Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74

Autor: Djudjaj S, Lue H, Rong S, Papasotiriou M, Bm, Klinkhammer, Zok S, Klaener O, Gs, Braun, Mt, Lindenmeyer, Cd, Cohen, Bucala R, Ap, Tittel, Kurts C, Mj, Moeller, Floege J, Ostendorf T, Bernhagen J, Peter Boor

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::362111e4c6b923000dbbdef1bf2f7c72
http://europepmc.org/abstract/med/26453615

ADAMTS12 promotes fibrosis by restructuring extracellular matrix to enable activation of injury-responsive fibroblasts.

Autor: Hoeft K; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany., Koch L; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany., Ziegler S; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany., Zhang L; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany., Luetke S; Department of Pediatrics and Adolescent Medicine.; Center for Biochemistry, Medical Faculty, and.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany., Tanzer MC; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.; Max-Planck Institute of Biochemistry, Martinsried, Germany., Mohanta D; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany., Schumacher D; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany.; Department of Anesthesiology, RWTH Aachen University, Aachen, Germany., Schreibing F; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany.; Sequantrix GmbH, Aachen, Germany., Long Q; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany., Kim H; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany., Klinkhammer BM; Institute of Pathology, RWTH Aachen University, Aachen, Germany., Schikarski C; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany., Maryam S; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany., Baens M; CISTIM Leuven vzw, Leuven, Belgium., Hermann J; Institute for Molecular Cardiovascular Research, RWTH Aachen University, Medical Faculty, Aachen, Germany., Krieg S; Institute of Biochemistry and Molecular Biology, and., Peisker F; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany., De Laporte L; Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, Germany.; Institute of Applied Medical Engineering, Department of Advanced Materials for Medicine, University Hospital RWTH Aachen, Aachen, Germany.; DWI-Leibniz Institute of Interactive Materials, Aachen, Germany., Schaefer GJ; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany., Menzel S; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany., Jankowski J; Institute for Molecular Cardiovascular Research, RWTH Aachen University, Medical Faculty, Aachen, Germany., Humphreys BD; Division of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA., Wahida A; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany., Schneider RK; Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.; Department of Cell Biology, Institute for Biomedical Technologies, RWTH Aachen University, Aachen, Germany., Versele M; CISTIM Leuven vzw, Leuven, Belgium., Boor P; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany.; Institute of Pathology, RWTH Aachen University, Aachen, Germany., Mann M; Max-Planck Institute of Biochemistry, Martinsried, Germany., Sengle G; Department of Pediatrics and Adolescent Medicine.; Center for Biochemistry, Medical Faculty, and.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany., Hayat S; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany., Kramann R; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), RWTH Aachen University, Medical Faculty, Aachen, Germany.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Sep 17; Vol. 134 (18). Date of Electronic Publication: 2024 Sep 17.

PDGF-D Is Dispensable for the Development and Progression of Murine Alport Syndrome.

Autor: Firat EAM; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany., Buhl EM; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany; Electron Microscopy Facility, RWTH Aachen University Hospital, Aachen, Germany., Bouteldja N; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany., Smeets B; Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands., Eriksson U; Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden., Boor P; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany; Electron Microscopy Facility, RWTH Aachen University Hospital, Aachen, Germany; Department of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany. Electronic address: pboor@ukaachen.de., Klinkhammer BM; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany.

Publikováno v: The American journal of pathology [Am J Pathol] 2024 May; Vol. 194 (5), pp. 641-655. Date of Electronic Publication: 2024 Feb 01.

2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function.

Autor: Moellmann J; Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Aachen, Germany., Krueger K; Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Aachen, Germany., Wong DWL; Institute of Pathology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany., Klinkhammer BM; Institute of Pathology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany., Buhl EM; Institute of Pathology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany; Department of Nephrology, RWTH Aachen University, Aachen, Germany; Electron Microscopy Facility, RWTH Aachen University, Aachen, Germany., Dehairs J; Laboratory of Lipid Metabolism and Cancer, Department of Oncology, LKI - Leuven Cancer Institute, KU Leuven - University of Leuven, Leuven, Belgium., Swinnen JV; Laboratory of Lipid Metabolism and Cancer, Department of Oncology, LKI - Leuven Cancer Institute, KU Leuven - University of Leuven, Leuven, Belgium., Noels H; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany., Jankowski J; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany., Lebherz C; Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Aachen, Germany., Boor P; Institute of Pathology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany; Department of Nephrology, RWTH Aachen University, Aachen, Germany., Marx N; Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Aachen, Germany., Lehrke M; Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Aachen, Germany. Electronic address: mlehrke@ukaachen.de.

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Jan; Vol. 1870 (1), pp. 166825. Date of Electronic Publication: 2023 Aug 01.

Semiautomated pipeline for quantitative analysis of heart histopathology.

Autor: Droste P; LaBooratory of Nephropathology, Institute of Pathology, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Division of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany., Wong DWL; LaBooratory of Nephropathology, Institute of Pathology, Medical Faculty, RWTH Aachen University, Aachen, Germany., Hohl M; Department of Internal Medicine III, University Hospital, Saarland University, Homburg, Germany., von Stillfried S; LaBooratory of Nephropathology, Institute of Pathology, Medical Faculty, RWTH Aachen University, Aachen, Germany., Klinkhammer BM; LaBooratory of Nephropathology, Institute of Pathology, Medical Faculty, RWTH Aachen University, Aachen, Germany., Boor P; LaBooratory of Nephropathology, Institute of Pathology, Medical Faculty, RWTH Aachen University, Aachen, Germany. pboor@ukaachen.de.; Division of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany. pboor@ukaachen.de.

Publikováno v: Journal of translational medicine [J Transl Med] 2023 Sep 26; Vol. 21 (1), pp. 666. Date of Electronic Publication: 2023 Sep 26.