Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Blanton S Tolbert"'
Autor:
Prasanna Bhat, Vasilisa Aksenova, Matthew Gazzara, Emily A. Rex, Sadaf Aslam, Christina Haddad, Shengyan Gao, Matthew Esparza, Tolga Cagatay, Kimberly Batten, Sara S. El Zahed, Alexei Arnaoutov, Hualin Zhong, Jerry W. Shay, Blanton S. Tolbert, Mary Dasso, Kristen W. Lynch, Adolfo García-Sastre, Beatriz M. A. Fontoura
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Nuclear export of influenza A virus (IAV) mRNAs occurs through the nuclear pore complex (NPC). Using the Auxin-Induced Degron (AID) system to rapidly degrade proteins, we show that among the nucleoporins localized at the nucleoplasmic side o
Externí odkaz:
https://doaj.org/article/ef526c85c77e4e78867cbdc75323343a
Autor:
Sudeshi M. Abedeera, Jesse Davila-Calderon, Christina Haddad, Barrington Henry, Josephine King, Srinivasa Penumutchu, Blanton S. Tolbert
Publikováno v:
Viruses, Vol 16, Iss 1, p 75 (2023)
Viruses pose a great threat to people’s lives. Enterovirus A71 (EV-A71) infects children and infants all over the world with no FDA-approved treatment to date. Understanding the basic mechanisms of viral processes aids in selecting more efficient d
Externí odkaz:
https://doaj.org/article/94d8e8cf42a54042aa068509a6432260
Autor:
Jesse Davila-Calderon, Neeraj N. Patwardhan, Liang-Yuan Chiu, Andrew Sugarman, Zhengguo Cai, Srinivasa R. Penutmutchu, Mei-Ling Li, Gary Brewer, Amanda E. Hargrove, Blanton S. Tolbert
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Human enterovirus 71 (EV71) contains an internal ribosome entry site (IRES) that promotes translation of viral RNA. Here the authors show that an antiviral small molecule DMA-135 binds to the EV71 IRES RNA, inducing conformational change and stabiliz
Externí odkaz:
https://doaj.org/article/d51fcb6310e94966bfd95fb336390ef7
Publikováno v:
Journal of molecular biology. 434(18)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e9014fb98ea631a3fc1f0807a6916e
https://pubmed.ncbi.nlm.nih.gov/35988750
https://pubmed.ncbi.nlm.nih.gov/35988750
Autor:
Borwyn A. Wang, Hrishikesh M. Mehta, Srinivasa R. Penumutchu, Blanton S. Tolbert, Chonghui Cheng, Marek Kimmel, Torsten Haferlach, Jaroslaw P. Maciejewski, Seth J. Corey
Publikováno v:
Leukemia. 36:2499-2508
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8df69c9ec89f4d7eec374887ad704c15
https://doi.org/10.1038/s41375-022-01672-4
https://doi.org/10.1038/s41375-022-01672-4
Autor:
Mei-Ling Li, Jing-Yi Lin, Bo-Shiun Chen, Kuo-Feng Weng, Shin-Ru Shih, Jesse Davila Calderon, Blanton S Tolbert, Gary Brewer
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221048 (2019)
Enterovirus 71 (EV71) induces apoptosis to promote viral particle release. Earlier work showed that EV71 utilizes its 3C protease to induce apoptosis in a caspase-3-dependent pathway, though the mechanism is unknown. However, work from Vagner, Holcik
Externí odkaz:
https://doaj.org/article/28d0401486314236bb1ca9c517ed92a7
Publikováno v:
Vaccines, Vol 9, Iss 3, p 199 (2021)
Enterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth disease (HFMD) and herpangina. Moreover, EV-A71 infection can lead to neurological complications and death. Vaccination is the most efficient way to control virus infection.
Externí odkaz:
https://doaj.org/article/7144eea79b2b49138a5c61555ffcf74f
Autor:
Jesse Davila-Calderon, Mei-Ling Li, Srinivasa R. Penumutchu, Christina Haddad, Linzy Malcolm, Amanda E. Hargrove, Gary Brewer, Blanton S. Tolbert
Selective pressures on positive-strand RNA viruses provide opportunities to establish target site specificity and mechanisms of action of antivirals. Here, Enterovirus-A71 revertant viruses with resistant mutations in the SLII IRES domain (SLIIresist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bca89c75f2b70ff944a4566511788c5
https://doi.org/10.1101/2023.02.20.529064
https://doi.org/10.1101/2023.02.20.529064
Publikováno v:
Methods in Molecular Biology ISBN: 9781071626948
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fe1f6a5a841844856ed4ca4ce43eea0
https://doi.org/10.1007/978-1-0716-2695-5_16
https://doi.org/10.1007/978-1-0716-2695-5_16
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2570
RNA molecules are essential for carrying genetic information and regulating gene expression in most organisms including human pathogenic RNA and relate retro viruses. Targeting viral RNA (vRNA) structures provide broad opportunities to develop chemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd61516ce4e8e5394ea612f1b6989b56
https://pubmed.ncbi.nlm.nih.gov/36156785
https://pubmed.ncbi.nlm.nih.gov/36156785