Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Blessy George"'
Publikováno v:
Clinical Dermatology Review, Vol 8, Iss 3, Pp 243-246 (2024)
Sexually transmitted diseases/infections (STDs/STIs) are one of major public health concern, and syphilis in today’s era is not an uncommon diagnosis. The rising trend of syphilis cases can be attributed to changes in sexual practices such as indiv
Externí odkaz:
https://doaj.org/article/524d4700615e4bbaac402c55e8146f34
Autor:
Blessy George, Xia Wen, Nickie Mercke, Madeleine Gomez, Cindy O’Bryant, Daniel W. Bowles, Yichun Hu, Susan L. Hogan, Melanie S. Joy, Lauren M. Aleksunes
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 571-576 (2020)
Proteins secreted into urine following tubular injury are being increasingly used as biomarkers of clinical and subclinical nephrotoxicity. In the present study, we sought to characterize the time-dependent urinary excretion of three promising biomar
Externí odkaz:
https://doaj.org/article/271201962f0e4c8eb0f71bfffcb20e5a
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6439 (2021)
The organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1) mediate the renal secretion of drugs. Recent studies suggest that ondansetron, a 5-HT3 antagonist drug used to prevent nausea and vomiting, can inhibit OCT2-
Externí odkaz:
https://doaj.org/article/00318440cf3b4bc0a5adedc0c6a4566e
Autor:
Cara Chang, Yichun Hu, Susan L. Hogan, Nickie Mercke, Madeleine Gomez, Cindy O’Bryant, Daniel W. Bowles, Blessy George, Xia Wen, Lauren M. Aleksunes, Melanie S. Joy
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 7, p 1333 (2017)
Nephrotoxicity is a dose limiting side effect associated with the use of cisplatin in the treatment of solid tumors. The degree of nephrotoxicity is dictated by the selective accumulation of cisplatin in renal tubule cells due to: (1) uptake by organ
Externí odkaz:
https://doaj.org/article/a2f341d86698450694d9f4ef1731047a
Publikováno v:
J Biochem Mol Toxicol
Since the discovery of calbindin release into the urine during renal injury, there has been growing interest in the utility of this protein as a biomarker of nephrotoxicity. However, little is known about the intrarenal regulation of the release and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f0ba8e7b46153d165c6a18d076d789
https://pubmed.ncbi.nlm.nih.gov/35403300
https://pubmed.ncbi.nlm.nih.gov/35403300
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 12
International Journal of Molecular Sciences, Vol 22, Iss 6439, p 6439 (2021)
Volume 22
Issue 12
International Journal of Molecular Sciences, Vol 22, Iss 6439, p 6439 (2021)
The organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1) mediate the renal secretion of drugs. Recent studies suggest that ondansetron, a 5-HT3 antagonist drug used to prevent nausea and vomiting, can inhibit OCT2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf39c6df840faaeefb4725d77ec9815
Autor:
Julie Beitz, Blessy George, Jian Wang, Christine P. Nguyen, Barbara Wesley, Annie Lumen, Victor Crentsil
Publikováno v:
npj Systems Biology and Applications, Vol 6, Iss 1, Pp 1-9 (2020)
NPJ Systems Biology and Applications
NPJ Systems Biology and Applications
Pregnancy is a period of significant change that impacts physiological and metabolic status leading to alterations in the disposition of drugs. Uncertainty in drug dosing in pregnancy can lead to suboptimal therapy, which can contribute to disease ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfce6da60dd4ee8c3e7aeaa3b99c1d4a
https://doi.org/10.1038/s41540-020-00157-3
https://doi.org/10.1038/s41540-020-00157-3
Autor:
Lauren M. Aleksunes, Nickie Mercke, Brian Buckley, Cindy L. O'Bryant, Yichun Hu, Madeleine Gomez, Susan L. Hogan, Daniel W. Bowles, Melanie S. Joy, Mustafa E Ibrahim, Blessy George, Cara Chang, Xia Wen
Publikováno v:
European Journal of Clinical Pharmacology. 75:51-57
PURPOSE: The ability to predict and detect clinical and subclinical nephrotoxicity early in the course of therapy has the potential to improve long-term outcomes in cancer patients receiving cisplatin chemotherapy. Pharmacokinetic parameters could se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1129fa944a9ee9188ed0254b02003de2
https://doi.org/10.1007/s00228-018-2552-z
https://doi.org/10.1007/s00228-018-2552-z
Autor:
Susan L. Hogan, Cindy L. O'Bryant, Yichun Hu, Blessy George, Madeleine Gomez, Xia Wen, Daniel W. Bowles, Melanie S. Joy, Lauren M. Aleksunes, Nickie Mercke
Publikováno v:
Clinical Pharmacology & Therapeutics. 101:510-518
The success of cisplatin-containing regimens to treat solid tumors is limited, in part, by nephrotoxicity. In rodents, several urinary proteins have emerged that are sensitive indicators of cisplatin-induced kidney injury. We sought to characterize t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbb5be993bb2779ba9757bd51649dc3
https://doi.org/10.1002/cpt.606
https://doi.org/10.1002/cpt.606
Autor:
Blessy George, Nickie Mercke, Lauren M. Aleksunes, Cindy L. O'Bryant, Yichun Hu, Daniel W. Bowles, Melanie S. Joy, Xia Wen, Madeleine Gomez, Susan L. Hogan
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 7, Iss, Pp 571-576 (2020)
Toxicology Reports, Vol 7, Iss, Pp 571-576 (2020)
Graphical abstract
Highlights • KIM-1, calbindin, and TFF3 are increased in urine of patients prescribed cisplatin. • KIM-1 concentrations remain elevated with subsequent cisplatin treatment cycles. • Calbindin concentrations increased onl
Highlights • KIM-1, calbindin, and TFF3 are increased in urine of patients prescribed cisplatin. • KIM-1 concentrations remain elevated with subsequent cisplatin treatment cycles. • Calbindin concentrations increased onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d075496c5a7681dc98334cefb46cc0
https://pubmed.ncbi.nlm.nih.gov/32382514
https://pubmed.ncbi.nlm.nih.gov/32382514