An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

Autor: Blandine De La Gastine, Soizic Percevault, Laurent Varin, Nicolas Richard, Fabienne Fobe, Benoît Plaud, Georges Daccache, Vincent Compere, Jean-Jacques Parienti, Antoine Coquerel, Magalie Loilier, Nathalie Bleyzac, Laurent Bourguignon, Sylvain Goutelle, Véronique Lelong-Boulouard

Publikováno v: Pharmaceutics, Vol 14, Iss 10, p 2177 (2022)

Cytochrome P450 2D6 (CYP2D6) gene polymorphisms influence the exposure to tramadol (T) and its pharmacologically active metabolite, O-demethyl tramadol (O-dT). Tramadol has been considered as a candidate probe drug for CYP2D6 phenotyping. The objecti

Externí odkaz: https://doaj.org/article/ee290fbcb63e4bc0b0972c421252562e

Pancréatite aiguë en lien avec la migration d’une sonde de gastrostomie : à propos d’un cas et revue de la littérature

Autor: Sylvain Goutelle, Marc O’Brien, Anne-Margaux Belat, Audrey Haquin, Blandine de la Gastine

Publikováno v: La Presse Médicale. 48:563-567

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ea489d02cf65bc672575c6d666c2e82
https://doi.org/10.1016/j.lpm.2019.04.007

Prevalence and Risk Factors of Drug-Associated Corrected QT Prolongation in Elderly Hospitalized Patients: Results of a Retrospective Analysis of Data Obtained Over 6 Months

Autor: Sylvain Goutelle, Ophélie Maison, Laurent Dayot, Blandine de la Gastine

Publikováno v: Drugs & aging
Drugs & aging, 2017, 34, pp.545-553. ⟨10.1007/s40266-017-0467-5⟩

Little information exists on the frequency and determinants of drug-associated long QT syndrome in older adults. The objectives of this study were to assess the prevalence and identify risk factors of drug-associated long QT syndrome in a population

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca54232a255ffd0b97363c8b97356104
https://doi.org/10.1007/s40266-017-0467-5

Implications of using the MDRD or CKD-EPI equation instead of the Cockcroft-Gault equation for estimating renal function and drug dosage adjustment in elderly patients

Autor: Pascal Maire, Laetitia Goutelle-Audibert, Blandine de la Gastine, Elodie Cartet-Farnier, Sylvain Goutelle

Publikováno v: Fundamental & Clinical Pharmacology
Fundamental & Clinical Pharmacology, 2017, 31, pp.110-119. ⟨10.1111/fcp.12241⟩
Fundamental and Clinical Pharmacology
Fundamental and Clinical Pharmacology, Wiley, 2017, 31, pp.110-119. ⟨10.1111/fcp.12241⟩

The objectives of this study were to compare the estimations of renal function obtained with six equations, including the Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b91ed75b6120f6b82ba9cfbd26e9c4
https://hal.science/hal-02049666

L’hyponatrémie modérée potentiellement médicamenteuse du sujet âgé : bénéfice de la réduction des médicaments

Autor: Laure Peyro Saint Paul, Brigitte Mosquet, Blandine de la Gastine, Cathy Gaillard, Antoine Coquerel, Jocelyne Martin

Publikováno v: Therapies. 68:341-346

Resume Objectif Cette etude a pour but l’evaluation d’un changement medicamenteux chez le sujet âge presentant une hyponatremie moderee potentiellement iatrogene. Methode Les patients âges souffrant d’hyponatremie moderee potentiellement indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14be1a9cd2d1df3679fe53b723059d28
https://doi.org/10.2515/therapie/2013058