Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas.

Autor: Blanco-Carmona E; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany., Narayanan A; Neurology Clinic and National Center for Tumor Diseases, Heidelberg University Hospital and Heidelberg University, Heidelberg, Germany., Hernandez I; Next Generation Sequencing Core, Leibniz Institute for Immunotherapy, c/o University Hospital Regensburg, Regensburg, Germany; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Nieto JC; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Elosua-Bayes M; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Sun X; Neurology Clinic and National Center for Tumor Diseases, Heidelberg University Hospital and Heidelberg University, Heidelberg, Germany; DKTK CCU Neurooncology, DKFZ, Heidelberg, Germany., Schmidt C; Core Facility Unit Light Microscopy, DKFZ, Heidelberg, Germany., Pamir N; Acıbadem Mehmet Ali Aydınlar University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey., Özduman K; Acıbadem Mehmet Ali Aydınlar University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey., Herold-Mende C; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany., Pagani F; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia Medical School, Brescia, Italy., Cominelli M; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia Medical School, Brescia, Italy., Taranda J; Neurology Clinic and National Center for Tumor Diseases, Heidelberg University Hospital and Heidelberg University, Heidelberg, Germany; DKTK CCU Neurooncology, DKFZ, Heidelberg, Germany., Wick W; Neurology Clinic and National Center for Tumor Diseases, Heidelberg University Hospital and Heidelberg University, Heidelberg, Germany; DKTK CCU Neurooncology, DKFZ, Heidelberg, Germany., von Deimling A; Department of Neuropathology, Heidelberg University Hospital, and DKTK CCU Neuropathology, DKFZ, Heidelberg, Germany., Poliani PL; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia Medical School, Brescia, Italy., Rehli M; Next Generation Sequencing Core, Leibniz Institute for Immunotherapy, c/o University Hospital Regensburg, Regensburg, Germany; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Schlesner M; Biomedical Informatics, Data Mining and Data Analytics, Faculty for Applied Informatics, University of Augsburg, Augsburg, Germany., Heyn H; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: holger.heyn@cnag.eu., Turcan Ş; Neurology Clinic and National Center for Tumor Diseases, Heidelberg University Hospital and Heidelberg University, Heidelberg, Germany; DKTK CCU Neurooncology, DKFZ, Heidelberg, Germany. Electronic address: sevin.turcan@med.uni-heidelberg.de.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2023 Nov 21; Vol. 4 (11), pp. 101249. Date of Electronic Publication: 2023 Oct 25.

Comparative time-series multi-omics analyses suggest H1.2 involvement in anoxic adaptation and cancer resistance.

Autor: Du, Juan^1,2 (AUTHOR), Liu, Weiqiang^1,2 (AUTHOR), Li, Meng¹ (AUTHOR), Li, Zihao^1,2 (AUTHOR), Li, Xuanjing^1,2 (AUTHOR), Dai, Yichen¹ (AUTHOR), Liu, Gaoming¹ (AUTHOR), Wang, Xiao¹ (AUTHOR), Zhu, Pingfen¹ (AUTHOR), Gladyshev, Vadim N.³ (AUTHOR), Zhou, Xuming¹ (AUTHOR) zhouxuming@ioz.ac.cn

Publikováno v: PLoS Biology. 8/23/2024, Vol. 22 Issue 8, p1-34. 34p.

Mesenchymal ovarian cancer cells promote CD8⁺ T cell exhaustion through the LGALS3-LAG3 axis.

Autor: Yakubovich, Edward^1,2,3 (AUTHOR) eyaku027@uottawa.ca, Cook, David P.^1,2 (AUTHOR), Rodriguez, Galaxia M.^1,2,3 (AUTHOR), Vanderhyden, Barbara C.^1,2,3 (AUTHOR)

Publikováno v: NPJ Systems Biology & Applications. 12/12/2023, Vol. 9 Issue 1, p1-17. 17p.

Molecular profiles, sources and lineage restrictions of stem cells in an annelid regeneration model.

Autor: Stockinger, Alexander W., Adelmann, Leonie, Fahrenberger, Martin, Ruta, Christine, Özpolat, B. Duygu, Milivojev, Nadja, Balavoine, Guillaume, Raible, Florian

Publikováno v: Nature Communications; 11/18/2024, Vol. 15 Issue 1, p1-18, 18p

In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma.

Autor: Liu, S. John, Zou, Christopher, Pak, Joanna, Morse, Alexandra, Pang, Dillon, Casey-Clyde, Timothy, Borah, Ashir A., Wu, David, Seo, Kyounghee, O'Loughlin, Thomas, Lim, Daniel A., Ozawa, Tomoko, Berger, Mitchel S., Kamber, Roarke A., Weiss, William A., Raleigh, David R., Gilbert, Luke A.

Publikováno v: Genome Biology; 10/7/2024, Vol. 25 Issue 1, p1-32, 32p