Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Blake Lee Neubauer"'
Autor:
Blake Lee Neubauer, Jianyong Shou, Stephen Parsons, Robin L. Goode, Ann M. McNulty, David Monteith, Eric G. Marcusson, Nicholas M. Dean, Thomas M. Vincent, Julia H. Carter, Larry E. Douglass, Louis Stancato, Hong Zhang, Rebecca L. Lynch, Andrew Capen, Kerry L. Blanchard, Phil Schwier, Sean E. Sissons, Karen Cox, Michele Dowless, Spring Weir, Yuefeng Chen, Jeremy R. Graff, Tao Wang, Sandaruwan Geeganage, Lillian Sams, Bruce W. Konicek
Publikováno v:
Journal of Clinical Investigation. 117:2638-2648
Expression of eukaryotic translation initiation factor 4E (eIF4E) is commonly elevated in human and experimental cancers, promoting angiogenesis and tumor growth. Elevated eIF4E levels selectively increase translation of growth factors important in m
Autor:
Philip W. Iversen, Terrence M. Katona, Shaobo Zhang, Liang Cheng, Lee Ann Baldridge, Blake Lee Neubauer
Publikováno v:
Clinical Cancer Research. 11:8358-8363
Purpose: Angiogenin is a polypeptide involved in the formation and establishment of new blood vessels necessary for growth and metastasis of numerous malignant neoplasms, including prostatic adenocarcinoma. Antiangiogenin therapy inhibits the establi
Autor:
Paul Wissel, Geert J. C. M. Kolvenbag, Blake Lee Neubauer, Joanne Waldstreicher, Donald L. Trump
Publikováno v:
Urology. 57:64-67
This article summarizes discussions of the importance of androgens and androgen antagonists in the genesis of prostate cancer. These discussions occurred at a recent symposium on prostate cancer chemoprevention sponsored by the National Cancer Instit
Autor:
James E. Audia, Ann M. McNulty, Kerry G. Bemis, Blake Lee Neubauer, Vincent Patrick Rocco, Robin L. Goode
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 72:13-21
Type I and type II steroid 5alpha-reductases (5alpha-R) catalyze the conversion of testosterone (T) to dihydrotestosterone (DHT). LY320236 is a benzoquinolinone (BQ) that inhibits 5alpha-R activity in human scalp skin (Ki(typeI)=28.7+/-1.87 nM) and p
Autor:
Hermann Robert Bell, Trevor J. Howe, William McCoull, Stephen L. Cooper, Gerald W. Becker, Beining Chen, Blake Lee Neubauer, Ann M. McNulty, Gareth J. Pritchard, Robert M. Adlington, Jack E. Baldwin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1689-1694
A novel series of monocyclic β-lactam analogues was designed using a homology derived model of prostate specific antigen (PSA) and by application of a multiple copy simultaneous search technique. Syntheses were conducted by assembly of the β-lactam
Autor:
Ilan Leibovitch, Debra M. Sutkowski, Kenneth C. Hsiao, James E. Audia, Robin L. Goode, Blake Lee Neubauer, Ann M. McNulty
Publikováno v:
The Prostate. 29:62-66
We evaluated the metabolic inhibitory, antiproliferative, and antisecretory effects of LY300502, a benzoquinolinone human-specific type I-selective steroid 5α-reductase inhibitor in LNCaP human prostatic adenocarcinoma cell cultures. Reductive metab
Autor:
Kevin L. Best, Carl Joseph Shaar, Blake Lee Neubauer, Robin L. Goode, Dennis M. Hoover, Sarosdy Mf, Counts Df, Charles David Jones, Lee R. Tanzer, Ronald L. Merriman
Publikováno v:
The Prostate. 27:220-229
The benzothiophene antiestrogen, raloxifene (LY156758), has selective estrogen pharmacological antagonist activity in rats. The PAIII rat prostatic adenocarcinoma model was used to evaluate the effects of this agent on the lymphatic and pulmonary met
Publikováno v:
American Journal of Hypertension. 7:838-843
Ambulatory blood pressure monitoring (ABPM) was used as an effective methodology by a primary care physician to assess normalcy of blood pressure (BP) and heart rate during pregnancy. One hundred fifty pregnant women in one of three periods (18 to 22
Autor:
Nancy B. Stamm, David W. Russell, Blake Lee Neubauer, Stefan Andersson, Loretta Ames Mcquaid, James E. Audia, Richard E. Toomey, Kenneth Steven Hirsch, Pam Pennington, Charles David Jones
Publikováno v:
Proceedings of the National Academy of Sciences. 90:5277-5281
Androgens, in particular dihydrotestosterone (DHT), play a key role in differentiation, growth, and maintenance of the mammalian prostate. Production of DHT from testosterone is catalyzed by two distinct membrane-bound steroid 5 alpha-reductase [5 al
Autor:
Kevin L. Best, Richard E. Toomey, Cynthia A. Gates, Dennis M. Hoover, Carl Joseph Shaar, Robin L. Goode, Charles David Jones, James A. Clemens, Blake Lee Neubauer, Marie E. Laughlin
Publikováno v:
The Prostate. 23:245-262
The benzothiophene anti-estrogen, raloxifene [LY156758; (6-hydroxy-2-(4-hydroxyphenyl) benzo(b)thien-3-yl)(4-(2-1-piperidinyl)ethoxy)phenyl methanone hydrochloride] has selective estrogen pharmacological antagonist activity in female rats. The presen