Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Blake H. Albright"'
Autor:
Andrew J. Crowther, Szu-Aun Lim, Brent Asrican, Blake H. Albright, Josh Wooten, Chia-Yu Yeh, Hechen Bao, Domenic H. Cerri, Jessica Hu, Yen-Yu Ian Shih, Aravind Asokan, Juan Song
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 1146-1159 (2018)
Summary: Quiescent neural stem cells (qNSCs) with radial morphology are the only proven source of new neurons in the adult mammalian brain. Our understanding of the roles of newly generated neurons depends on the ability to target and manipulate adul
Externí odkaz:
https://doaj.org/article/5d912917b24046a696840e8154d8e10a
Autor:
Giridhar Murlidharan, Garrett E. Berry, Ruth M. Castellanos Rivera, Blake H. Albright, Claire M. Storey, Victoria J. Madigan, Aravind Asokan
Publikováno v:
Molecular Therapy. 26:510-523
Effective gene delivery to the CNS by intravenously administered adeno-associated virus (AAV) vectors requires crossing the blood-brain barrier (BBB). To achieve therapeutic CNS transgene expression, high systemic vector doses are often required, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7871313ef0a51de37395f586b7f972
https://doi.org/10.1016/j.ymthe.2017.10.017
https://doi.org/10.1016/j.ymthe.2017.10.017
Publikováno v:
Journal of Virology. 93
Central nervous system (CNS) transduction by systemically administered recombinant adeno-associated viral (AAV) vectors requires crossing the blood-brain barrier (BBB). We recently mapped a structural footprint on the AAVrh.10 capsid, which, when gra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ab7420706cf72c984b113c6cadd7fd
https://doi.org/10.1128/jvi.00332-19
https://doi.org/10.1128/jvi.00332-19
Autor:
Domenic H. Cerri, Yen-Yu Ian Shih, Chia-Yu Yeh, Josh Wooten, Szu Aun Lim, Brent Asrican, Blake H. Albright, Hechen Bao, Jessica Hu, Andrew J. Crowther, Aravind Asokan, Juan Song
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 10, Iss 3, Pp 1146-1159 (2018)
Stem Cell Reports, Vol 10, Iss 3, Pp 1146-1159 (2018)
Summary Quiescent neural stem cells (qNSCs) with radial morphology are the only proven source of new neurons in the adult mammalian brain. Our understanding of the roles of newly generated neurons depends on the ability to target and manipulate adult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5a492a3320f38b235a66857dbf9b0f
https://pubmed.ncbi.nlm.nih.gov/29478897
https://pubmed.ncbi.nlm.nih.gov/29478897
Autor:
Yu-Shan Tseng, Scott W.J. McPhee, Wuping Li, R. Jude Samulski, Mavis Agbandje-McKenna, Aravind Asokan, Chengwen Li, Shuqing Wu, Matthew L. Hirsch, Blake H. Albright
A major hindrance in gene therapy trials with adeno-associated virus (AAV) vectors is the presence of neutralizing antibodies (NAbs) that inhibit AAV transduction. In this study, we used directed evolution techniques in vitro and in mouse muscle to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1dc908d8e806067314b7b3af0f02a0
https://europepmc.org/articles/PMC4754536/
https://europepmc.org/articles/PMC4754536/
Autor:
Aravind Asokan, John A. Chiorini, Mavis Agbandje-McKenna, Blake H. Albright, Lavanya Rao, Victoria J. Madigan
Publikováno v:
Molecular Therapy. 23
Most AAV strains in clinical development display a broad range of cellular tropisms within the central nervous system (CNS). As such, this current panel of vectors provides several options for efficient gene expression within neurons and/or glia in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9954af14229fb23bf4faf969f42eaf
Publikováno v:
Molecular Therapy. 23:S18-S19
Recent studies have demonstrated that AAV gene transfer efficiency and tropism, particularly with regard to the liver, can vary markedly across animal species. A mechanistic understanding of such host-specific AAV transduction profiles is essential f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29178c3cbdc36af8979416d7793ce474
https://doi.org/10.1016/s1525-0016(16)33647-4
https://doi.org/10.1016/s1525-0016(16)33647-4