Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Blood-Brain Barrier / metabolism"'
Autor:
Matteo Battaglini, Natalia Feiner, Christos Tapeinos, Daniele De Pasquale, Carlotta Pucci, Attilio Marino, Martina Bartolucci, Andrea Petretto, Lorenzo Albertazzi, Gianni Ciofani
Publikováno v:
Battaglini, M, Feiner, N, Tapeinos, C, Pasquale, D D, Pucci, C, Marino, A, Bartolucci, M, Petretto, A, Albertazzi, L & Ciofani, G 2022, ' Combining confocal microscopy, dSTORM, and mass spectroscopy to unveil the evolution of the protein corona associated with nanostructured lipid carriers during blood–brain barrier crossing ', Nanoscale, vol. 14, no. 36, pp. 13292-13307 . https://doi.org/10.1039/d2nr00484d
Nanoscale
Nanoscale, 14(36), 13292-13307. Royal Society of Chemistry
Nanoscale
Nanoscale, 14(36), 13292-13307. Royal Society of Chemistry
Upon coming into contact with the biological environment, nanostructures are immediately covered by biomolecules, particularly by proteins forming the so-called “protein corona” (PC). The phenomenon of PC formation has gained great attention in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f70527927efa03a862c02e02ac9c83
https://research.tue.nl/en/publications/126cfd1c-f8b1-4d15-b80d-b982209d3a4e
https://research.tue.nl/en/publications/126cfd1c-f8b1-4d15-b80d-b982209d3a4e
Autor:
Maj Schneider Thomsen, Torben Moos
Publikováno v:
Thomsen, M S & Moos, T 2022, ' A novel bispecific antibody able to pass the blood-brain barrier and therapeutically engage within the brain ', Med (New York, N.Y.), vol. 3, no. 12, pp. 815-817 . https://doi.org/10.1016/j.medj.2022.11.006
The use of therapeutic antibodies for treating diseases in the CNS is hampered by the blood-brain barrier (BBB). In this issue, Edavettal et al.1 report on a novel bioengineered antibody not only capable of passing the BBB but also for intervening in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74b34ae35a950b1b57783bdf68d75cd
https://doi.org/10.1016/j.medj.2022.11.006
https://doi.org/10.1016/j.medj.2022.11.006
Autor:
Nielsen, Simone S E, Holst, Mikkel R, Langthaler, Kristine, Christensen, Sarah Christine, Bruun, Elisabeth Helena, Brodin, Birger, Nielsen, Morten S
Publikováno v:
Nielsen, S S E, Holst, M R, Langthaler, K, Bruun, E H, Brodin, B & Nielsen, M S 2023, ' Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells ', Fluids and Barriers of the CNS, vol. 20, no. 1, 2 . https://doi.org/10.1186/s12987-022-00404-1
Nielsen, S S E, Holst, M R, Langthaler, K, Christensen, S C, Bruun, E H, Brodin, B & Nielsen, M S 2023, ' Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells ', Fluids and Barriers of the CNS, vol. 20, no. 1, 2 . https://doi.org/10.1186/s12987-022-00404-1
Nielsen, S S E, Holst, M R, Langthaler, K, Christensen, S C, Bruun, E H, Brodin, B & Nielsen, M S 2023, ' Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells ', Fluids and Barriers of the CNS, vol. 20, no. 1, 2 . https://doi.org/10.1186/s12987-022-00404-1
The detailed mechanisms by which the transferrin receptor (TfR) and associated ligands traffic across brain capillary endothelial cells (BECs) of the CNS-protective blood–brain barrier constitute an important knowledge gap within maintenance and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a20208770ed7e5039e7928a39b8cc0b
https://curis.ku.dk/ws/files/332687129/Fulltext.pdf
https://curis.ku.dk/ws/files/332687129/Fulltext.pdf
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol. 11, No 1 (2021) P. 18137
Scientific Reports
Scientific Reports, Vol. 11, No 1 (2021) P. 18137
Scientific Reports
Despite Paraquat (PQ) being banned in several countries, it is still one of the most commonly used herbicides in agriculture. This compound is known to induce damaging effects on human and animal brain cells by generating Reactive Oxygen Species (ROS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f726193cd36deafe615910a48ce44729
https://doaj.org/article/084e55285876488aafdac7ec4a55a5eb
https://doaj.org/article/084e55285876488aafdac7ec4a55a5eb
Autor:
Diana Hudecz, Molly C. McCloskey, Sandra Vergo, Søren Christensen, James L. McGrath, Morten S. Nielsen
Publikováno v:
Hudecz, D, McCloskey, M C, Vergo, S, Christensen, S, McGrath, J L & Nielsen, M S 2023, ' Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device ', International Journal of Molecular Sciences, vol. 24, no. 6, 5624 . https://doi.org/10.3390/ijms24065624
