Supplementary Figure Legends 1-5 from GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth In Vitro and In Vivo

Autor: Alwin Krämer, Mads H. Clausen, Kenneth C. Anderson, Hartmut Goldschmidt, Anthony D. Ho, Uwe Haberkorn, Walter Mier, Felix Nissen, Johannes Fruehauf, Klaus Podar, Patrick J. Hayden, Gleb Konotop, Ludmila Weiz, Thomas O. Larsen, Blanka Leber, Mads H. Rønnest, Simon Anderhub, Iris Breitkreutz, Marc S. Raab

PDF file - 50K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cf696053a57476d78e93663c46f604
https://doi.org/10.1158/0008-5472.22394573.v1

Supplementary Figure 5 from GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth In Vitro and In Vivo

Autor: Alwin Krämer, Mads H. Clausen, Kenneth C. Anderson, Hartmut Goldschmidt, Anthony D. Ho, Uwe Haberkorn, Walter Mier, Felix Nissen, Johannes Fruehauf, Klaus Podar, Patrick J. Hayden, Gleb Konotop, Ludmila Weiz, Thomas O. Larsen, Blanka Leber, Mads H. Rønnest, Simon Anderhub, Iris Breitkreutz, Marc S. Raab

PDF file - 51K, GF-15 significantly increases the mitotic index in MM xenograft tumors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7a8eb4d7bdb6a2e31068c72fbbec65
https://doi.org/10.1158/0008-5472.22394576.v1

Supplementary Figure 1 from GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth In Vitro and In Vivo

Autor: Alwin Krämer, Mads H. Clausen, Kenneth C. Anderson, Hartmut Goldschmidt, Anthony D. Ho, Uwe Haberkorn, Walter Mier, Felix Nissen, Johannes Fruehauf, Klaus Podar, Patrick J. Hayden, Gleb Konotop, Ludmila Weiz, Thomas O. Larsen, Blanka Leber, Mads H. Rønnest, Simon Anderhub, Iris Breitkreutz, Marc S. Raab

PDF file - 60K, GF-15 does not induce spindle multipolarity in resistant cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317a616a185e32d4f48c6dde11943300
https://doi.org/10.1158/0008-5472.22394588.v1

(+)-Geodin from Aspergillus terreus

Autor: Morten Thrane Nielsen, Thomas Ostenfeld Larsen, Mads Hartvig Clausen, Blanka Leber, Mads Holger Rønnest, Uffe Hasbro Mortensen, Alwin Krämer, Pernille Harris

Publikováno v: Rønnest, M H, Nielsen, M T, Leber, B, Mortensen, U H, Krämer, A, Clausen, M H, Larsen, T O & Harris, P 2011, ' (+)-Geodin from Aspergillus terreus. ', Acta Crystallographica. Section C: Crystal Structure Communications, vol. 67, no. Pt 3, pp. o125-o128 . https://doi.org/10.1107/S0108270111005816

The fungal metabolite (+)-geodin [systematic name: (2R)-methyl 5,7-dichloro-4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxospiro[benzofuran-2,1'-cyclohexa-2',5'-diene]-2'-carboxylate], C(17)H(12)Cl(2)O(7), was isolated from Aspergillus terreus. The crystal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498f01bcf722b896def51bc66a9a3476
https://pubmed.ncbi.nlm.nih.gov/21368412

Abstract 660: Inhibition of centrosomal clustering suppresses tumor growth in vivo

Autor: Felix Nissen, Klaus Podar, Alwin Kraemer, Mads H. Cllausen, Walter Mier, Kenneth C. Anderson, Blanka Leber, Anthony D. Ho, Johannes Fruehauf, Hartmut Goldschmidt, Iris Breitkreutz, Uwe Haberkorn, Marc S. Raab, Ludmila Weitz, Patrick Hayden, Thomas Ostenfeld Larsen

Publikováno v: Cancer Research. 71:660-660

Tumor cells frequently contain multiple centrosomes, associated with the formation of multipolar mitotic spindles and chromosome segregation defects. To allow for bipolar mitotic division, supernumerary centrosomes are clustered into two functional s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be058d661d4bbd034281a460f166ec8b
https://doi.org/10.1158/1538-7445.am2011-660