Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Autor: Gemma Odena, Jelena Mann, Lia R. Edmunds, Juan Pablo Arab, Aaron Bell, Stephen R. Atkinson, Pau Sancho-Bru, Satdarshan P.S. Monga, Peter Stärkel, Joel P. Gue, Maria U. Latasa, Juan Caballería, Matías A. Avila, Alexandre Louvet, Sheng Cao, Juan Luis Gomez, Claes Wahlestedt, Marsha Y. Morgan, Juan José Lozano, Philippe Mathurin, José Altamirano, Derek J. Van Booven, Laurent Dubuquoy, Ramon Bataller, Ilya O. Blokhin, Shinji Furuya, Constantino Fondevilla, D. Lansing Taylor, Veronica Massey, Ivan Rusyn, Mark Thursz, Michael J. Jurczak, Tomás J. Aragón, Carolin Lackner, Lawrence Vernetti, Vijay H. Shah, Josepmaria Argemi, Meritxell Ventura-Cots, Joaquín Cabezas, Carmen Berasain

Publikováno v: Nature Communications
Nature Communications, 2019, Nature Communications, 10 (1), pp.3126. ⟨10.1038/s41467-019-11004-3⟩
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Scientia
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Nature Communications, Nature Publishing Group, 2019, Nature Communications, 10 (1), pp.3126. ⟨10.1038/s41467-019-11004-3⟩
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Nature communications, Vol. 10, no. 1, p. 3126 [1-19] (2019)

Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900dfe4b907dbab0ee9b21afc4bd0024
https://ddd.uab.cat/record/223727

Author Correction: Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis.

Autor: Argemi J; Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, 15261, USA.; Liver Unit, Clínica Universidad de Navarra, University of Navarra, Pamplona, 31008, Spain., Latasa MU; Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, 31008, Spain., Atkinson SR; Division of Digestive Diseases, Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK., Blokhin IO; Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, 33136, USA., Massey V; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA., Gue JP; Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, 15261, USA., Cabezas J; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA.; Departament of Hepatology, Marqués de Valdecilla University Hospital, Santander, 39008, Spain., Lozano JJ; Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, 28029, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, 08036, Spain., Van Booven D; John P. Hussman Institute of Human Genomics. Miller School of Medicine, University of Miami, Miami, FL, 33136, USA., Bell A; Departments of Pathology and Medicine, Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA., Cao S; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA., Vernetti LA; University of Pittsburgh Drug Discovery Institute, Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Arab JP; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA.; Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile., Ventura-Cots M; Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, 15261, USA., Edmunds LR; Department of Medicine, Division of Endocrinology and Metabolism, Center for Metabolic and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Fondevila C; Liver Transplant Unit, Department of Surgery, Hospital Clinic, University of Barcelona, Barcelona, 08036, Spain., Stärkel P; Service d'Hépato-gastroentérologie, Cliniques Universitaires Saint-Luc and Laboratory of Hepatogastroenterology, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, 1200, Belgium., Dubuquoy L; Service des Maladies de l'appareil digestif, CHU Lille. Inserm LIRIC - UMR995, University of Lille, Lille, 59000, France., Louvet A; Service des Maladies de l'appareil digestif, CHU Lille. Inserm LIRIC - UMR995, University of Lille, Lille, 59000, France., Odena G; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA., Gomez JL; Departments of Pathology and Medicine, Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA., Aragon T; Department of Gene Therapy and Regulation, Center for Applied Medical Research, University of Navarra, Pamplona, 31008, Spain., Altamirano J; Liver Unit, Department of Internal Medicine, Vall d'Hebron Institut de Recerca. Internal Medicine Department, Hospital Quiron Salud, Barcelona, 08035, Spain., Caballeria J; Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, 28029, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, 08036, Spain., Jurczak MJ; Department of Medicine, Division of Endocrinology and Metabolism, Center for Metabolic and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Taylor DL; University of Pittsburgh Drug Discovery Institute, Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Berasain C; Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, 31008, Spain.; Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, 28029, Spain., Wahlestedt C; Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, 33136, USA., Monga SP; Departments of Pathology and Medicine, Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA., Morgan MY; UCL Institute for Liver and Digestive Health, Division of Medicine, Royal Free Campus, University College London, London, WC1E 6BT, UK., Sancho-Bru P; Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, 28029, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, 08036, Spain., Mathurin P; Service des Maladies de l'appareil digestif, CHU Lille. Inserm LIRIC - UMR995, University of Lille, Lille, 59000, France., Furuya S; Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77845, USA., Lackner C; Medical University of Graz, Institute of Pathology, Graz, 8036, Austria., Rusyn I; Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77845, USA., Shah VH; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA., Thursz MR; Division of Digestive Diseases, Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK., Mann J; Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Avila MA; Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, 31008, Spain.; Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, 28029, Spain., Bataller R; Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, 15261, USA. bataller@pitt.edu.; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA. bataller@pitt.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Feb 10; Vol. 14 (1), pp. 757. Date of Electronic Publication: 2023 Feb 10.

Molecular mechanisms of psychiatric diseases.

