Data from Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation

Autor: Nathalie Andrieu-Abadie, Thierry Levade, Patrice Codogno, Chantal Bauvy, Mojgan Djavaheri-Mergny, Virginie Garcia, Sonia-Caroline Sorli, Virginie Albinet, Carmen Bedia, Blandine Kedjouar, Paul P. Van Veldhoven, Sandra Colié

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in cancer development through stimulation of cell survival, proliferation, migration, and angiogenesis. Irreversible degradation of S1P is catalyzed by S1P lyase (SPL). The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a4614473e780b67fbe0ccfeacac719d
https://doi.org/10.1158/0008-5472.c.6500387

Stat3 controls lysosomal-mediated cell death in vivo

Autor: Anna Staniszewska, Nader Omidvar, Wenjing Li, James Turkson, Richard W. E. Clarkson, Richard A. Flavell, Valeria Poli, Peter A. Kreuzaler, Blandine Kedjouar, Christine J. Watson

Publikováno v: Nature Cell Biology. 13:303-309

It is well established that lysosomes play an active role during the execution of cell death1. A range of stimuli can lead to lysosomal membrane permeabilization (LMP), thus inducing programmed cell death without involvement of the classical apoptoti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5088cc4f78253b465816cfbd52c478a8
https://doi.org/10.1038/ncb2171

IKKβ/2 induces TWEAK and apoptosis in mammary epithelial cells

Autor: Marion Huth, Fiona O. Baxter, Kathrine Abell, Paul J. Came, Blandine Kedjouar, Manolis Pasparakis, Christine J. Watson, Klaus Rajewsky

Publikováno v: Development. 133:3485-3494

The Nuclear Factor-kappaB (NF-kappaB) family of transcription factors are ubiquitously expressed and control a wide range of cellular responses, including apoptosis, proliferation, differentiation, inflammation and immunity. Here, we investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b8c3b1ef7996ce5fd9e6f949987242
https://doi.org/10.1242/dev.02502

Molecular characterization of the microsomal tamoxifen binding site

Autor: Moustapha Oulad-Abdelghani, Blandine Kedjouar, Marc Poirot, Philippe de Medina, Gilles Favre, Jean-Charles Faye, Bruno Payré, Sandrine Silvente-Poirot

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2004, 279, pp.34048-61. ⟨10.1074/jbc.M405230200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279, pp.34048-61. ⟨10.1074/jbc.M405230200⟩

Tamoxifen is a selective estrogen receptor modulator widely used for the prophylactic treatment of breast cancer. In addition to the estrogen receptor (ER), tamoxifen binds with high affinity to the microsomal antiestrogen binding site (AEBS), which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2b4407d159b064ab8bf1cf9284a027
https://pubmed.ncbi.nlm.nih.gov/15175332

Modifications of benzylphenoxy ethanamine antiestrogen molecules: influence affinity for antiestrogen binding site (AEBS) and cell cytotoxicity

Autor: Fabienne Mésange, Marc Poirot, Blandine Kedjouar, Francis Bayard, Frédéric Delarue, Jean-Charles Faye

Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 1999, 57, pp.657-61

The antiestrogen binding site (AEBS) is a membranous protein complex that has been shown to be intimately linked with the antiproliferative and antiretroviral effects of certain antiestrogenic compounds such as tamoxifen (Tx). Various specific ligand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98625f71f05cc3fb493cacd5f1c61426
https://www.hal.inserm.fr/inserm-00090781