Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Blevis-Bal Radhika M"'
Autor:
Dean Messing, Brian S. Hickory, Alan G. Benson, Matthew J. Saabye, Jeff Hitchcock, Heather M. Madsen, Devadas Balekudru, Shaun R. Selness, Richard C. Durley, Laura D. Marrufo, Gary D. Anderson, Li Xing, Kevin D. Jerome, Michael Hepperle, Christie Lance Christopher, Rajesh V. Devraj, Elizabeth G. Webb, Thomas Owen, Ravi G. Kurumbail, Edgardo Alvira, Jeffrey L. Hirsch, Joseph B. Monahan, Paul V. Rucker, Boehm Terri L, Blevis-Bal Radhika M, Huey S. Shieh, John K. Walker, John F. Schindler, Michele A. Promo, Win Naing, Sheri L. Bonar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4059-4065
A series of N-aryl pyridinone inhibitors of p38 mitogen activated protein (MAP) kinase were designed and prepared based on the screening hit SC-25028 (1) and structural comparisons to VX-745 (5). The focus of the investigation targeted the dependence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57328f6e5ea96fc972d684f2e92281c
https://doi.org/10.1016/j.bmcl.2011.04.120
https://doi.org/10.1016/j.bmcl.2011.04.120
Autor:
Sandra W. Curtiss, D. Joseph Rogier, Alan MacInnes, Brown David L, Mike B. Tollefson, Brian R. Bond, Yvette M. Fobian, Maddux Todd Michael, Dafydd R. Owen, Jeanne M. Rumsey, Brent V. Mischke, Jerry W. Cubbage, Alan G. Benson, Robert Hughes, Lena L Zhang, E. Jon Jacobsen, Steven E. Heasley, Joseph B. Moon, Ying Yu, John M. Molyneaux, Yi Zheng, Brad A. Acker, Blevis-Bal Radhika M, John N. Freskos, John K. Walker, Jennie L. Walgren
Publikováno v:
Journal of Medicinal Chemistry. 53:2656-2660
We recently described a novel series of aminopyridopyrazinones as PDE5 inhibitors. Efforts toward optimization of this series culminated in the identification of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::892c7788c8aa398973abd4f8bb5a78a5
https://doi.org/10.1021/jm901781q
https://doi.org/10.1021/jm901781q
Autor:
Maddux Todd Michael, Yvette M. Fobian, Alan G. Benson, Dafydd R. Owen, Brian R. Bond, Christopher Phillips, Brad A. Acker, E. Jon Jacobsen, Michael John Palmer, D. Joseph Rogier, John M. Molyneaux, Brent V. Mischke, John N. Freskos, Tracy J. Ringer, Andrew Simon Bell, Blevis-Bal Radhika M, Robert Hughes, David G. Brown, Steve E. Heasley, Joseph B. Moon, John K. Walker, Brown David L, William C. Stallings, Michael B. Tollefson, Alan MacInnes, Jerry W. Cubbage, Yung Yu, Margarita Rodriquez-Lens, Fox David Nathan Abraham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4088-4091
A new class of potent and selective PDE5 inhibitors is disclosed. Guided by X-ray crystallographic data, optimization of an HTS lead led to the discovery of a series of 2-aryl, (N8)-alkyl substituted-6-aminosubstituted pyrido[3,2b]pyrazinones which s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5005db6742e606fdadbf520ea66a63a9
https://doi.org/10.1016/j.bmcl.2009.06.012
https://doi.org/10.1016/j.bmcl.2009.06.012
Autor:
Mike B. Tollefson, Joseph B. Moon, Brent V. Mischke, E. Jon Jacobsen, D. Joseph Rogier, Alan G. Benson, Maddux Todd Michael, Brad A. Acker, Jeanne M. Rumsey, John N. Freskos, Blevis-Bal Radhika M, Alan MacInnes, Yi Zheng, Steve E. Heasley, Brown David L, John K. Walker, Yvette M. Fobian, Dafydd R. Owen, Jerry W. Cubbage, Robert Hughes, Ying Yu, John M. Molyneaux, Brian R. Bond
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(17)
We describe efforts to improve the pharmacokinetic profile of the aminopyridopyrazinone class of PDE5 inhibitors. These efforts led to the discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bba8721c0b4d57439e25992ba23e4b
https://pubmed.ncbi.nlm.nih.gov/19631533
https://pubmed.ncbi.nlm.nih.gov/19631533
Autor:
Alan MacInnes, E. Jon Jacobsen, Robert Hughes, Blevis-Bal Radhika M, Jennifer M. Williams, John K. Walker, Joseph B. Moon, Jeanne M. Rumsey, Brad A. Acker, Steve E. Heasley, Maddux Todd Michael, Dafydd R. Owen, Ying Yu, John M. Molyneaux, Jerry W. Cubbage, Brian R. Bond, Brown David L, Alan G. Benson, John N. Freskos, William C. Stallings, Brent V. Mischke, Yvette M. Fobian, D. Joseph Rogier, Yi Zheng, Mike B. Tollefson
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
Efforts to improve the potency and physical properties of the aminopyridiopyrazinone class of PDE5 inhibitors through modification of the core ring system are described. Five new ring systems are evaluated and features that impart improved potency an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c530b519c26bbcf215a387ac7749266
https://pubmed.ncbi.nlm.nih.gov/19539468
https://pubmed.ncbi.nlm.nih.gov/19539468
Autor:
Owen, Dafydd R., Walker, John K., Jon Jacobsen, E., Freskos, John N., Hughes, Robert O., Brown, David L., Bell, Andrew S., Brown, David G., Phillips, Christopher, Mischke, Brent V., Molyneaux, John M., Fobian, Yvette M., Heasley, Steve E., Moon, Joseph B., Stallings, William C., Joseph Rogier, D., Fox, David N.A., Palmer, Michael J., Ringer, Tracy, Rodriquez-Lens, Margarita, Cubbage, Jerry W., Blevis-Bal, Radhika M., Benson, Alan G., Acker, Brad A., Maddux, Todd M., Tollefson, Michael B., Bond, Brian R., MacInnes, Alan, Yu, Yung
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 August 2009 19(15):4088-4091