Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Blanka Klepetarova"'
Autor:
Tomáš David, Miroslava Šedinová, Aneta Myšková, Jaroslav Kuneš, Lenka Maletínská, Radek Pohl, Martin Dračínský, Helena Mertlíková-Kaiserová, Karel Čížek, Blanka Klepetářová, Miroslava Litecká, Antonín Kaňa, David Sýkora, Adam Jaroš, Michal Straka, Miloslav Polasek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Coordination compounds of lanthanides are indispensable in biomedical applications as MRI contrast agents and radiotherapeutics. However, since the introduction of the chelator DOTA four decades ago, there has been only limited progress on i
Externí odkaz:
https://doaj.org/article/9f1742eaa53148b680d760f9ec59e3ba
Autor:
Luca Julianna Tóth, Kateřina Krejčová, Milan Dejmek, Eva Žilecká, Blanka Klepetářová, Lenka Poštová Slavětínská, Evžen Bouřa, Radim Nencka
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1029-1036 (2024)
The RNA-dependent RNA polymerase (RdRp) represents a prominent target in the discovery and development of new antivirotics against RNA viruses, inhibiting the replication process. One of the most targeted RNA viruses of the last years is, without dou
Externí odkaz:
https://doaj.org/article/236a37cebaa444598c76d0293aeebeff
Publikováno v:
ACS Omega, Vol 3, Iss 4, Pp 4674-4678 (2018)
Externí odkaz:
https://doaj.org/article/14e97ecdd167472e84dbd31d8a6a7255
Autor:
Alzbeta Stefela, Miroslav Kaspar, Martin Drastik, Thales Kronenberger, Stanislav Micuda, Martin Dracinsky, Blanka Klepetarova, Eva Kudova, Petr Pavek
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Bile acids (BAs) are key signaling steroidal molecules that regulate glucose, lipid, and energy homeostasis via interactions with the farnesoid X receptor (FXR) and G-protein bile acid receptor 1 (GPBAR1). Extensive medicinal chemistry modifications
Externí odkaz:
https://doaj.org/article/41d6b0e2df9d4724951d8ee7df1dc6a6
High-valent Cu(III) trifluoromethyl complexes with 1,3-diketonates as bidentate oxygen donor ligands LCuIII(CF3)2 were prepared for the first time and fully characterized, including X-ray crystallography. These complexes are soluble in most organic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b827b7ca18106a534ce4536ab5c8c2d2
https://doi.org/10.26434/chemrxiv-2023-mlqb2
https://doi.org/10.26434/chemrxiv-2023-mlqb2
Publikováno v:
The Journal of Organic Chemistry. 75:442-449
An efficient and practical methodology of preparation of 6-substituted pyridin-2-yl C-ribonucleosides was developed. A one-pot two-step addition of 2-lithio-6-bromopyridine to TBS-protected ribonolactone followed by acetylation gave 1beta-(6-bromopyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0522b3c5c35cbf7a76d698537d7902
https://doi.org/10.1021/jo902313g
https://doi.org/10.1021/jo902313g
Publikováno v:
The Journal of Organic Chemistry. 73:9048-9054
Novel practical methodology of synthesis of a several types of di-, tri-, and tetraarylpurine derivatives by a combination of regioselective Suzuki cross-coupling reactions and/or Cu-catalyzed N-arylation with direct C-H arylations was developed. 6,8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c061be4c1faecdb33aecb6d78a5910
https://doi.org/10.1021/jo8018126
https://doi.org/10.1021/jo8018126
Publikováno v:
ChemInform. 46
Selective monoarylation at position 5 of substrate (I) becomes possible with Suzuki [-< conditions A)] or Stille coupling [-< conditions C), product (VIII)].
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2278d66847fb82d906f56381b4520677
https://doi.org/10.1002/chin.201516252
https://doi.org/10.1002/chin.201516252
Autor:
Radek Pohl, Ivana Cisarova, Denisa Hidasová, František Kafka, Martin Holan, Ullrich Jahn, Blanka Klepetarova
Publikováno v:
ChemInform. 46
Catalytic aza-Michael and Michael addition reactions/radical cyclizations/oxygenation reactions which incorporate the N-oxopiperidinium oxidant (III) as a functionality into the products are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::258a49eaed436dcb92d54294ac275906
https://doi.org/10.1002/chin.201509199
https://doi.org/10.1002/chin.201509199
Publikováno v:
European Journal of Organic Chemistry. 2005:4525-4528
A novel efficient and practical approach to the synthesis of 4- or 3-substituted phenyl C-nucleosides has been developed. It consists in coupling of protected halogenose 1 with bromophenylmagnesium bromides followed by acid mediated epimerization to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0626197294549ab25a0f07f19b28ba63
https://doi.org/10.1002/ejoc.200500607
https://doi.org/10.1002/ejoc.200500607