Inhibition of choline metabolism in an angioimmunoblastic T-cell lymphoma preclinical model reveals a new metabolic vulnerability as possible target for treatment

Autor: Adrien Krug, Marie Tosolini, Blandine Madji Hounoum, Jean-Jacques Fournié, Roger Geiger, Matteo Pecoraro, Patrick Emond, Philippe Gaulard, François Lemonnier, Jean-Ehrland Ricci, Els Verhoeyen

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)

Abstract Background Angioimmunoblastic T-cell lymphoma (AITL) is a malignancy with very poor survival outcome, in urgent need of more specific therapeutic strategies. The drivers of malignancy in this disease are CD4+ follicular helper T cells (Tfh).

Externí odkaz: https://doaj.org/article/0685f8cd030f49b99d2ba6536610e7de

Author Reply to Peer Reviews of Multiomics study of CHCHD10S59L-related disease reveals energy metabolism downregulation: OXPHOS and beta-oxidation deficiencies associated with lipids alterations

Autor: Blandine Madji Hounoum, Rachel Bellon, Emmanuelle C GENIN, Sylvie Bannwarth, Antoine Lefèvre, Lucile Fleuriol, Delphine Debayle, Anne Sophie Gay, Agnes Petit-Paitel, Sandra Lacas-Gervais, Hélène Blasco, Patrick Edmond, Veronique Paquis, Jean-Ehrland Ricci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e29b862b8652c227a1586bb6a294c1af
https://doi.org/10.15252/rc.2023541435

Putative imbalanced amino acid metabolism in rainbow trout long term fed a plant-based diet as revealed by 1 H-NMR metabolomics

Autor: Geneviève Corraze, Françoise Médale, Catherine Deborde, Blandine Madji Hounoum, Daniel J. Jacob, Annick Moing, Benoit Fauconneau, Mickaël Maucourt

Publikováno v: Journal of Nutritional Science
Journal of Nutritional Science, Nutrition Society, 2021, 10, pp.e13. ⟨10.1017/jns.2021.3⟩

The long-term effect of a plant (P)-based diet was assessed by proton nuclear magnetic resonance (1H-NMR) metabolomics in rainbow trout fed a marine fish meal (FM)–fish oil (FO) diet (M), a P-based diet and a control commercial-like diet (C) starti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fdb0db3932654b93127f6710656e11
http://hdl.handle.net/20.500.12278/110357

Workflow methodology for rat brain metabolome exploration using NMR, LC–MS and GC–MS analytical platforms

Autor: Christian R. Andres, Blandine Madji Hounoum, Lydie Nadal-Desbarats, Frédéric Montigny, Sylvie Mavel, Laurent Galineau, Binta Diémé, Antoine Lefèvre, Patrick Emond, Hélène Blasco

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2017, 142, pp.270-278. ⟨10.1016/j.jpba.2017.03.068⟩

We developed a multi-platform approach for the metabolome exploration of rat brain tissue, using liquid chromatography coupled with mass spectrometry (LC-MS), nuclear magnetic resonance spectroscopy (NMR) and gas-chromatography coupled with mass spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84179e44639313ea11d3b89c99f6fe54
https://doi.org/10.1016/j.jpba.2017.03.068

Wildtype motoneurons, ALS-Linked SOD1 mutation and glutamate profoundly modify astrocyte metabolism and lactate shuttling

Autor: Blandine Madji Hounoum, Sylviane Marouillat, Patrick Emond, Cédric Raoul, Philippe Corcia, Patrick Vourc'h, Emmanuelle Coque, Lydie Nadal-Desbarats, Franck Patin, Christian R. Andres, Hélène Blasco, Sylvie Mavel

Publikováno v: Glia. 65:592-605

The selective degeneration of motoneuron that typifies amyotrophic lateral sclerosis (ALS) implicates non-cell-autonomous effects of astrocytes. However, mechanisms underlying astrocyte-mediated neurotoxicity remain largely unknown. According to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb2ad4a45cc75a8f6b6b1458bc00717d
https://doi.org/10.1002/glia.23114