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Fungi are a valuable source of enzymatic diversity and therapeutic natural products including antibiotics. Here we engineer the baker’s yeast Saccharomyces cerevisiae to produce and secrete the antibiotic penicillin, a beta-lactam nonribosomal pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::bd25938342f82e02ad0fda35b435efaa
http://hdl.handle.net/10044/1/48888
http://hdl.handle.net/10044/1/48888
Autor:
Schindler D; Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UK; Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany; Center for Synthetic Microbiology (SYNMIKRO), Philipps-University Marburg, 35032 Marburg, Germany., Walker RSK; School of Engineering, Institute for Bioengineering, The University of Edinburgh, Edinburgh EH9 3BF, Scotland; School of Natural Sciences and ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, NSW 2109, Australia., Jiang S; CAS Key Laboratory of Quantitative Engineering Biology, Guangdong Provincial Key Laboratory of Synthetic Genomics and Shenzhen Key Laboratory of Synthetic Genomics, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Brooks AN; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany., Wang Y; BGI-Shenzhen, Beishan Industrial Zone, Shenzhen 518083, China; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518120, China., Müller CA; Earlham Institute, Norwich Research Park, Norwich NR4 7UZ, UK; School of Biological Sciences, University of East Anglia, Norwich NR4 7TU, UK., Cockram C; Institut Pasteur, CNRS UMR 3525, Université Paris Cité, Unité Régulation Spatiale des Génomes, 75015 Paris, France., Luo Y; Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UK., García A; Instituto de Biología Funcional y Genómica (IBFG), CSIC, Universidad de Salamanca, Salamanca, Spain., Schraivogel D; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany., Mozziconacci J; Institut Pasteur, CNRS UMR 3525, Université Paris Cité, Unité Régulation Spatiale des Génomes, 75015 Paris, France., Pena N; Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA., Assari M; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA., Sánchez Olmos MDC; Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany., Zhao Y; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA., Ballerini A; Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UK., Blount BA; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK; Department of Bioengineering, Imperial College London, London, UK., Cai J; Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA., Ogunlana L; School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, Scotland., Liu W; School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, Scotland., Jönsson K; School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, Scotland., Abramczyk D; School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, Scotland., Garcia-Ruiz E; Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UK., Turowski TW; Institute of Biochemistry and Biophysics PAS, Pawińskiego 5a, 02-106 Warszawa, Poland., Swidah R; Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UK., Ellis T; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK; Department of Bioengineering, Imperial College London, London, UK., Pan T; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA., Antequera F; Instituto de Biología Funcional y Genómica (IBFG), CSIC, Universidad de Salamanca, Salamanca, Spain., Shen Y; Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UK; BGI-Shenzhen, Beishan Industrial Zone, Shenzhen 518083, China; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen 518120, China., Nieduszynski CA; Earlham Institute, Norwich Research Park, Norwich NR4 7UZ, UK; School of Biological Sciences, University of East Anglia, Norwich NR4 7TU, UK., Koszul R; Institut Pasteur, CNRS UMR 3525, Université Paris Cité, Unité Régulation Spatiale des Génomes, 75015 Paris, France., Dai J; CAS Key Laboratory of Quantitative Engineering Biology, Guangdong Provincial Key Laboratory of Synthetic Genomics and Shenzhen Key Laboratory of Synthetic Genomics, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Steinmetz LM; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany; Department of Genetics and Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA., Boeke JD; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA; Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn, NY 11201, USA., Cai Y; Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UK. Electronic address: yizhi.cai@manchester.ac.uk.
Publikováno v:
Cell [Cell] 2023 Nov 22; Vol. 186 (24), pp. 5237-5253.e22. Date of Electronic Publication: 2023 Nov 08.
Autor:
Blount BA; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.; Department of Bioengineering, Imperial College London, London, UK.; School of Life Sciences, University of Nottingham, Nottingham, UK., Lu X; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.; Department of Bioengineering, Imperial College London, London, UK., Driessen MRM; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.; Department of Bioengineering, Imperial College London, London, UK., Jovicevic D; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.; Department of Bioengineering, Imperial College London, London, UK., Sanchez MI; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.; Department of Bioengineering, Imperial College London, London, UK., Ciurkot K; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.; Department of Bioengineering, Imperial College London, London, UK., Zhao Y; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA., Lauer S; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA., McKiernan RM; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.; Department of Bioengineering, Imperial College London, London, UK.; Department of Life Sciences, Imperial College London, London, UK., Gowers GF; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.; Department of Bioengineering, Imperial College London, London, UK., Sweeney F; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.; Department of Life Sciences, Imperial College London, London, UK., Fanfani V; School of Biological Sciences, The University of Edinburgh, Edinburgh, UK., Lobzaev E; School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.; School of Informatics, The University of Edinburgh, Edinburgh, UK., Palacios-Flores K; Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Querétaro, México., Walker RSK; School of Engineering, Institute for Bioengineering, The University of Edinburgh, Edinburgh, UK., Hesketh A; Department of Biochemistry, University of Cambridge, Cambridge, UK., Cai J; Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA., Oliver SG; Department of Biochemistry, University of Cambridge, Cambridge, UK., Cai Y; School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.; Manchester Institute of Biotechnology, University of Manchester, Manchester, UK., Stracquadanio G; School of Biological Sciences, The University of Edinburgh, Edinburgh, UK., Mitchell LA; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA., Bader JS; Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA., Boeke JD; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.; Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn, NY, USA., Ellis T; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.; Department of Bioengineering, Imperial College London, London, UK.
