Výsledky vyhledávání - "Blanca Scheijen"

Akademický článek

Clonal Relationship and Mutation Analysis in Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia Associated With Diffuse Large B-cell Lymphoma

Autor: Madeleine R. Berendsen, Diede A.G. van Bladel, Eva Hesius, Cristina Berganza Irusquieta, Jos Rijntjes, Annemiek B. van Spriel, Ellen van der Spek, Johannes F.M. Pruijt, Leonie I. Kroeze, Konnie M. Hebeda, Sandra Croockewit, Wendy B.C. Stevens, J Han J.M. van Krieken, Patricia J.T.A. Groenen, Michiel van den Brand, Blanca Scheijen

Publikováno v: HemaSphere, Vol 7, Iss 11, p e976 (2023)

Patients with lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) occasionally develop diffuse large B-cell lymphoma (DLBCL). This mostly results from LPL/WM transformation, although clonally unrelated DLBCL can also arise. LPL/WM is c

Externí odkaz: https://doaj.org/article/b1eea56b04e64b798ef6fb53b94420e2

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Akademický článek

Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways

Autor: Miriam Butler, Britt M.T. Vervoort, Dorette S. van Ingen Schenau, Lieneke Jongeneel, Jordy C.G. van der Zwet, René Marke, Jules P.P. Meijerink, Blanca Scheijen, Laurens T. van der Meer, Frank N. van Leeuwen

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Although long-term survival in pediatric acute lymphoblastic leukemia (ALL) currently exceeds 90%, some subgroups, defined by specific genomic aberrations, respond poorly to treatment. We previously reported that leukemias harboring deletions or muta

Externí odkaz: https://doaj.org/article/bd62010cd4ac4cb38d96197bfa9e66ae

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Akademický článek

Identification of novel GNAS mutations in intramuscular myxoma using next-generation sequencing with single-molecule tagged molecular inversion probes

Autor: Elise M. Bekers, Astrid Eijkelenboom, Paul Rombout, Peter van Zwam, Suzanne Mol, Emiel Ruijter, Blanca Scheijen, Uta Flucke

Publikováno v: Diagnostic Pathology, Vol 14, Iss 1, Pp 1-10 (2019)

Abstract Background Intramuscular myxoma (IM) is a hypocellular benign soft tissue neoplasm characterized by abundant myxoid stroma and occasional hypercellular areas. These tumors can, especially on biopsy material, be difficult to distinguish from

Externí odkaz: https://doaj.org/article/07f88e3c24484780a47a1c2e67e4dd72

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Akademický článek

The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia

Autor: René Marke, Frank N. van Leeuwen, Blanca Scheijen

Publikováno v: Haematologica, Vol 103, Iss 4 (2018)

Transcription factor IKZF1 (IKAROS) acts as a critical regulator of lymphoid differentiation and is frequently deleted or mutated in B-cell precursor acute lymphoblastic leukemia. IKZF1 gene defects are associated with inferior treatment outcome in b

Externí odkaz: https://doaj.org/article/b8dae7a6aba149109f3f60a37a35a6a0

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Akademický článek

Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients

Autor: Blanca Scheijen, Judith M. Boer, René Marke, Esther Tijchon, Dorette van Ingen Schenau, Esmé Waanders, Liesbeth van Emst, Laurens T. van der Meer, Rob Pieters, Gabriele Escherich, Martin A. Horstmann, Edwin Sonneveld, Nicola Venn, Rosemary Sutton, Luciano Dalla-Pozza, Roland P. Kuiper, Peter M. Hoogerbrugge, Monique L. den Boer, Frank N. van Leeuwen

Publikováno v: Haematologica, Vol 102, Iss 3 (2017)

Deletions and mutations affecting lymphoid transcription factor IKZF1 (IKAROS) are associated with an increased relapse risk and poor outcome in B-cell precursor acute lymphoblastic leukemia. However, additional genetic events may either enhance or n

Externí odkaz: https://doaj.org/article/4b9e33dbdf0346af888f8b42df273b6a

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Akademický článek

Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton.

Autor: Esther Tijchon, Dorette van Ingen Schenau, Fred van Opzeeland, Felice Tirone, Peter M Hoogerbrugge, Frank N Van Leeuwen, Blanca Scheijen

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0131481 (2015)

Btg1 and Btg2 encode highly homologous proteins that are broadly expressed in different cell lineages, and have been implicated in different types of cancer. Btg1 and Btg2 have been shown to modulate the function of different transcriptional regulato

Externí odkaz: https://doaj.org/article/99908c2bce9342849a4752f2671e8943

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Akademický článek

The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution.

Autor: Esmé Waanders, Blanca Scheijen, Laurens T van der Meer, Simon V van Reijmersdal, Liesbeth van Emst, Yvet Kroeze, Edwin Sonneveld, Peter M Hoogerbrugge, Ad Geurts van Kessel, Frank N van Leeuwen, Roland P Kuiper

Publikováno v: PLoS Genetics, Vol 8, Iss 2, p e1002533 (2012)

Recurrent submicroscopic deletions in genes affecting key cellular pathways are a hallmark of pediatric acute lymphoblastic leukemia (ALL). To gain more insight into the mechanism underlying these deletions, we have studied the occurrence and nature

Externí odkaz: https://doaj.org/article/e9d7e52f51aa42f59b59e9ea3e9b9e39

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Detection of Second Primary Lymphoma in Late Diffuse Large B-cell Lymphoma Recurrences

Publikováno v: Modern Pathology, 36
Modern Pathology, 36(5). ELSEVIER SCIENCE INC
Modern Pathology, 36, 5

Approximately one-third of patients with diffuse large B-cell lymphoma (DLBCL) relapse and often require salvage chemotherapy followed by autologous stem cell transplantation. In most cases, the clonal relationship between the first diagnosis and sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db5e019cdc1fa5d0040d95489fd768a
https://hdl.handle.net/2066/291853

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