Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report.

Autor: Fortress AM; National Eye Institute, National Institutes of Health, Bethesda, MD, USA. ashley.fortress@nih.gov., Miyagishima KJ; Retinal Neurophysiology Section, National Eye Institute, NIH, Bethesda, MD, USA., Reed AA; National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Temple S; Neural Stem Cell Institute, Rensselaer, NY, USA., Clegg DO; Center for Stem Cell Biology and Engineering, University of California, Santa Barbara, CA, USA., Tucker BA; Institute for Vision Research, Department of Ophthalmology and Visual Science, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Blenkinsop TA; Ophthalmology Cell Development and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Harb G; Cellino Biotech, Cambridge, MA, USA., Greenwell TN; National Eye Institute, National Institutes of Health, Bethesda, MD, USA. thomas.greenwell@nih.gov., Ludwig TE; WiCell Research Institute, Madison, WI, USA., Bharti K; Ocular and Stem Cell Translational Research, National Eye Institute, NIH, Bethesda, MD, USA. kapil.bharti@nih.gov.

Publikováno v: Stem cell research & therapy [Stem Cell Res Ther] 2023 Mar 29; Vol. 14 (1), pp. 53. Date of Electronic Publication: 2023 Mar 29.

A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway.

Autor: Parikh BH; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Liu Z; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Eye Research Institute (SERI), Singapore, Singapore., Blakeley P; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lin Q; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Singh M; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ong JY; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ho KH; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lai JW; Science, Mathematics and Technology Cluster, Singapore University of Technology and Design (SUTD), Singapore, Singapore., Bogireddi H; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tran KC; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lim JYC; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Materials Science and Engineering, National University of Singapore, Singapore, Singapore., Xue K; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Al-Mubaarak A; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Yang B; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., R S; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Regha K; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Wong DSL; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan QSW; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Zhang Z; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Jeyasekharan AD; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Barathi VA; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Eye Research Institute (SERI), Singapore, Singapore.; Academic Clinical Program in Ophthalmology, Duke-NUS Medical School, Singapore, Singapore., Yu W; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Cheong KH; Science, Mathematics and Technology Cluster, Singapore University of Technology and Design (SUTD), Singapore, Singapore., Blenkinsop TA; Department of Cellular, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hunziker W; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lingam G; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Eye Research Institute (SERI), Singapore, Singapore.; Department of Ophthalmology, National University Hospital, Singapore, Singapore., Loh XJ; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. lohxj@imre.a-star.edu.sg.; Department of Materials Science and Engineering, National University of Singapore, Singapore, Singapore. lohxj@imre.a-star.edu.sg., Su X; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. xysu@imcb.a-star.edu.sg.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. xysu@imcb.a-star.edu.sg.; Singapore Eye Research Institute (SERI), Singapore, Singapore. xysu@imcb.a-star.edu.sg.; Department of Ophthalmology, National University Hospital, Singapore, Singapore. xysu@imcb.a-star.edu.sg.

Publikováno v: Nature communications [Nat Commun] 2022 May 19; Vol. 13 (1), pp. 2796. Date of Electronic Publication: 2022 May 19.

Multi-species single-cell transcriptomic analysis of ocular compartment regulons.

Autor: Gautam P; Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, 138673, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore., Hamashima K; Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, 138673, Singapore., Chen Y; Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, 138673, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore.; Integrative Sciences and Engineering Programme (ISEP), NUS Graduate School, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore., Zeng Y; Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, 138673, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore., Makovoz B; Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Parikh BH; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Translational Retinal Research Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, 138673, Singapore., Lee HY; Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, 138673, Singapore., Lau KA; Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, 138673, Singapore., Su X; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Translational Retinal Research Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, 138673, Singapore.; Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore, 168751, Singapore., Wong RCB; Centre for Eye Research Australia, Melbourne, Vic, Australia.; Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Vic, Australia.; Shenzhen Eye Hospital, Shenzhen University School of Medicine, Shenzhen, China., Chan WK; Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore.; Integrative Sciences and Engineering Programme (ISEP), NUS Graduate School, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore., Li H; Center for Individualized Medicine, Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA. Li.Hu@mayo.edu., Blenkinsop TA; Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. timothy.blenkinsop@mssm.edu., Loh YH; Cell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, 138673, Singapore. yhloh@imcb.a-star.edu.sg.; Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore. yhloh@imcb.a-star.edu.sg.; Integrative Sciences and Engineering Programme (ISEP), NUS Graduate School, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore. yhloh@imcb.a-star.edu.sg.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117593, Singapore. yhloh@imcb.a-star.edu.sg.