Publikováno v:
Cell genomics [Cell Genom] 2023 Nov 09; Vol. 3 (11), pp. 100418. Date of Electronic Publication: 2023 Nov 09 (Print Publication: 2023).
Autor:
Xu X; ARC Centre of Excellence in Synthetic Biology and School of Natural Sciences, Macquarie University, Sydney, NSW, 2109, Australia. xin.xu@mq.edu.au., Meier F; ARC Centre of Excellence in Synthetic Biology and School of Natural Sciences, Macquarie University, Sydney, NSW, 2109, Australia., Blount BA; School of Life Sciences, University of Nottingham, Nottingham, NG7 2RD, UK., Pretorius IS; ARC Centre of Excellence in Synthetic Biology and School of Natural Sciences, Macquarie University, Sydney, NSW, 2109, Australia., Ellis T; Imperial College Centre for Synthetic Biology, Imperial College London, London, SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.; Wellcome Trust Sanger Institute, Cambridgeshire, CB10 1SA, UK., Paulsen IT; ARC Centre of Excellence in Synthetic Biology and School of Natural Sciences, Macquarie University, Sydney, NSW, 2109, Australia., Williams TC; ARC Centre of Excellence in Synthetic Biology and School of Natural Sciences, Macquarie University, Sydney, NSW, 2109, Australia. tom.williams@mq.edu.au.
Publikováno v:
Nature communications [Nat Commun] 2023 Apr 08; Vol. 14 (1), pp. 1984. Date of Electronic Publication: 2023 Apr 08.
Publikováno v:
Nature [Nature] 2019 May; Vol. 569 (7757), pp. 492-494.
Autor:
Blount BA; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.; Department of Bioengineering, Imperial College London, London, UK., Ellis T; Imperial College Centre for Synthetic Biology, Imperial College London, London, UK.; Department of Bioengineering, Imperial College London, London, UK.
Publikováno v:
Synthetic biology (Oxford, England) [Synth Biol (Oxf)] 2018 Nov 27; Vol. 3 (1), pp. ysy020. Date of Electronic Publication: 2018 Nov 27 (Print Publication: 2018).
Autor:
Blount BA; Imperial College Centre for Synthetic Biology, Imperial College London, London, SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK., Gowers GF; Imperial College Centre for Synthetic Biology, Imperial College London, London, SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK., Ho JCH; Imperial College Centre for Synthetic Biology, Imperial College London, London, SW7 2AZ, UK.; Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK., Ledesma-Amaro R; Imperial College Centre for Synthetic Biology, Imperial College London, London, SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK., Jovicevic D; Imperial College Centre for Synthetic Biology, Imperial College London, London, SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK., McKiernan RM; Imperial College Centre for Synthetic Biology, Imperial College London, London, SW7 2AZ, UK.; Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK., Xie ZX; Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, 300072, Tianjin, PR China.; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, 300072, Tianjin, PR China., Li BZ; Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, 300072, Tianjin, PR China.; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, 300072, Tianjin, PR China., Yuan YJ; Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, 300072, Tianjin, PR China.; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, 300072, Tianjin, PR China., Ellis T; Imperial College Centre for Synthetic Biology, Imperial College London, London, SW7 2AZ, UK. t.ellis@imperial.ac.uk.; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK. t.ellis@imperial.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2018 May 22; Vol. 9 (1), pp. 1932. Date of Electronic Publication: 2018 May 22.
Autor:
Awan AR; Centre for Synthetic Biology and Innovation, Imperial College London, London SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK., Blount BA; Centre for Synthetic Biology and Innovation, Imperial College London, London SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK., Bell DJ; Centre for Synthetic Biology and Innovation, Imperial College London, London SW7 2AZ, UK.; SynbiCITE Innovation and Knowledge Centre, Imperial College London, London SW7 2AZ, UK., Shaw WM; Centre for Synthetic Biology and Innovation, Imperial College London, London SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK., Ho JCH; Centre for Synthetic Biology and Innovation, Imperial College London, London SW7 2AZ, UK.; Department of Life Sciences, Imperial College London, London SW7 2AZ, UK., McKiernan RM; Centre for Synthetic Biology and Innovation, Imperial College London, London SW7 2AZ, UK.; Department of Life Sciences, Imperial College London, London SW7 2AZ, UK., Ellis T; Centre for Synthetic Biology and Innovation, Imperial College London, London SW7 2AZ, UK.; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
Publikováno v:
Nature communications [Nat Commun] 2017 May 04; Vol. 8, pp. 15202. Date of Electronic Publication: 2017 May 04.
Autor:
Ceroni F; Centre for Synthetic Biology and Innovation, Imperial College London, London, UK; Department of Bioengineering, Imperial College London, London, UK., Blount BA; Centre for Synthetic Biology and Innovation, Imperial College London, London, UK; Department of Bioengineering, Imperial College London, London, UK., Ellis T; Centre for Synthetic Biology and Innovation, Imperial College London, London, UK; Department of Bioengineering, Imperial College London, London, UK. Electronic address: t.ellis@imperial.ac.uk.
Publikováno v:
Cell systems [Cell Syst] 2016 Aug; Vol. 3 (2), pp. 116-117.