Výsledky vyhledávání - "Blood clotting factor 8"

İntron 22 Mutasyon Taşıyıcısı Ağır Hemofili A Hastalarında CTLA-4 ve TNF-? Gen Polimorfizmlerinin İnhibitör Gelişimi Üzerine Etkisi: Analitik Bir Araştırma

Autor: Mehdiyeva H., Işik E., Köse M., Akgün B., Durmuş B., Alpay A., Kavakli K.

Objective: The development of neutralizing antibodies against in-fused factor VIII called inhibitor is the most challenging treatment complication in hemophilia A (HA) patients. Associated factors for inhibitor development are classified into 2 group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______9436::ef5000caa49ac2817bc2e645d2471cda
https://hdl.handle.net/11454/80041

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Classification of Recombinant Biologics in the EU: Divergence Between National Pharmacovigilance Centers

Autor: Klein, Kevin, De Bruin, Marie L., Broekmans, Andre W., Stolk, Pieter, Sub Pharmacoepidemiology, Sub Gen. Pharmacoepi and Clinical Pharm, Pharmacoepidemiology and Clinical Pharmacology

Publikováno v: Biodrugs
BioDrugs, 29(6), 373. Adis International Ltd

Background and Objective Biological medicinal products (biologics) are subject to specific pharmacovigilance requirements to ensure that biologics are identifiable by brand name and batch number in adverse drug reaction (ADR) reports. Since Member St

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cff2fb1cf7f477e25087ef8de2eafa
http://europepmc.org/articles/PMC4684580

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Von Willebrand disease and other bleeding disorders in women: consensus on diagnosis and management from an international expert panel

Autor: Rezan Abdul-Kadir, Andra H. James, Augusto B. Federici, Susan Halimeh, Peter A. Kouides, Rochelle Winikoff, Mans Edlund, Flora Peyvandi, Pieter Willem Kamphuisen, Barbara A. Konkle, Claire McLintock, Oscar Martínez-Perez

Publikováno v: American journal of obstetrics and gynecology, 201(1), 12.e1-12.e8. Mosby Inc.
American Journal of Obstetrics and Gynecology, 201(1), 12.e1-12.e8. MOSBY-ELSEVIER

Reproductive tract bleeding in women is a naturally occurring event during menstruation and childbirth. In women with menorrhagia, however, congenital bleeding disorders historically have been underdiagnosed. This consensus is intended to allow physi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4a98dc9c8d101eb47bbe6a3c32be75
https://doi.org/10.1016/j.ajog.2009.04.024

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Intensive peri-operative use of factor VIII and the Arg593 → Cys mutation are risk factors for inhibitor development in mild/moderate hemophilia A

Autor: Marjolein Peters, Corien L. Eckhardt, Pieter Willem Kamphuisen, L.A. Menke, J.H. Van Der Lee, Karin Fijnvandraat, Ronald B. Geskus, C. H. van Ommen

Publikováno v: Journal of thrombosis and haemostasis, 7(6), 930-937. Wiley-Blackwell
Journal of Thrombosis and Haemostasis, 7(6), 930-937. Wiley

Background: A severe and challenging complication in the treatment of hemophilia A is the development of inhibiting antibodies (inhibitors) directed towards factor VIII (FVIII). Inhibitors aggravate bleeding complications, disabilities and costs. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5c7d51c770b9be08db893684821611
https://doi.org/10.1111/j.1538-7836.2009.03357.x

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Low-dose immune tolerance induction for paediatric haemophilia patients with factor VIII inhibitors

Autor: Türkiz Gürsel, Hale Ören, Tülin Tiraje Celkan, T. Sayli, Elif Güler Kazanci, Kaan Kavakli, Birol Baytan, Ayşegül Ünüvar

Publikováno v: Haemophilia. 14:315-322

The development of an inhibitor against factor VIII (FVIII) is a serious complication in children with haemophilia A. Immune tolerance induction (ITI) therapy is generally considered to be the best approach to eradicate the inhibitor. In this paper,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8703146e320f5033f06d80e373a537
https://doi.org/10.1111/j.1365-2516.2007.01621.x

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Inflammation and hemostasis in older octogenarians: implication in 5-year survival

Autor: Cubedo J., Padró T., Formiga F., Ferrer A., Padrós G., Peña E., Badimon L.

Publikováno v: Translational Research
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Social changes and medical advances have increased longevity, but the conditions governing healthy vs unhealthy cardiovascular (CV) aging are not fully known. Factors beyond classical CV risk factors may have an important unrecognized value. We sough

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::e4a0a69aef63e378478a47efae498a64
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020087134&doi=10.1016/j.trsl.2017.04.003&partnerID=40&md5=9a3f8423e1a6b65d37d40d268b34a52d

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The impairment in daily life of obese haemophiliacs

Publikováno v: Haemophilia. 17(2):204-208

Obesity is a major health concern not only in the general population but also in patients with haemophilia. Little is known about the consequences of obesity for haemophilia patients. As obesity is an important risk factor for osteoarthritis, these e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::bc83ce13fa74781282caa6ef1a18b164
https://research.rug.nl/en/publications/f47f7401-5bb1-4ffd-b49a-ad7fb6892b6a

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The impairment in daily life of obese haemophiliacs

Publikováno v: Haemophilia. 17(2):204-208

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::834dd0f9f5233a5795535b1e25df943f
https://doi.org/10.1111/j.1365-2516.2010.02417.x

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Factor VIII gene (F8) mutation and inhibitor development in non-severe hemophilia A

Autor: De Groot-Eckhardt, C. L., Van Velzen, A. S., Peters, Marloes, Peerlinck, K., Oldenburg, J., Santagostino, E., Astermark, J., Van Heerde, W. L., Hermans, C., Morfini, M., Castaman, G., Haya, S., McRae, S., Reitter-Pfoertner, S. E., Kamphuisen, P. W., Van der Bom, J. G., Fijnvandraat, K. J.

Publikováno v: Journal of Thrombosis and Haemostasis, 11, 33-33. Wiley

Background: The development of neutralizing antibodies (inhibitors) towards factor VIII is a major complication in non-severe hemophilia A, profoundly aggravating the bleeding pattern. Identification of high risk patients is hampered by lack of data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::c8f6b4bb361616498fe86ab3927b7c04
https://research.rug.nl/en/publications/93fb8d43-93cd-4387-b97b-d6b7ba4d3797

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