Preserved blood-brain barrier and neurovascular coupling in female 5xFAD model of Alzheimer’s disease

Autor: Oleg Zhukov, Chen He, Rana Soylu-Kucharz, Changsi Cai, Andreas D. Lauritzen, Blanca Irene Aldana, Maria Björkqvist, Martin Lauritzen, Krzysztof Kucharz

Publikováno v: Frontiers in Aging Neuroscience, Vol 15 (2023)

IntroductionDysfunction of the cerebral vasculature is considered one of the key components of Alzheimer’s disease (AD), but the mechanisms affecting individual brain vessels are poorly understood.MethodsHere, using in vivo two-photon microscopy in

Externí odkaz: https://doaj.org/article/b3fa1bc5def64695840bbc4a5b1b8b6e

Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus

Autor: Theresa S. Rimmele, Shaomin Li, Jens Velde Andersen, Emil W. Westi, Alexander Rotenberg, Jianlin Wang, Blanca Irene Aldana, Dennis J. Selkoe, Chiye J. Aoki, Chris G. Dulla, Paul Allen Rosenberg

Publikováno v: Frontiers in Cellular Neuroscience, Vol 15 (2021)

GLT-1, the major glutamate transporter in the mammalian central nervous system, is expressed in presynaptic terminals that use glutamate as a neurotransmitter, in addition to astrocytes. It is widely assumed that glutamate homeostasis is regulated pr

Externí odkaz: https://doaj.org/article/bd922351081f490ab166d4b63a3be5b0

Corrigendum to 'Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line' [Stem Cell Res. 34/1873–5061 (2019) 101349–55]

Autor: Benjamin Schmid, Kennie R. Prehn, Natakarn Nimsanor, Blanca Irene Aldana Garcia, Ulla Poulsen, Ida Jørring, Mikkel A. Rasmussen, Christian Clausen, Ulrike A. Mau-Holzmann, Sarayu Ramakrishna, Ravi Muddashetty, Rachel Steeg, Kevin Bruce, Peter Mackintosh, Andreas Ebneth, Bjørn Holst, Alfredo Cabrera-Socorro

Publikováno v: Stem Cell Research, Vol 48, Iss , Pp 102005- (2020)

Externí odkaz: https://doaj.org/article/f3aa73823c6e40efaa11c1b63aeb5f6c

Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood–Brain Barrier Adherence, Uptake, and Permeation

Autor: Mie Kristensen, Krzysztof Kucharz, Eduardo Felipe Alves Fernandes, Kristian Strømgaard, Morten Schallburg Nielsen, Hans Christian Cederberg Helms, Anders Bach, Malte Ulrikkaholm Tofte-Hansen, Blanca Irene Aldana Garcia, Martin Lauritzen, Birger Brodin

Publikováno v: Pharmaceutics, Vol 12, Iss 7, p 661 (2020)

Novel stroke therapies are needed. Inhibition of the interaction between the postsynaptic density-95 (PSD-95)/disc large/ZO-1 (PDZ) domains of PSD-95 and the N-methyl-D-aspartate (NMDA) receptor has been suggested as a strategy for relieving neuronal

Externí odkaz: https://doaj.org/article/d683f301943540a996288fab6024152a

Proteomic phenotype of cerebral organoids derived from autism spectrum disorder patients reveal disrupted energy metabolism, cellular components, and biological processes

Autor: Mirolyuba Ilieva, Blanca Irene Aldana, Kasper Tore Vinten, Sonja Hohmann, Thomas William Woofenden, Renate Lukjanska, Helle S. Waagepetersen, Tanja Maria Michel

Publikováno v: Ilieva, M, Aldana, B I, Vinten, K T, Hohmann, S, Woofenden, T W, Lukjanska, R, Waagepetersen, H S & Michel, T M 2022, ' Proteomic phenotype of cerebral organoids derived from autism spectrum disorder patients reveal disrupted energy metabolism, cellular components, and biological processes ', Molecular Psychiatry, vol. 27, no. 9, pp. 3749-3759 . https://doi.org/10.1038/s41380-022-01627-2

The way in which brain morphology and proteome are remodeled during embryonal development, and how they are linked to the cellular metabolism, could be a key for elucidating the pathological mechanisms of certain neurodevelopmental disorders. Cerebra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac486c3bde354908bdbe339d2a7246f
https://vbn.aau.dk/da/publications/2f5bb111-5940-4e74-83e9-8f73c0bb8360