Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Blanka Binkova"'
Autor:
Jiří Nožička, Miroslav Dostal, Blanka Binkova, František Kotěšovec, Alena Milcova, Radim J. Sram, Jan Topinka
Publikováno v:
International Journal of Hygiene and Environmental Health. 211:318-325
In the course of epidemiologic studies on the health of preschool children in the Teplice and Prachatice districts of the Czech Republic, we have recorded the frequency of smokers in the families of the children under study and the exposure of the ch
Autor:
Blanka Binkova, Ivo Solansky, Radim J. Sram, Irena Chvatalova, Zdena Lnenickova, O. Sevastyanova, Zuzana Novakova, Jan Topinka, Alena Milcova
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 624:9-17
The effect of exposure to organic compounds adsorbed onto respirable air particles (2.5microm) on DNA adducts in lymphocytes was studied in a group of non-smoking policemen (N=109, aged 35+/-0.9 years) working in the downtown area of Prague and spend
Autor:
Radim J. Sram, Blanka Binkova, Peter B. Farmer, Tzveta Georgieva, Todor A. Popov, Ivan Kalina, Rajinder Singh, Seymour Garte, Emanuela Taioli
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:83-92
Polycyclic aromatic hydrocarbons (PAHs) appear to be significant contributors to the genotoxicity and carcinogenicity of air pollution present in the urban environment for humans. Populations exposed to environmental air pollution show increased leve
Autor:
Zuzana Valovičová, Alena Gábelová, Peter B. Farmer, Gabriela Bačová, Blanka Binkova, Juraj Labaj
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:135-144
The free radical generating activity of airborne particulate matter (PM(10)) has been proposed as a primary mechanism in biological activity of ambient air pollution. In an effort to determine the impact of the complex mixtures of extractable organic
Autor:
Peter B. Farmer, Blanka Binkova, Todor A. Popov, Radim J. Sram, O. Sevastyanova, Ivan Kalina, Zuzana Novakova, Jan Topinka
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:123-134
Principal aims of this study were at first, to find a relevant human derived cell line to investigate the genotoxic potential of PAH-containing complex mixtures and second, to use this cell system for the analysis of DNA adduct forming activity of or
Autor:
Pavel Rossner, Radim J. Sram, Alena Milcova, Zdena Lnenickova, Olena Beskid, Andrea Rossnerova, Ivo Solansky, Blanka Binkova
Publikováno v:
Toxicology Letters. 172:12-20
The capital city of Prague is one of the most polluted localities of the Czech Republic. The effect of exposure to carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) adsorbed onto respirable air particles (2.5 microm) on chromosomal aberrations w
Autor:
Rajinder Singh, Radim J. Sram, K. Lyubomirova, Emanuela Taioli, Blanka Binkova, Seymour Garte, Sara Raimondi, Ivan Kalina, Peter B. Farmer
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:93-102
Modification of DNA is believed to be a key step in carcinogenesis, and therefore DNA adducts have been proposed as predictive biomarkers of human cancer. Smoked and grilled foods are important contributors of PAH-DNA adduct levels, while the consump
Autor:
Pb B. Farmer, Jana Schmuczerova, Todor A. Popov, O. Sevastyanova, Ivan Kalina, Rj J. Sram, Jan Topinka, Blanka Binkova, Zuzana Novakova
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:114-122
Acellular assay of calf thymus DNA+/-rat liver microsomal S9 fraction coupled with (32)P-postlabelling was used to study the genotoxic potential of organic compounds bound onto PM10 particles collected in three European cities-Prague (CZ), Kosice (SK
Autor:
Antonina Cebulska-Wasilewska, Peter B. Farmer, Ivan Kalina, Blanka Binkova, Radim J. Sram, Teodor Popov
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:155-164
Previous results from studies performed in three European cities suggested a decrease in DNA repair efficiency observed in lymphocytes of subjects occupationally exposed to environmental carcinogenic polycyclic aromatic hydrocarbons (c-PAHs). The aim
Autor:
Peter B. Farmer, Valentina Paracchini, Emanuela Taioli, Rajinder Singh, Todor A. Popov, Ivan Kalina, Blanka Binkova, Radim J. Sram, Seymour Garte, Sara Raimondi
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:7-15
Data from the EXPAH project on PAH exposure and intermediary biomarkers were analyzed with respect to individual genotypes at seven metabolic gene loci. The GSTM1 null allele was associated with significantly higher levels of two biomarkers, malondia