Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.

Autor: Roecker AJ; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Schirripa KM; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Loughran HM; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Tong L; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Liang T; Discovery Process Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Fillgrove KL; ADME & Discovery Toxicology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kuo Y; ADME & Discovery Toxicology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Bleasby K; ADME Transporters, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Collier H; ADME Transporters, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Altman MD; Computational and Structural Chemistry, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Ford MC; Computational and Structural Chemistry, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Drolet RE; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Cosden M; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Jinn S; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Hatcher NG; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Yao L; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kandebo M; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Vardigan JD; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Flick RB; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Liu X; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Minnick C; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Price LA; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Watt ML; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Lemaire W; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Burlein C; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Adam GC; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Austin LA; Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Marcus JN; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Smith SM; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Fraley ME; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Jan 12; Vol. 14 (2), pp. 146-155. Date of Electronic Publication: 2023 Jan 12 (Print Publication: 2023).

Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition.

Autor: Bleasby, K.¹ (AUTHOR) kelly_bleasby@merck.com, Castle, J. C.^1,2 (AUTHOR), Roberts, C. J.³ (AUTHOR), Cheng, C.² (AUTHOR), Bailey, W. J.⁴ (AUTHOR), Sina, J. F.⁴ (AUTHOR), Kulkarni, A. V.² (AUTHOR), Hafey, M. J.¹ (AUTHOR), Evers, R.¹ (AUTHOR), Johnson, J. M.² (AUTHOR), Ulrich, R. G.³ (AUTHOR), Slatter, J. G.³ (AUTHOR)

Publikováno v: Xenobiotica. Oct/Nov2006, Vol. 36 Issue 10/11, p963-988. 26p.

Abstract Supplement HIV Glasgow 10–13 November 2024, Glasgow, UK/Virtual.

Publikováno v: Journal of the International AIDS Society. Nov2024 Supplement 1, Vol. 27, p1-353. 353p.

Targeting Lipid Metabolism in Cancer Stem Cells for Anticancer Treatment.

Autor: Singh, Manish Kumar^1,2 (AUTHOR) manishbiochem@gmail.com, Han, Sunhee^1,2,3 (AUTHOR) sunheehan@khu.ac.kr, Kim, Sungsoo^1,2,3 (AUTHOR) sgskim@khu.ac.kr, Kang, Insug^1,2,3 (AUTHOR) sgskim@khu.ac.kr

Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 20, p11185. 28p.

Innovative Approaches to Optimize Clinical Transporter Drug–Drug Interaction Studies.

Autor: Paglialunga, Sabina¹ (AUTHOR), Benrimoh, Natacha² (AUTHOR), van Haarst, Aernout³ (AUTHOR) aernout.vanhaarst@celerion.com

Publikováno v: Pharmaceutics. Aug2024, Vol. 16 Issue 8, p992. 12p.