Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.

Autor: Redick SD; Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Leehy L; Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Rittenhouse AR; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA., Blodgett DM; Diabetes Center of Excellence, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.; Math and Science Division, Babson College, Wellesley, MA, USA., Derr AG; Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA., Kucukural A; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA., Garber MG; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA., Shultz LD; The Jackson Laboratory, Bar Harbor, ME, USA., Greiner DL; Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Wang JP; Diabetes Center of Excellence, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Harlan DM; Diabetes Center of Excellence, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Bortell R; Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Jurczyk A; Diabetes Center of Excellence, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Jan; Vol. 34 (1), pp. 1901-1911. Date of Electronic Publication: 2019 Dec 10.

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

Autor: Brissova M; Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: marcela.brissova@vanderbilt.edu., Haliyur R; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Saunders D; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Shrestha S; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Dai C; Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA., Blodgett DM; Department of Medicine, Diabetes Division, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA; Math and Science Division, Babson College, Wellesley, MA 02457, USA., Bottino R; Institute of Cellular Therapeutics, Allegheny-Singer Research Institute, Allegheny Health Network, Pittsburgh, PA, USA., Campbell-Thompson M; Department of Pathology, University of Florida Diabetes Institute, College of Medicine, Gainesville, FL, USA., Aramandla R; Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA., Poffenberger G; Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA., Lindner J; Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA., Pan FC; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., von Herrath MG; Type 1 Diabetes Center, the La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA., Greiner DL; Department of Medicine, Diabetes Division, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA., Shultz LD; The Jackson Laboratory, Bar Harbor, ME, USA., Sanyoura M; Departments of Medicine and Pediatrics, Section of Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, IL, USA., Philipson LH; Departments of Medicine and Pediatrics, Section of Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, IL, USA., Atkinson M; Department of Pathology, University of Florida Diabetes Institute, College of Medicine, Gainesville, FL, USA., Harlan DM; Department of Medicine, Diabetes Division, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA., Levy SE; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Prasad N; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Stein R; Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Powers AC; Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA. Electronic address: al.powers@vanderbilt.edu.

Publikováno v: Cell reports [Cell Rep] 2018 Mar 06; Vol. 22 (10), pp. 2667-2676.

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Autor: Babon JA; Department of Medicine, Division of Diabetes, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, USA., DeNicola ME; Department of Medicine, Division of Diabetes, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Blodgett DM; Department of Medicine, Division of Diabetes, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Crèvecoeur I; Laboratory for Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium., Buttrick TS; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Maehr R; Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Bottino R; Institute of Cellular Therapeutics, Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, USA.; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA., Naji A; Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA., Kaddis J; Department of Information Sciences, Beckman Research Institute, City of Hope, Duarte, California, USA., Elyaman W; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., James EA; Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA., Haliyur R; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Brissova M; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Overbergh L; Laboratory for Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium., Mathieu C; Laboratory for Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium., Delong T; Department of Immunology and Microbiology, University of Colorado School of Medicine, Denver, Anschutz Medical Campus, Aurora, Colorado, USA., Haskins K; Department of Immunology and Microbiology, University of Colorado School of Medicine, Denver, Anschutz Medical Campus, Aurora, Colorado, USA., Pugliese A; Diabetes Research Institute, University of Miami, Miami, Florida, USA., Campbell-Thompson M; Departments of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA., Mathews C; Departments of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA., Atkinson MA; Departments of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA., Powers AC; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA., Harlan DM; Department of Medicine, Division of Diabetes, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Kent SC; Department of Medicine, Division of Diabetes, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Publikováno v: Nature medicine [Nat Med] 2016 Dec; Vol. 22 (12), pp. 1482-1487. Date of Electronic Publication: 2016 Oct 31.

End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data.

Autor: Derr A; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA., Yang C; Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA., Zilionis R; Department of System Biology, Harvard Medical School, Boston, Massachusetts 02115, USA; Institute of Biotechnology, Vilnius University, LT 02241 Vilnius, Lithuania., Sergushichev A; Computer Technologies Department, ITMO University, Saint Petersburg, 197101, Russia; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri 63110, USA., Blodgett DM; Department of Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA., Redick S; Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA., Bortell R; Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA., Luban J; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA., Harlan DM; Department of Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA., Kadener S; Biological Chemistry Department, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel., Greiner DL; Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA., Klein A; Department of System Biology, Harvard Medical School, Boston, Massachusetts 02115, USA., Artyomov MN; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri 63110, USA., Garber M; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.

Publikováno v: Genome research [Genome Res] 2016 Oct; Vol. 26 (10), pp. 1397-1410. Date of Electronic Publication: 2016 Jul 28.

The pancreatic β-cell transcriptome and integrated-omics.

Autor: Blodgett DM; Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Cura AJ, Harlan DM

Publikováno v: Current opinion in endocrinology, diabetes, and obesity [Curr Opin Endocrinol Diabetes Obes] 2014 Apr; Vol. 21 (2), pp. 83-8.