Výsledky vyhledávání - "Blanca Torroba"

RNA-based drug discovery for spinal muscular atrophy: a story of small molecules and antisense oligonucleotides

Autor: Blanca, Torroba, Natsuko, Macabuag, Elisabeth M, Haisma, Amy, O'Neill, Maria E, Herva, Roxana S, Redis, Michael V, Templin, Lauren E, Black, David F, Fischer

Publikováno v: Expert Opinion on Drug Discovery. 18:181-192

Spinal Muscular Atrophy (SMA), the second most prevalent autosomal genetic disease affecting infants, is caused by the lack ofThis manuscript will cover two of the three mechanistically distinct available treatment options for SMA, both targeting the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba36e48f54cbb6e977d3802f85514c4b
https://doi.org/10.1080/17460441.2022.2149733

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Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity

Autor: Antonio Herrera, Andrea Ochoa, Blanca Torroba, Anghara Menendez, Sebastian Pons

Publikováno v: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
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The Journal of Cell Biology

© 2021 Herrera et al.
The neural tube forms when neural stem cells arrange into a pseudostratified, single-cell–layered epithelium, with a marked apico-basal polarity, and in which adherens junctions (AJs) concentrate in the subapical domain.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7f4e08b759b3e820b9f326089f2059
http://hdl.handle.net/10261/241513

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β-Catenin tumour-suppressor activity depends on its ability to promote Pro-N-Cadherin maturation

Autor: Sebastian Pons, Anghara Menendez, Blanca Torroba, Antonio J. Herrera

SUMMARYNeural stem cells (NSCs) form a pseudostratified, single-cell layered epithelium with a marked apico-basal polarity. In these cells, β-Catenin associates with classic cadherins in order to form the apical adherens junctions (AJs). We previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94784bc787db2d89bd31dba6a0e939f3
https://doi.org/10.1101/571810

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PI3K regulates intraepithelial cell positioning through Rho GTP-ases in the developing neural tube

Autor: Sebastian Pons, Antonio Herrera, Anghara Menendez, Blanca Torroba

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Phosphatidylinositol 3-kinases (PI3Ks) are signal transducers of many biological processes. Class 1 A PI3Ks are hetero dimers formed by a regulatory and a catalytic subunit. We have used the developing chicken neural tube (NT) to study the roles play

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5538f75a462347b86a86130aa5425a60
http://hdl.handle.net/10261/174147

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Chemical speciation of MeHg

Autor: Borja, Díaz de Greñu, José, García-Calvo, José, Cuevas, Gabriel, García-Herbosa, Begoña, García, Natalia, Busto, Saturnino, Ibeas, Tomás, Torroba, Blanca, Torroba, Antonio, Herrera, Sebastian, Pons

Publikováno v: Chemical Science

Speciation of Hg2+ and MeHg+ has been achieved by in vitro approaches with fluorogenic probes supported in cultured cells.
Selected new fluorogenic probes that interact in different ways with Hg2+ and MeHg+ have been prepared and used for the ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::baec262dc5b6791d12b9798d4b631f64
https://pubmed.ncbi.nlm.nih.gov/29218145

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MicroRNA 22 regulates cell cycle length in cerebellar granular neuron precursors

Autor: Sebastian Pons, Blanca Torroba, Laura Vuolo, Antonio Herrera, Jordi Berenguer, Lauro Sumoy, Franc Llorens

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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During cerebellum development, Sonic hedgehog (Shh)-induced proliferation of cerebellar granular neuronal precursors (CGNPs) is potently inhibited by bone morphogenetic proteins (BMPs). We have previously reported the upregulation of TIEG-1 and Mash1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2287de14de6fa068bdd0121e4043343c
http://hdl.handle.net/10261/88552

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Ciliary adenylyl cyclases control the Hedgehog pathway

Autor: Antonio Herrera, Blanca Torroba, Laura Vuolo, Anghara Menendez, Sebastian Pons

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Protein kinase A (PKA) accumulates at the base of the cilium where it negatively regulates the Hedgehog (Hh) pathway. Although PKA activity is essentially controlled by the cAMP produced by adenylyl cyclases, the influence of these enzymes on the Hh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9ad52d8ed72bc0da4106c19a5f630c
https://doi.org/10.1242/dev.128785

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