, United Kingdom., Suijker KIM; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom., Datsi A; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, United Kingdom., This S; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, United Kingdom., Danne C; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom., Campion S; Nuffield Department of Medicine Research Building, University of Oxford, Oxford, United Kingdom., Duncan SH; Microbial Ecology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom., Owens BMJ; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, United Kingdom., Uhlig HH; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, United Kingdom; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., McMichael A; Nuffield Department of Medicine Research Building, University of Oxford, Oxford, United Kingdom., Bergthaler A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Teichmann SA; European Molecular Biology Laboratory-European Bioinformatics Institute, Hinxton, United Kingdom; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom., Keshav S; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, United Kingdom., Powrie F; Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, United Kingdom; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom. Electronic address: Fiona.Powrie@kennedy.ox.ac.uk.

Publikováno v: Gastroenterology [Gastroenterology] 2017 Nov; Vol. 153 (5), pp. 1320-1337.e16. Date of Electronic Publication: 2017 Aug 04.

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

Autor: West NR; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hegazy AN; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Owens BMJ; Somerville College, University of Oxford, Oxford, UK., Bullers SJ; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Linggi B; Janssen Research and Development, Raritan, New Jersey, USA., Buonocore S; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Coccia M; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Görtz D; Institute of Biochemistry and Molecular Biology, RWTH Aachen University, Aachen, Germany., This S; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Stockenhuber K; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Pott J; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Friedrich M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Ryzhakov G; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Baribaud F; Janssen Research and Development, Raritan, New Jersey, USA., Brodmerkel C; Janssen Research and Development, Raritan, New Jersey, USA., Cieluch C; Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, Germany., Rahman N; OPPF-UK, The Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell, Oxford, UK., Müller-Newen G; Institute of Biochemistry and Molecular Biology, RWTH Aachen University, Aachen, Germany., Owens RJ; OPPF-UK, The Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Kühl AA; Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, Germany., Maloy KJ; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK., Plevy SE; Janssen Research and Development, Raritan, New Jersey, USA., Keshav S; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Travis SPL; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Powrie F; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Publikováno v: Nature medicine [Nat Med] 2017 May; Vol. 23 (5), pp. 579-589. Date of Electronic Publication: 2017 Apr 03.