Zobrazeno 1 - 10
of 2 772
pro vyhledávání: '"Blood brain barrier (BBB)"'
Autor:
Pavel A. Libet, Leonid Y. Polynkin, Mikis R. Saridis, Egor V. Yakovlev, Sofia A. Korsakova, Alla B. Salmina, Anton S. Averchuk, Natalia A. Rozanova, Stanislav O. Yurchenko
Publikováno v:
Micro and Nano Systems Letters, Vol 12, Iss 1, Pp 1-12 (2024)
Abstract Brain-on-a-chip is an emerging field involving microfluidic devices capable of mimicking the structure and function of the human brain. Existing research often focuses on single barriers, such as the blood–brain barrier or blood–cerebros
Externí odkaz:
https://doaj.org/article/179920249f524259bde2813261e16e9a
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Status epilepticus (SE) is a common severe neurological emergency. Cerebral edema caused by SE is unavoidable and may exacerbate epilepsy. Recent studies have identified cerebrospinal fluid (CSF) as a crucial fluid source of initi
Externí odkaz:
https://doaj.org/article/0902368fcc64497aa5909108eb4bf869
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 15, Iss 1, Pp 1400-1414 (2024)
Central nervous system diseases negatively affect patients and society. Providing successful noninvasive treatments for these diseases is challenging because of the presence of the blood–brain barrier. While protecting the brain’s homeostasis, th
Externí odkaz:
https://doaj.org/article/4f97c1910f18489eac6099561356da45
Truncated mini LRP1 transports cargo from luminal to basolateral side across the blood brain barrier
Autor:
Laura Fritzen, Katharina Wienken, Lelia Wagner, Magdalena Kurtyka, Katharina Vogel, Jakob Körbelin, Sascha Weggen, Gert Fricker, Claus U. Pietrzik
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-23 (2024)
Abstract Background The most crucial area to focus on when thinking of novel pathways for drug delivery into the CNS is the blood brain barrier (BBB). A number of nanoparticulate formulations have been shown in earlier research to target receptors at
Externí odkaz:
https://doaj.org/article/6959b746fc7b4f43abec3dada8978c0c
Autor:
Xin Wen, Zhiying Shao, Xueting Chen, Hongmei Liu, Hui Qiu, Xin Ding, Debao Qu, Hui Wang, Andrew Z. Wang, Longzhen Zhang
Publikováno v:
Radiation Oncology, Vol 19, Iss 1, Pp 1-20 (2024)
Abstract Glioblastoma (GBM), the most common primary brain malignancy in adults, is notoriously difficult to treat due to several factors: tendency to be radiation resistant, the presence of the blood brain barrier (BBB) which limits drug delivery an
Externí odkaz:
https://doaj.org/article/ac79f3ab66934c71b016444172807920
Autor:
Takahiro Hobara, Yujiro Higuchi, Mari Yoshida, Masahito Suehara, Masahiro Ando, Jun-Hui Yuan, Akiko Yoshimura, Fumikazu Kojima, Eiji Matsuura, Yuji Okamoto, Jun Mitsui, Shoji Tsuji, Hiroshi Takashima
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract Primary familial brain calcification (PFBC) is a genetic neurological disorder characterized by symmetric brain calcifications that manifest with variable neurological symptoms. This study aimed to explore the genetic basis of PFBC and eluci
Externí odkaz:
https://doaj.org/article/7d9125ca83074ee1806a6efaf22d448d
Publikováno v:
Brain Research Bulletin, Vol 220, Iss , Pp 111137- (2025)
Postoperative cognitive dysfunction (POCD) is a common complication in patients who undergo anesthesia in different types of surgeries. Emerging evidence implicates elevated beta-amyloid (Aβ) in the pathogenesis of POCD. Meanwhile, Dexmedetomidine (
Externí odkaz:
https://doaj.org/article/16dd0630de094237aaf17b06d3a10100
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Recent development of amyloid-β (Aβ)-targeted immunotherapies for Alzheimer’s disease (AD) have highlighted the need for accurate diagnostic methods. Antibody-based positron emission tomography (PET) ligands are well suited for this purpose as th
Externí odkaz:
https://doaj.org/article/e26e8d4cee664eda81a36e31dae1d509
Autor:
Weili Li, Wenbo Hu, Shuhua Yuan, Jiahao Chen, Qi Wang, Jiayue Ding, Zhiying Chen, Zhifeng Qi, Ju Han
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 21 (2024)
BACKGROUND Recent advancements in animal studies have demonstrated the potential of normobaric hyperoxia (NBO) as a promising intervention for preserving the integrity of the blood–brain barrier (BBB). However, there is still limited understanding
Externí odkaz:
https://doaj.org/article/4c6783144a4f4a7eac803fc35dbfc72b
Autor:
Yajie Hu, Yunguang Hu, Anguo Yin, Yaming Lv, Jiang Li, Jingyuan Fan, Baojiang Qian, Jie Song, Yunhui Zhang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The mechanisms underlying pathological changes in the central nervous system (CNS) following Coxsackievirus A16 (CV-A16) infection have not yet been elucidated. IFN-γ-inducible protein-10 (IP-10) is often used as a predictive factor to monitor early
Externí odkaz:
https://doaj.org/article/dee796700dfc4485a86ea578041bf5dc