Triazole GHS-R1a antagonists JMV4208 and JMV3002 attenuate food intake, body weight, and adipose tissue mass in mice

Autor: fehrentz, jean-alain, Holubova, M., Nagelová, V., Lacinova, Z., Haluzik, M., Sýkora, D., Moulin, A., Blayo, A.L., Fehrentz, J.A., Martinez, J., Stofkova, A., Jurčovičová, J., Železná, B., Maletinska, L.

Publikováno v: Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2014, 393 (1-2), pp.120-128. ⟨10.1016/j.mce.2014.06.003⟩

The only peripherally released orexigenic hormone, ghrelin, plays a key role in food intake and body weight regulation. Antagonizing the ghrelin receptor, GHS-R1a, represents a promising approach for anti-obesity therapy. In our study, two novel GHS-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024f47d8d6af3a5030db7b76f925c9a5
https://hal.archives-ouvertes.fr/hal-02871931