Autor: Blokhin IO; Center for Therapeutic Innovation, University of Miami, Miami, FL, United States of America; Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL, United States of America; Jackson Memorial Hospital, Miami, FL, United States of America., Khorkova O; OPKO Health Inc., Miami, FL, United States of America., Saveanu RV; Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL, United States of America., Wahlestedt C; Center for Therapeutic Innovation, University of Miami, Miami, FL, United States of America; Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL, United States of America. Electronic address: cwahlestedt@med.miami.edu.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2020 Dec; Vol. 146, pp. 105136. Date of Electronic Publication: 2020 Oct 17.

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease.

Autor: Timmons JA; Division of Genetics and Molecular Medicine, King's College London, London, UK.; Scion House, Stirling University Innovation Park, Stirling, UK., Atherton PJ; School of Medicine, Derby Royal Hospital, Derby, UK., Larsson O; Department of Oncology-Pathology, Science For Life Laboratory, Stockholm, Sweden., Sood S; Division of Genetics and Molecular Medicine, King's College London, London, UK., Blokhin IO; Miller School of Medicine, University of Miami, USA., Brogan RJ; Scion House, Stirling University Innovation Park, Stirling, UK., Volmar CH; Miller School of Medicine, University of Miami, USA., Josse AR; McMaster University, Canada., Slentz C; Duke University School of Medicine, Durham, USA., Wahlestedt C; Department of Oncology-Pathology, Science For Life Laboratory, Stockholm, Sweden., Phillips SM; McMaster University, Canada., Phillips BE; School of Medicine, Derby Royal Hospital, Derby, UK., Gallagher IJ; Scion House, Stirling University Innovation Park, Stirling, UK.; School of Health Sciences and Sport, University of Stirling, Stirling, UK., Kraus WE; Duke University School of Medicine, Durham, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2018 Sep 06; Vol. 46 (15), pp. 7772-7792.

Endothelial PPAR-γ protects against vascular thrombosis by downregulating P-selectin expression.

Autor: Jin H; From the Departments of Internal Medicine (H.J., M.A.G., I.O.B., K.M.W., A.K.C., C.D.S., S.R.L.) and Pharmacology (P.K., H.L.K., C.D.S.), Interdisciplinary Graduate Program in Molecular and Cellular Biology (I.O.B.), University of Iowa Carver College of Medicine, Iowa City., Gebska MA; From the Departments of Internal Medicine (H.J., M.A.G., I.O.B., K.M.W., A.K.C., C.D.S., S.R.L.) and Pharmacology (P.K., H.L.K., C.D.S.), Interdisciplinary Graduate Program in Molecular and Cellular Biology (I.O.B.), University of Iowa Carver College of Medicine, Iowa City., Blokhin IO; From the Departments of Internal Medicine (H.J., M.A.G., I.O.B., K.M.W., A.K.C., C.D.S., S.R.L.) and Pharmacology (P.K., H.L.K., C.D.S.), Interdisciplinary Graduate Program in Molecular and Cellular Biology (I.O.B.), University of Iowa Carver College of Medicine, Iowa City., Wilson KM; From the Departments of Internal Medicine (H.J., M.A.G., I.O.B., K.M.W., A.K.C., C.D.S., S.R.L.) and Pharmacology (P.K., H.L.K., C.D.S.), Interdisciplinary Graduate Program in Molecular and Cellular Biology (I.O.B.), University of Iowa Carver College of Medicine, Iowa City., Ketsawatsomkron P; From the Departments of Internal Medicine (H.J., M.A.G., I.O.B., K.M.W., A.K.C., C.D.S., S.R.L.) and Pharmacology (P.K., H.L.K., C.D.S.), Interdisciplinary Graduate Program in Molecular and Cellular Biology (I.O.B.), University of Iowa Carver College of Medicine, Iowa City., Chauhan AK; From the Departments of Internal Medicine (H.J., M.A.G., I.O.B., K.M.W., A.K.C., C.D.S., S.R.L.) and Pharmacology (P.K., H.L.K., C.D.S.), Interdisciplinary Graduate Program in Molecular and Cellular Biology (I.O.B.), University of Iowa Carver College of Medicine, Iowa City., Keen HL; From the Departments of Internal Medicine (H.J., M.A.G., I.O.B., K.M.W., A.K.C., C.D.S., S.R.L.) and Pharmacology (P.K., H.L.K., C.D.S.), Interdisciplinary Graduate Program in Molecular and Cellular Biology (I.O.B.), University of Iowa Carver College of Medicine, Iowa City., Sigmund CD; From the Departments of Internal Medicine (H.J., M.A.G., I.O.B., K.M.W., A.K.C., C.D.S., S.R.L.) and Pharmacology (P.K., H.L.K., C.D.S.), Interdisciplinary Graduate Program in Molecular and Cellular Biology (I.O.B.), University of Iowa Carver College of Medicine, Iowa City., Lentz SR; From the Departments of Internal Medicine (H.J., M.A.G., I.O.B., K.M.W., A.K.C., C.D.S., S.R.L.) and Pharmacology (P.K., H.L.K., C.D.S.), Interdisciplinary Graduate Program in Molecular and Cellular Biology (I.O.B.), University of Iowa Carver College of Medicine, Iowa City. steven-lentz@uiowa.edu.

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2015 Apr; Vol. 35 (4), pp. 838-44. Date of Electronic Publication: 2015 Feb 12.