Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Blake R. Wilde"'
Autor:
Andrew C. Cicchetto, Elsie C. Jacobson, Hannah Sunshine, Blake R. Wilde, Abigail S. Krall, Kelsey E. Jarrett, Leslie Sedgeman, Martin Turner, Kathrin Plath, M. Luisa Iruela-Arispe, Thomas Q. de Aguiar Vallim, Heather R. Christofk
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112411- (2023)
Summary: Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have
Externí odkaz:
https://doaj.org/article/73e0963b38cb4fecacd111d48dec773f
Autor:
Blake R. Wilde, Mohan R. Kaadige, Katrin P. Guillen, Andrew Butterfield, Bryan E. Welm, Donald E. Ayer
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Background Protein synthesis is regulated by the availability of amino acids, the engagement of growth factor signaling pathways, and adenosine triphosphate (ATP) levels sufficient to support translation. Crosstalk between these inputs is ex
Externí odkaz:
https://doaj.org/article/c974fd6b85e94429a1a2e9d12bfd477a
Publikováno v:
eLife, Vol 8 (2019)
Human MondoA requires glucose as well as other modulatory signals to function in transcription. One such signal is acidosis, which increases MondoA activity and also drives a protective gene signature in breast cancer. How low pH controls MondoA tran
Externí odkaz:
https://doaj.org/article/50f60afc6daa47ce983e4e0950819793
Autor:
Eric Lu, Shantao Li, Kathryn E. Hatchell, Heather R. Christofk, Blake R. Wilde, Brian Shuch, Keith Nykamp, Shirin Zavoshi, Liying Zhang, Sarah M. Nielsen, Karen Ouyang, Edward D. Esplin, Paul C. Boutros
Publikováno v:
Cancer
Cancer, vol 128, iss 4
Cancer, vol 128, iss 4
BackgroundGermline variants in fumarate hydratase (FH) are associated with autosomal dominant (AD) hereditary leiomyomatosis and renal cell cancer (HLRCC) and autosomal recessive (AR) fumarase deficiency (FMRD). The prevalence and cancer penetrance a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9329cf780776a08eb9465747082db076
https://doi.org/10.1002/cncr.33997
https://doi.org/10.1002/cncr.33997
Autor:
Blake R. Wilde, Nishma Chakraborty, Nedas Matulionis, Stephanie Hernandez, Daiki Ueno, Michayla E. Gee, Edward D. Esplin, Karen Ouyang, Keith Nykamp, Brian Shuch, Heather R. Christofk
The tricarboxylic citric acid cycle enzyme fumarate hydratase (FH) is a tumor suppressor. When lost in cells, its substrate fumarate accumulates to mM levels and drives oncogenic signaling and transformation. Germline alterations lead to an autosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5131d506b35353d08376cdeda3b6e78
https://doi.org/10.1101/2022.08.15.504023
https://doi.org/10.1101/2022.08.15.504023
Autor:
Tian-Yeh Lim, Blake R. Wilde, Mallory L. Thomas, Kristin E. Murphy, Jeffery M. Vahrenkamp, Megan E. Conway, Katherine E. Varley, Jason Gertz, Donald E. Ayer
The c-Myc protooncogene places a demand on glucose uptake to drive glucose-dependent biosynthetic pathways. To meet this demand, c-Myc protein (Myc henceforth) drives the expression of glucose transporters, glycolytic enzymes, and represses the expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c095c4de15b8195797ad13ac6cc9951
https://doi.org/10.1101/2022.08.04.502753
https://doi.org/10.1101/2022.08.04.502753
Autor:
Katrin P. Guillen, Andrew Butterfield, Bryan E. Welm, Donald E. Ayer, Mohan R. Kaadige, Blake R. Wilde
Publikováno v:
Cancer & Metabolism
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-13 (2020)
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-13 (2020)
Background Protein synthesis is regulated by the availability of amino acids, the engagement of growth factor signaling pathways, and adenosine triphosphate (ATP) levels sufficient to support translation. Crosstalk between these inputs is extensive,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5437f42f799e4ad96703f1c52e095bb3
https://doi.org/10.21203/rs.3.rs-39919/v2
https://doi.org/10.21203/rs.3.rs-39919/v2
Autor:
Heather R. Christofk, Blake R. Wilde
Publikováno v:
Molecular Cell. 80:762-763
Summary Lactate initiates Mg2+ release from the ER and subsequent uptake by the mitochondria.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20c9c3af7fab228e1b67c21c8dcefa2f
https://doi.org/10.1016/j.molcel.2020.11.023
https://doi.org/10.1016/j.molcel.2020.11.023
Autor:
William J. Sullivan, Milica Momcilovic, Daniel Braas, Utpal Banerjee, Andrew E. Whiteley, Ernst W. Schmid, David Jelinek, William E. Lowry, Peter J. Mullen, Matthew B. Maxwell, Mark S. Sharpley, Hilary A. Coller, Donald E. Ayer, David B. Shackelford, Thomas Q. de Aguiar Vallim, Blake R. Wilde, Aimee Flores, Heather R. Christofk
Publikováno v:
Cell, vol 175, iss 1
The metabolic state of a cell is influenced by cell-extrinsic factors, including nutrient availability and growth factor signaling. Here, we present extracellular matrix (ECM) remodeling as another fundamental node of cell-extrinsic metabolic regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c96199e1b89ffdcbcc9314a9aa530b
https://escholarship.org/uc/item/3x99h8gq
https://escholarship.org/uc/item/3x99h8gq