Publikováno v: Nature communications [Nat Commun] 2021 Sep 28; Vol. 12 (1), pp. 5675. Date of Electronic Publication: 2021 Sep 28.

Surgical Transplantation of Human RPE Stem Cell-Derived RPE Monolayers into Non-Human Primates with Immunosuppression.

Autor: Liu Z; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A(∗)STAR), Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore Eye Research Institute (SERI), Singapore, Singapore., Parikh BH; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A(∗)STAR), Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan QSW; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A(∗)STAR), Singapore, Singapore., Wong DSL; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ong KH; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A(∗)STAR), Singapore, Singapore., Yu W; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A(∗)STAR), Singapore, Singapore., Seah I; Department of Ophthalmology, National University Hospital, Singapore, Singapore., Holder GE; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Ophthalmology, National University Hospital, Singapore, Singapore; UCL Institute of Ophthalmology, London, UK., Hunziker W; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A(∗)STAR), Singapore, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan GSW; Singapore Eye Research Institute (SERI), Singapore, Singapore; Academic Clinical Program in Ophthalmology, Duke-NUS Medical School, Singapore, Singapore., Barathi VA; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore Eye Research Institute (SERI), Singapore, Singapore; Academic Clinical Program in Ophthalmology, Duke-NUS Medical School, Singapore, Singapore., Lingam G; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore Eye Research Institute (SERI), Singapore, Singapore; Department of Ophthalmology, National University Hospital, Singapore, Singapore., Stanzel BV; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Macula Center Saar, Eye Clinic Sulzbach, Knappschaft Hospital Saar, Sulzbach, Saar, Germany. Electronic address: boris.stanzel@kksaar.de., Blenkinsop TA; Department of Cellular, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: timothy.blenkinsop@mssm.edu., Su X; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A(∗)STAR), Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore Eye Research Institute (SERI), Singapore, Singapore; Department of Ophthalmology, National University Hospital, Singapore, Singapore. Electronic address: xysu@imcb.a-star.edu.sg.

Publikováno v: Stem cell reports [Stem Cell Reports] 2021 Feb 09; Vol. 16 (2), pp. 237-251. Date of Electronic Publication: 2021 Jan 14.

Epigenomic and Transcriptomic Changes During Human RPE EMT in a Stem Cell Model of Epiretinal Membrane Pathogenesis and Prevention by Nicotinamide.

Autor: Boles NC; Neural Stem Cell Institute, Rensselaer NY 12144, USA., Fernandes M; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Swigut T; Department of Chemical and Systems Biology, Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA., Srinivasan R; Department of Chemical and Systems Biology, Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA., Schiff L; Neural Stem Cell Institute, Rensselaer NY 12144, USA., Rada-Iglesias A; University of Cologne, Cologne 50931, Germany., Wang Q; Stony Brook University School of Medicine, Stony Brook, NY 11794, USA., Saini JS; Neural Stem Cell Institute, Rensselaer NY 12144, USA., Kiehl T; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Stern JH; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Wysocka J; Department of Chemical and Systems Biology, Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford, CA 94305, USA., Blenkinsop TA; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: timothy.blenkinsop@mssm.edu., Temple S; Neural Stem Cell Institute, Rensselaer NY 12144, USA. Electronic address: sallytemple@neuralsci.org.

Publikováno v: Stem cell reports [Stem Cell Reports] 2020 Apr 14; Vol. 14 (4), pp. 631-647. Date of Electronic Publication: 2020 Apr 02.