Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Blythe D. Sather"'
Autor:
Brenda J. Seymour, Swati Singh, Hannah M. Certo, Karen Sommer, Blythe D. Sather, Socheath Khim, Courtnee Clough, Malika Hale, Joseph Pangallo, Byoung Y. Ryu, Iram F. Khan, Jennifer E. Adair, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 635-651 (2021)
X-linked agammaglobulinemia (XLA) is an immune disorder caused by mutations in Bruton’s tyrosine kinase (BTK). BTK is expressed in B and myeloid cells, and its deficiency results in a lack of mature B cells and protective antibodies. We previously
Externí odkaz:
https://doaj.org/article/4469c8d686fc425a84ca48e687ffdce5
Autor:
Guillermo S Romano Ibarra, Biswajit Paul, Blythe D Sather, Patrick M Younan, Karen Sommer, John P Kowalski, Malika Hale, Barry Stoddard, Jordan Jarjour, Alexander Astrakhan, Hans-Peter Kiem, David J Rawlings
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
A naturally occurring 32-base pair deletion of the HIV-1 co-receptor CCR5 has demonstrated protection against HIV infection of human CD4+ T cells. Recent genetic engineering approaches using engineered nucleases to disrupt the gene and mimic this mut
Externí odkaz:
https://doaj.org/article/9a753dd3c9794ca9b239d6c43c9c7b98
Autor:
Alex Baturevych, Yue Jiang, Michael Ports, Patrick Carlson, Heidi K. Jessup, David G. Kugler, Neha Soni, Ronald J. Hause, Catherine Sierra, Christopher R. Clouser, Collin Hauskins, Jon C. Jones, Timothy G. Johnstone, Lindsey Wimberly, Melissa Works, Ruth Salmon, Wendy Curtis, Blythe D. Sather
Publikováno v:
Molecular cancer therapeutics. 18(12)
Anti–B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cells have shown promising clinical responses in patients with relapsed/refractory multiple myeloma. Lenalidomide, an immunomodulatory drug, potentiates T cell functionality, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9caecea46418a9d2776b32c8698555d3
https://pubmed.ncbi.nlm.nih.gov/31395689
https://pubmed.ncbi.nlm.nih.gov/31395689
Autor:
Stanley R. Riddell, Edward N. Libby, Blythe D. Sather, Pamela S. Becker, Andrew J. Cowan, Michelle L Blake, Margot J. Pont, Anne M Nagengast, Ted Gooley, Brian G. Till, David G. Maloney, Qian Vicky Wu, Melissa Works, Sherilyn A. Tuazon, Cameron J. Turtle, Damian J. Green, Brent L. Wood, David G. Coffey
Publikováno v:
Blood. 134:204-204
Background: Although the median survival for patients with multiple myeloma has improved dramatically, almost all patients will eventually relapse and become resistant to standard therapies. Chimeric antigen receptor T cells (CAR T cells) targeting B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4789c22ea7fc219c31c349f722292b9c
https://doi.org/10.1182/blood-2019-129405
https://doi.org/10.1182/blood-2019-129405
Autor:
Sushma S. Thomas, Ted Gooley, Michelle L Blake, Damian J. Green, Margot J. Pont, Anne M Nagengast, David G. Maloney, Xaoling Song, Stanley R. Riddell, Gabriel O. Cole, Blythe D. Sather, Andrew J. Cowan, Brent L. Wood, Melissa Works
Publikováno v:
Blood. 134:1856-1856
Introduction: The adoptive transfer of B-Cell Maturation Antigen (BCMA) chimeric antigen receptor (CAR) T cells is demonstrating early promise in multiple myeloma [MM], however durable responses remain elusive and most studies report >50% of patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f98f10f13a20f15be989ba05c8fcf8
https://doi.org/10.1182/blood-2019-129582
https://doi.org/10.1182/blood-2019-129582
Autor:
Ruth Salmon, Eric M. Chadwick, Bailey Donahue, Melissa Chin, G. Grant Welstead, Clay Patton, Blythe D. Sather, Stephen Michael Burleigh, Dean Y. Toy, Brian J. Belmont, David Jeffrey Huss, Alexandra Croft, Stephen J. Goldfless, Cameron S. Brandt
Publikováno v:
Cancer Immunology Research. 7:A027-A027
Background: Adoptive T-cell therapy with engineered T-cell receptors (eTCR) has demonstrated promising, yet modest clinical benefit to date. Key obstacles for this technology are 1) competition with the endogenous TCR for CD3 components that are requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3c119b6b86fcccb5af7ff0ffe56dc0b
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a027
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a027
Autor:
Blythe D. Sather, Karen Sommer, John P. Kowalski, Hans-Peter Kiem, Alexander Astrakhan, Malika Hale, Biswajit Paul, Patrick Younan, Guillermo S. Romano Ibarra, Barry L. Stoddard, Jordan Jarjour, David J. Rawlings
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
A naturally occurring 32-base pair deletion of the HIV-1 co-receptor CCR5 has demonstrated protection against HIV infection of human CD4+ T cells. Recent genetic engineering approaches using engineered nucleases to disrupt the gene and mimic this mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d422e1273223a98846b22c23288cac26
http://www.sciencedirect.com/science/article/pii/S2162253117300720
http://www.sciencedirect.com/science/article/pii/S2162253117300720
Autor:
Terence J. Purdon, Kimberly Harrington, Trevor Do, Jon C. Jones, Eric L. Smith, Majid Ghoddusi, Hong Liu, Carlos Fernández de Larrea, Sarah C. Garrett, Steven C. Almo, Xiuyan Wang, Minh Thu Pham, Mette Staehr, Yiyang Xu, Elizabeth Peguero, Blythe D. Sather, Jessica M. Brown, Reed Masakayan, Cheng Liu, Renier J. Brentjens, Pei Wang, Thomas Long, Isabelle Riviere
Publikováno v:
Blood. 132:589-589
Early clinical results using BCMA targeted CAR T cell therapies for advanced multiple myeloma (MM) have shown promise. However, BCMA expression can be variable, and BCMA downregulation has been correlated with relapse (Brudno J. JCO. 2018; Cohen A. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75ef4bbbb6f01bd6212fbebe5d266ef2
https://doi.org/10.1182/blood-2018-99-110471
https://doi.org/10.1182/blood-2018-99-110471
Publikováno v:
The Journal of Immunology. 185:4760-4768
Type 1 diabetes (T1D) results from the immune-mediated destruction of the insulin-producing β-islet cells in the pancreas. The genetic and environmental mechanisms promoting the development of this disease remain poorly understood. We have explored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::841ade204e708825c24697253fe2f163
https://doi.org/10.4049/jimmunol.1000820
https://doi.org/10.4049/jimmunol.1000820
Autor:
Jason D. Fontenot, Blythe D. Sather, Piper R. Treuting, Nikole Perdue, Alexander Y. Rudensky, Mike Miazgowicz, Daniel J. Campbell
Publikováno v:
The Journal of Experimental Medicine
CD4+Foxp3+ regulatory T cells (T reg) are essential for maintaining self-tolerance, but their functional mechanisms and sites of action in vivo are poorly defined. We examined the homing receptor expression and tissue distribution of T reg cells in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d95ea0efddbbdad5f01d9d7c9ce7b11
https://doi.org/10.1084/jem.20070081
https://doi.org/10.1084/jem.20070081