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5624
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5624
Understanding the vesicular trafficking of receptors and receptor ligands in the brain capillary endothelium is essential for the development of the next generations of biologics targeting neurodegenerative diseases. Such complex biological questions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd913f90c581bcc40f37899a5c2504b
https://doi.org/10.3390/ijms24065624
https://doi.org/10.3390/ijms24065624
Autor:
Stephanie M. Robert, Benjamin C. Reeves, Emre Kiziltug, Phan Q. Duy, Jason K. Karimy, M. Shahid Mansuri, Arnaud Marlier, Garrett Allington, Ana B.W. Greenberg, Tyrone DeSpenza, Amrita K. Singh, Xue Zeng, Kedous Y. Mekbib, Adam J. Kundishora, Carol Nelson-Williams, Le Thi Hao, Jinwei Zhang, TuKiet T. Lam, Rashaun Wilson, William E. Butler, Michael L. Diluna, Philip Feinberg, Dorothy P. Schafer, Kiavash Movahedi, Allen Tannenbaum, Sunil Koundal, Xinan Chen, Helene Benveniste, David D. Limbrick, Steven J. Schiff, Bob S. Carter, Murat Gunel, J. Marc Simard, Richard P. Lifton, Seth L. Alper, Eric Delpire, Kristopher T. Kahle
Publikováno v:
Cell. 186:764-785.e21
The choroid plexus (ChP) is the blood-cerebrospinal fluid (CSF) barrier and the primary source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks drug treatments due to obscure pathobiology. Our integrated, multi-omic inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa40304436e8243fc55f6af7e4a0705
https://doi.org/10.1016/j.cell.2023.01.017
https://doi.org/10.1016/j.cell.2023.01.017
Autor:
Jan C. M. van Hest, Edwin de Jong, Loai K. E. A. Abdelmohsen, Inge S. Zuhorn, David S. Williams
Publikováno v:
Journal of Controlled Release, 289, 14-22. Elsevier
Journal of Controlled Release, 289, 14-22. Elsevier Bedrijfsinformatie b.v.
Journal of Controlled Release, 289, 14-22. Elsevier Bedrijfsinformatie b.v.
The delivery of therapeutics to the brain is greatly hampered by the blood-brain barrier (BBB). The use of nanoparticles that can cross the BBB via the process of receptor-mediated transcytosis at blood-brain barrier endothelial cells seems a promisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65ad730585c17728a9201fc0e0c154e
https://doi.org/10.1016/j.jconrel.2018.09.015
https://doi.org/10.1016/j.jconrel.2018.09.015
Autor:
de Gooijer, Mark C, de Vries, Nienke A, Buckle, Tessa, Buil, Levi C M, Beijnen, Jos H, Boogerd, Willem, van Tellingen, Olaf, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 7, Pp 710-720 (2018)
Neoplasia, 20(7), 710. Elsevier
Neoplasia (New York, N.Y.)
Neoplasia, 20(7), 710. Elsevier
Neoplasia (New York, N.Y.)
The anticancer drug temozolomide is the only drug with proven activity against high-grade gliomas and has therefore become a part of the standard treatment of these tumors. P-glycoprotein (P-gp; ABCB1) and breast cancer resistance protein (BCRP; ABCG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172288b7db60137160830a6682e4d13e
https://doi.org/10.1016/j.neo.2018.05.001
https://doi.org/10.1016/j.neo.2018.05.001
Autor:
Amélie Montané, Vincent Degos, Rebecca K. Holloway, Valérie C. Besson, Olivier Baud, David H. Rowitch, Pierre Gressens, A. David Edwards, Rahma Hassan-Abdi, Henrik Hagberg, Bobbi Fleiss, Nadia Soussi-Yanicostas, Sophie Lebon, Enrico Petretto, Gareth Ball, Tifenn Le Charpentier, Fabrice Chrétien, Andrée Delahaye-Duriez, Olivier Hennebert, Zsolt Csaba, Paul Aljabar, Anne-Laure Schang, Alka Saxena, Juliette Van Steenwinckel, Veronique E. Miron, Michelle L. Krishnan, Stéphanie Sigaut, Claire Leconte, Franck Verdonk, Cindy Bokobza, Leslie Schwendimann, Walter Birchmeier
Publikováno v:
Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2019, 42 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain-A Journal of Neurology, 2019, 42 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain-A Journal of Neurology, Oxford University Press (OUP), 2019, 142 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain
Brain, Vol. 142, No 12 (2019) pp. 3806-3833
