Zobrazeno 1 - 10
of 2 501
pro vyhledávání: '"Bmal1"'
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 3903-3919 (2024)
Ting Liu,1,2 Luxu Wang,1– 3 Tuo Shi,4 Hongrui Liu,1,2 Bo Liu,5 Jie Guo,1,2 Minqi Li1,2,5 1Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue R
Externí odkaz:
https://doaj.org/article/3565578a738f4cabbc0d1b1b17ffe692
Autor:
Xu Cao, Jinhai Tian, Man Yee Cheung, Liangying Zhang, Zimei Liu, Zongying Jiang, Shaoting Zhang, Kun Xiao, Sien Zhao, Ming Wang, Feng Ding, Shujing Li, Lijun Ma, Hui Zhao, Jianmin Sun
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Background Zinc finger SWIM-type containing 4 (ZSWIM4) is a zinc finger protein with its function largely uncharacterized. In this study, we aimed to investigate the role of ZSWIM4 in gastrointestinal stromal tumors (GISTs). Results We found
Externí odkaz:
https://doaj.org/article/b63a695bbaaf4f9e96096d1eaf3f4d65
Publikováno v:
BMC Ophthalmology, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Sleep deprivation (SD) is a common public health problem that contributes to various physiological disorders and increases the risk of ocular diseases. However, whether sleep loss can damage corneal endothelial function remains un
Externí odkaz:
https://doaj.org/article/52c4281de7a7421aaff3860307476796
Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor
Autor:
Weifen Li, Shengnan Mou, Tahir Ali, Tianxiang Li, Yan Liu, Shupeng Li, Xiaoming Yu, Zhi-Jian Yu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundBMAL1, a key regulator of circadian rhythms, plays a multifaceted role in brain function. However, the complex interplay between BMAL1, memory, neuroinflammation, and neurotransmitter regulation remains poorly understood. To investigate the
Externí odkaz:
https://doaj.org/article/f0ab59b4e7394795a3a593bcaa25a065
Publikováno v:
Brain Research Bulletin, Vol 215, Iss , Pp 111033- (2024)
Brain Muscle ARNT-Like Protein 1 (BMAL1) suppresses oxidative stress in brain injury during surgery. Epigallocatechin-3-gallate (EGCG), a monomer in green tea, has been identified as an antioxidant and a potential agonist for BMAL1. In this work, the
Externí odkaz:
https://doaj.org/article/7d9ca1885a4f4c08a76fdaaa4536bf4c
Autor:
Paula Berbegal-Sáez, Ines Gallego-Landin, Javier Macía, Laia Alegre-Zurano, Adriana Castro-Zavala, Patrick-Simon Welz, Salvador A. Benitah, Olga Valverde
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
Maintaining proper circadian rhythms is essential for coordinating biological functions in mammals. This study investigates the effects of daily arrhythmicity using Bmal1-knockout (KO) mice as a model, aiming to understand behavioural and motivationa
Externí odkaz:
https://doaj.org/article/3137121a7c5c4c9195553cb0a32dc0f9
Autor:
Colleen M. Bartman, Lisa Nesbitt, Kenge K. Lee, Latifa Khalfaoui, Yun‐Hua Fang, Christina M. Pabelick, Y. S. Prakash
Publikováno v:
Physiological Reports, Vol 12, Iss 13, Pp n/a-n/a (2024)
Abstract Supplemental O2 (hyperoxia) is a critical intervention for premature infants (
Externí odkaz:
https://doaj.org/article/69b90bc72683470b87e4976f4d1a4f66
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundCircadian rhythm disruption (CRD) is thought to increase the risk of inflammatory bowel disease. The deletion of Bmal1, a core transcription factor, leads to a complete loss of the circadian rhythm and exacerbates the severity of dextran so
Externí odkaz:
https://doaj.org/article/3a4f4876b7a2487a8c00a2be81983782
Autor:
Glenn R. Yamakawa, Meshwa Patel, Runxuan Lin, Terence J. O'Brien, Richelle Mychasiuk, Pablo M. Casillas‐Espinosa
Publikováno v:
Epilepsia Open, Vol 8, Iss 4, Pp 1523-1531 (2023)
Abstract Objectives Growing evidence demonstrates a relationship between epilepsy and the circadian system. However, relatively little is known about circadian function in disease states, such as epilepsy. This study aimed to characterize brain and p
Externí odkaz:
https://doaj.org/article/b09075573573429ab4e896b4a16c581d
Autor:
Yoon Kyoung Kim, Han Kyoung Choe
Publikováno v:
Animal Cells and Systems, Vol 27, Iss 1, Pp 425-435 (2023)
ABSTRACTPerception and production of second-level temporal intervals are critical in several behavioral and cognitive processes, including adaptive anticipation, motor control, and social communication. These processes are impaired in several neurolo
Externí odkaz:
https://doaj.org/article/6a0dd23f2e5944f0a0735bf9dbd1cee3