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of 8
pro vyhledávání: '"Blaze M. Pharoah"'
Autor:
Blaze M. Pharoah, Chengximeng Zhang, Vinayak S. Khodade, Gizem Keceli, Christopher McGinity, Nazareno Paolocci, John P. Toscano
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102625- (2023)
Cardiotoxicity is a frequent and often lethal complication of doxorubicin (DOX)-based chemotherapy. Here, we report that hydropersulfides (RSSH) are the most effective reactive sulfur species in conferring protection against DOX-induced toxicity in H
Externí odkaz:
https://doaj.org/article/37291bc455d8420fa8ab9f4557bda364
Autor:
Blaze M. Pharoah, Vinayak S. Khodade, Alexander Eremiev, Eric Bao, Ting Liu, Brian O’Rourke, Nazareno Paolocci, John P. Toscano
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 1010 (2022)
Hydrogen sulfide (H2S) exhibits protective effects in cardiovascular disease such as myocardial ischemia/reperfusion (I/R) injury, cardiac hypertrophy, and atherosclerosis. Despite these findings, its mechanism of action remains elusive. Recent studi
Externí odkaz:
https://doaj.org/article/10014171267e4bdd82252d4cf80ded26
Autor:
Gizem Keceli, Seungho Jun, Blaze M. Pharoah, Ryla Pasaoa, Reyhan M. Westbrook, Peter M. Abadir, Nazareno Paolocci
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Chemical Science
The recent discovery of the prevalence of hydropersulfides (RSSH) species in biological systems suggests their potential roles in cell regulatory processes. However, the reactive and transient nature of RSSH makes their study difficult, and dependent
Publikováno v:
Journal of the American Chemical Society. 142:4309-4316
The recent discovery of hydropersulfides (RSSH) in mammalian systems suggests their potential roles in cell signaling. However, the exploration of RSSH biological significance is challenging due to their instability under physiological conditions. He
Autor:
Christopher N. Boddy, Christina Moi, Daniel I. Pau, Blaze M. Pharoah, Amanda L. Whiting, Sterling R. Payne, Federico Bernal, Ye Joon Kim
Publikováno v:
Cell Chemical Biology. 25:1059-1066.e4
In response to environmental and other stresses, the σ(54) subunit of bacterial RNA polymerase (RNAP) controls expression of several genes which play a significant role in the virulence of both plant and animal pathogens. Recruitment of σ(54) to RN
Publikováno v:
Free Radical Biology and Medicine. 112:30
Hydrogen sulfide (H2S) is a biologically important signaling molecule that exerts diverse roles in various physiological processes. However, recent reports indicate that much of the biological activities associated with H2S may be attributed to hydro
Autor:
Ryan E. Cowley, Charles N. Fennie, Blaze M. Pharoah, Brian L. Edelbach, Sarina M. Bellows, Patrick L. Holland, Peter R. Thayer
Publikováno v:
Synthesis. 44:3595-3597
A simple two-step synthetic route leads to 2,4,6-tris(trifluoromethyl)aniline. It proceeds through deprotonation and iodination of 1,3,5-tris(trifluoromethyl)benzene, followed by copper-catalyzed amination.