A post-translational modification of human Norovirus capsid protein attenuates glycan binding

Autor: Philipp H. O. Mayer, Charlotte Uetrecht, Thilo Stehle, Lena Lisbeth Grimm, Bärbel S. Blaum, Kasper D. Rand, Alvaro Mallagaray, Esben Trabjerg, Thomas Peters, Robert Creutznacher, Jose Maria Orduña, Jasmin Dülfer

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Mallagaray, A, Creutznacher, R, Dülfer, J, Mayer, P H O, Grimm, L L, Orduña, J M, Trabjerg, E, Stehle, T, Rand, K D, Blaum, B S, Uetrecht, C & Peters, T 2019, ' A post-translational modification of human Norovirus capsid protein attenuates glycan binding ', Nature Communications, vol. 10, no. 1, 1320 . https://doi.org/10.1038/s41467-019-09251-5
Nature Communications, 10 (1)

Attachment of human noroviruses to histo blood group antigens (HBGAs) is essential for infection, but how this binding event promotes the infection of host cells is unknown. Here, we employ protein NMR experiments supported by mass spectrometry and c

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https://doaj.org/article/c8982557c21047d891ebe906ae91a8ed