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Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells

Autor: F. Aragón, Blanca Rubi, Rafael Maldonado, Anna Novials, Melis Karaca, Pierre Maechler

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
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Biochimica et biophysica acta
Biochimica et Biophysica Acta, Vol. 1850, No 2 (2015) pp. 343-51

BACKGROUND: Plasma levels of pancreatic polypeptide (PP) rise upon food intake. Although other pancreatic islet hormones, such as insulin and glucagon, have been extensively investigated, PP secretion and actions are still poorly understood. METHODS:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2786d080fbb98730f10b3a45c272e686
https://doi.org/10.1016/j.bbagen.2014.11.005

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Deletion of Glutamate Dehydrogenase in ß-Cells Abolishes Part of the Insulin Secretory Response Not Required for Glucose Homeostasis

Autor: Stefania Carobbio, Asllan Gjinovci, Laurene Marine Vetterli, Maria Bloksgaard, Francesca Frigerio, Blanca Rubi, Shirin Pournourmohammadi, Walter Reith, Pierre Maechler, Pedro Luis Herrera, Susanne Mandrup

Publikováno v: Journal of Biological Chemistry, Vol. 284, No 2 (2009) pp. 921-929
Carobbio, S, Frigerio, F, Rubi, B, Vetterli, L, Mølgaard, M B, Gjinovci, A, Pournourmohammad, S, Herrera, P L, Reith, W, Mandrup, S & Maechler, P 2009, ' Deletion of Glutamate Dehydrogenase in ß-Cells Abolishes Part of the Insulin Secretory Response Not Required for Glucose Homeostasis ', Journal of Biological Chemistry, vol. 284, no. 2, pp. 921-929 . https://doi.org/10.1074/jbc.M806295200

Udgivelsesdato: 2009-Jan-9 Insulin exocytosis is regulated in pancreatic ss-cells by a cascade of intracellular signals translating glucose levels into corresponding secretory responses. The mitochondrial enzyme glutamate dehydrogenase (GDH) is regar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a781c6b0872609f0b079b477bd4c00
https://doi.org/10.1074/jbc.m806295200

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Diabetes-associated mitochondrial DNA mutation A3243G impairs cellular metabolic pathways necessary for beta cell function

Autor: Blanca Rubi, P. B. M. de Andrade, Johannes A Maassen, Francesca Frigerio, J. M. W. van den Ouweland, Pierre Maechler

Publikováno v: Diabetologia. 49:1816-1826

Aims/hypothesis: Mitochondrial DNA (mtDNA) mutations cause several diseases, including mitochondrial inherited diabetes and deafness (MIDD), typically associated with the mtDNA A3243G point mutation on tRNALeu gene. The common hypothesis to explain t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84f09a3fb4b6eccc5829b77564bf5db
https://doi.org/10.1007/s00125-006-0301-9

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Dopamine D2-like Receptors Are Expressed in Pancreatic Beta Cells and Mediate Inhibition of Insulin Secretion

Autor: Sanda Ljubicic, Pierre Maechler, Stefania Carobbio, Mathieu Pierre Jean Armanet, Shirin Pournourmohammadi, Blanca Rubi, Clarissa Bartley

Publikováno v: Journal of Biological Chemistry. 280:36824-36832

Dopamine signaling is mediated by five cloned receptors, grouped into D1-like (D1 and D5) and D2-like (D2, D3 and D4) families. We identified by reverse transcription-PCR the presence of dopamine receptors from both families in INS-1E insulin-secreti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee0a5f82410ed4c4288166d410efc60
https://doi.org/10.1074/jbc.m505560200

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New insights into amino acid metabolism, β-cell function and diabetes

Autor: Lorraine Brennan, Blanca Rubi, Philip Newsholme, Pierre Maechler

Publikováno v: Clinical Science. 108:185-194

Specific amino acids are now known to acutely and chronically regulate insulin secretion from pancreatic β-cells in vivo and in vitro. Understanding the molecular mechanisms by which amino acids regulate insulin secretion may identify novel targets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64de1ab6eb250101b56275412f07b08e
https://doi.org/10.1042/cs20040290

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Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells

Autor: Claes B. Wollheim, Sten Theander, Blanca Rubi, Gaelle Chaffard, Arnaud Merglen, Pierre Maechler

Publikováno v: Endocrinology, Vol. 145, No 2 (2004) pp. 667-78

Rat insulinoma-derived INS-1 cells constitute a widely used β-cell surrogate. However, due to their nonclonal nature, INS-1 cells are heterogeneous and are not stable over extended culture periods. We have isolated clonal INS-1E cells from parental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c60b2f11da5d456fa3f9a1df46d0706
https://doi.org/10.1210/en.2003-1099

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Minireview: new roles for peripheral dopamine on metabolic control and tumor growth: let's seek the balance

Autor: Pierre Maechler, Blanca Rubi

Publikováno v: Endocrinology, Vol. 151, No 12 (2010) pp. 5570-5581

In peripheral tissues, dopamine is released from neuronal cells and is synthesized within specific parenchyma. Dopamine released from sympathetic nerves predominantly contributes to plasma dopamine levels. Despite growing evidence for peripheral sour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e6cc44bac370d39a3858ef095c6e56
https://archive-ouverte.unige.ch/unige:21274

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