Van Steenwinckel, J, Schang, A-L, Krishnan, M L, Degos, V, Delahaye-Duriez, A, Bokobza, C, Csaba, Z, Verdonk, F, Montané, A, Sigaut, S, Hennebert, O, Lebon, S, Schwendimann, L, Le Charpentier, T, Hassan-Abdi, R, Ball, G, Aljabar, P, Saxena, A, Holloway, R K, Birchmeier, W, Baud, O, Rowitch, D, Miron, V, Chretien, F, Leconte, C, Besson, V C, Petretto, E G, Edwards, A D, Hagberg, H, Soussi-Yanicostas, N, Fleiss, B & Gressens, P 2019, ' Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain ', Brain, vol. 142, no. 12, pp. 3806–3833 . https://doi.org/10.1093/brain/awz319
Van Steenwinckel, J, Schang, A-L, Krishnan, M L, Degos, V, Delahaye-Duriez, A, Bokobza, C, Csaba, Z, Verdonk, F, Montané, A, Sigaut, S, Hennebert, O, Lebon, S, Schwendimann, L, Le Charpentier, T, Hassan-Abdi, R, Ball, G, Aljabar, P, Saxena, A, Holloway, R K, Birchmeier, W, Baud, O, Rowitch, D, Miron, V, Chretien, F, Leconte, C, Besson, V C, Petretto, E G, Edwards, A D, Hagberg, H, Soussi-Yanicostas, N, Fleiss, B & Gressens, P 2019, ' Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain ', Brain : a journal of neurology, vol. 142, no. 12, pp. 3806–3833 . https://doi.org/10.1093/brain/awz319
Brain-A Journal of Neurology, Oxford University Press (OUP), 2019, 42 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain-A Journal of Neurology, 2019, 42 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain-A Journal of Neurology, Oxford University Press (OUP), 2019, 142 (12), pp.3806-3833. ⟨10.1093/brain/awz319⟩
Brain
Brain, Vol. 142, No 12 (2019) pp. 3806-3833
Van Steenwinckel, J, Schang, A-L, Krishnan, M L, Degos, V, Delahaye-Duriez, A, Bokobza, C, Csaba, Z, Verdonk, F, Montané, A, Sigaut, S, Hennebert, O, Lebon, S, Schwendimann, L, Le Charpentier, T, Hassan-Abdi, R, Ball, G, Aljabar, P, Saxena, A, Holloway, R K, Birchmeier, W, Baud, O, Rowitch, D, Miron, V, Chretien, F, Leconte, C, Besson, V C, Petretto, E G, Edwards, A D, Hagberg, H, Soussi-Yanicostas, N, Fleiss, B & Gressens, P 2019, ' Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain ', Brain, vol. 142, no. 12, pp. 3806–3833 . https://doi.org/10.1093/brain/awz319
Van Steenwinckel, J, Schang, A-L, Krishnan, M L, Degos, V, Delahaye-Duriez, A, Bokobza, C, Csaba, Z, Verdonk, F, Montané, A, Sigaut, S, Hennebert, O, Lebon, S, Schwendimann, L, Le Charpentier, T, Hassan-Abdi, R, Ball, G, Aljabar, P, Saxena, A, Holloway, R K, Birchmeier, W, Baud, O, Rowitch, D, Miron, V, Chretien, F, Leconte, C, Besson, V C, Petretto, E G, Edwards, A D, Hagberg, H, Soussi-Yanicostas, N, Fleiss, B & Gressens, P 2019, ' Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain ', Brain : a journal of neurology, vol. 142, no. 12, pp. 3806–3833 . https://doi.org/10.1093/brain/awz319
International audience; Microglia of the developing brain have unique functional properties but how their activation states are regulated is poorly understood. Inflammatory activation of microglia in the still-developing brain of preterm-born infants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5010c4ea37526701c318b122a40130
https://www.repository.cam.ac.uk/handle/1810/301606
https://www.repository.cam.ac.uk/handle/1810/301606
Autor:
Emre Guney, Mahmoud H. Elbatreek, Harald H.H.W. Schmidt, Jan Baumbach, Javier Egea, Simon J. Larsen, Vanessa Gómez-Rangel, Ana I. Casas, Pamela W. M. Kleikers, Manuela G. López, Ahmed A. Hassan
Publikováno v:
Casas, A I, Hassan, A A, Larsen, S J, Gomez-Rangel, V, Elbatreek, M, Kleikers, P W M, Guney, E, Egea, J, López, M G, Baumbach, J & Schmidt, H H H W 2019, ' From single drug targets to synergistic network pharmacology in ischemic stroke ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 14, pp. 7129-7136 . https://doi.org/10.1073/pnas.1820799116
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 116(14), 7129-7136. National Academy of Sciences
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 116(14), 7129-7136. National Academy of Sciences
Proceedings of the National Academy of Sciences
Significance Current one drug–one target–one disease approaches in drug discovery have become increasingly inefficient. Network pharmacology defines disease mechanisms as networks best targeted by multiple, synergistic drugs. Using the high unmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bd3be0432e66a4fc3c69b16682fec9
https://findresearcher.sdu.dk:8443/ws/files/151606865/From_single_drug_targets_to_synergistic_network_pharmacology_in_ischemic_stroke.pdf
https://findresearcher.sdu.dk:8443/ws/files/151606865/From_single_drug_targets_to_synergistic_network_pharmacology_in_ischemic_stroke.pdf