Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Blake L. Torrance"'
Autor:
Dominique E. Martin, Andreia N. Cadar, Hunter Panier, Blake L. Torrance, George A. Kuchel, Jenna M. Bartley
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Aging is associated with progressive declines in immune responses leading to increased risk of severe infection and diminished vaccination responses. Influenza (flu) is a leading killer of older adults despite availability of seas
Externí odkaz:
https://doaj.org/article/174196bb8f364bd0ae00e27a3165f380
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
Cellular senescence has been implicated in the pathophysiology of many age-related diseases. However, it also plays an important protective role in the context of tumor suppression and wound healing. Reducing senescence burden through treatment with
Externí odkaz:
https://doaj.org/article/4201bd82f293496a89d3d9cc3a7cc1bd
Autor:
Blake L. Torrance, Andreia N. Cadar, Dominique E. Martin, Hunter A. Panier, Erica C. Lorenzo, Jenna M. Bartley, Ming Xu, Laura Haynes
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
Age is the greatest risk factor for adverse outcomes following influenza (flu) infection. The increased burden of senescent cells with age has been identified as a root cause in many diseases of aging and targeting these cells with drugs termed senol
Externí odkaz:
https://doaj.org/article/546a5fe5c73d485e8a139236c8c777fe
Autor:
Blake L. Torrance, Laura Haynes
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Aging results in systemic changes that leave older adults at much higher risk for adverse outcomes following respiratory infections. Much work has been done over the years to characterize and describe the varied changes that occur with aging from the
Externí odkaz:
https://doaj.org/article/0c9d64480f51432eb3af53f6cbe503ed
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
It is well known that aging is associated with dysregulated metabolism. This is seen both in terms of systemic metabolism, as well as at the cellular level with clear mitochondrial dysfunction. More recently, the importance of cellular metabolism in
Externí odkaz:
https://doaj.org/article/16ef51d5366b47bd932393f165bd34df
Autor:
Elizabeth Ann Bonney, Kendall Krebs, Jihye Kim, Kirtika Prakash, Blake L. Torrance, Laura Haynes, Mercedes Rincon
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Respiratory diseases adversely affect infants and are the focus of efforts to develop vaccinations and other modalities to prevent disease. The infant immune system differs from that of older children and adults in many ways that are as yet ill under
Externí odkaz:
https://doaj.org/article/9f064a6e270a4641a765e9e64500849a
Autor:
Spencer R. Keilich, Andreia N. Cadar, Darcy T. Ahern, Blake L. Torrance, Erica C. Lorenzo, Dominique E. Martin, Laura Haynes, Jenna M. Bartley
Publikováno v:
GeroScience.
Autor:
Spencer R. Keilich, Andreia N. Cadar, Darcy T. Ahern, Blake L. Torrance, Erica C. Lorenzo, Dominique E. Martin, Laura Haynes, Jenna M. Bartley
Publikováno v:
GeroScience
Older adults have diminished immune responses that increase susceptibility to infectious diseases, such as influenza (flu). In older adults, flu infection can lead to hospitalization, catastrophic disability, and mortality. We previously demonstrated
Autor:
Erica C. Lorenzo, Blake L. Torrance, Spencer R. Keilich, Iman Al‐Naggar, Andrew Harrison, Ming Xu, Jenna M. Bartley, Laura Haynes
Publikováno v:
Aging Cell
Aging and senescence impact CD4 T helper cell (Th) subset differentiation during influenza infection. In the lungs of infected aged mice, there were significantly greater percentages of Th cells expressing the transcription factor FoxP3, indicative o
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
It is well known that aging is associated with dysregulated metabolism. This is seen both in terms of systemic metabolism, as well as at the cellular level with clear mitochondrial dysfunction. More recently, the importance of cellular metabolism in