Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Blake D. Jardin"'
Autor:
Fujian Lu, Qing Ma, Wenjun Xie, Carter L. Liou, Donghui Zhang, Mason E. Sweat, Blake D. Jardin, Francisco J. Naya, Yuxuan Guo, Heping Cheng, William T. Pu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Heart muscle cells exhibit exquisitely organized subcellular features that enable efficient and coordinated heart muscle contraction, but little is known about how it is achieved. Here the authors show that CMYA5 organizes cardiomyocyte calcium relea
Externí odkaz:
https://doaj.org/article/e12393a3286b484db96f093687dad036
Autor:
Yuxuan Guo, Blake D. Jardin, Pingzhu Zhou, Isha Sethi, Brynn N. Akerberg, Christopher N Toepfer, Yulan Ai, Yifei Li, Qing Ma, Silvia Guatimosim, Yongwu Hu, Grigor Varuzhanyan, Nathan J. VanDusen, Donghui Zhang, David C. Chan, Guo-Cheng Yuan, Christine E. Seidman, Jonathan G. Seidman, William T. Pu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
The processes regulating cardiomyocyte (CM) maturation are unclear. Here, the authors show that serum response factor regulates CM maturation only in neonatal CMs through stage-specific chromatin occupancy that affects cell size, sarcomere and transv
Externí odkaz:
https://doaj.org/article/79b67194c3e44f45957af9c4b8ff1945
Autor:
Pingzhu Zhou, Yan Zhang, Isha Sethi, Lincai Ye, Michael A. Trembley, Yangpo Cao, Brynn N. Akerberg, Feng Xiao, Xiaoran Zhang, Kai Li, Blake D. Jardin, Neil Mazumdar, Qing Ma, Aibin He, Bin Zhou, William T. Pu
Publikováno v:
Circulation research. 131(11)
Background: The pioneer transcription factor (TF) GATA4 (GATA Binding Protein 4) is expressed in multiple cardiovascular lineages and is essential for heart development. GATA4 lineage-specific occupancy in the developing heart underlies its lineage s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd83fc64a62f9b9aab334cb3268ff2a9
https://pubmed.ncbi.nlm.nih.gov/36263775
https://pubmed.ncbi.nlm.nih.gov/36263775
Autor:
Yuxuan Guo, Yangpo Cao, Blake D Jardin, Xiaoran Zhang, Pingzhu Zhou, Silvia Guatimosim, Junsen Lin, Zhan Chen, Yueyang Zhang, Neil Mazumdar, Fujian Lu, Qing Ma, Yao-Wei Lu, Mingming Zhao, Da-Zhi Wang, Erdan Dong, William T Pu
Publikováno v:
Cardiovasc Res
Calcium handling capacity is a major gauge of cardiomyocyte maturity. Ryanodine receptor 2 (RYR2) is the predominant calcium channel that releases calcium from the sarcoplasmic reticulum/endoplasmic reticulum (SR/ER) to activate cardiomyocyte contrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85bf1e57d9deeb5b3d814c74f98977e
https://doi.org/10.1093/cvr/cvac077
https://doi.org/10.1093/cvr/cvac077
Autor:
Fujian Lu, Qing Ma, Wenjun Xie, Carter L. Liou, Donghui Zhang, Mason E. Sweat, Blake D. Jardin, Francisco J. Naya, Yuxuan Guo, Heping Cheng, William T. Pu
Publikováno v:
Nature communications. 13(1)
Cardiac excitation-contraction coupling requires dyads, the nanoscopic microdomains formed adjacent to Z-lines by apposition of transverse tubules and junctional sarcoplasmic reticulum. Disruption of dyad architecture and function are common features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cabf21d5fa63eaca648177b974f1c5
https://pubmed.ncbi.nlm.nih.gov/35449169
https://pubmed.ncbi.nlm.nih.gov/35449169
Autor:
Guo-Cheng Yuan, Yuxuan Guo, Eric M. Small, Qing Ma, Michael A. Trembley, Alan H. Beggs, Behzad Moghadaszadeh, Emily C Troiano, Blake D. Jardin, Yangpo Cao, Isha Sethi, Neil Mazumdar, William T. Pu
Publikováno v:
Proc Natl Acad Sci U S A
The paucity of knowledge about cardiomyocyte maturation is a major bottleneck in cardiac regenerative medicine. In development, cardiomyocyte maturation is characterized by orchestrated structural, transcriptional, and functional specializations that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a68716eed2520b43d1bba0c2aecf3c6
https://pubmed.ncbi.nlm.nih.gov/33361330
https://pubmed.ncbi.nlm.nih.gov/33361330
Publikováno v:
Circulation Research. 127
Cardiomyocyte (CM) maturation is an essential step in heart development that prepares the organ for robust and sustainable contractions. However, very little is known about the contribution of CM maturation to cardiac pathogenesis, partly due to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e25c4c93cb241145dc188a9a70b5bf67
https://doi.org/10.1161/res.127.suppl_1.mp120
https://doi.org/10.1161/res.127.suppl_1.mp120
Autor:
Yongwu Hu, Yuxuan Guo, Pingzhu Zhou, Yifei Li, Christopher N. Toepfer, Nathan J. VanDusen, Blake D. Jardin, Silvia Guatimosim, Isha Sethi, Jonathan G. Seidman, Brynn N. Akerberg, David C. Chan, Yulan Ai, Christine E. Seidman, Qing Ma, William T. Pu, Grigor Varuzhanyan, Donghui Zhang, Guo-Cheng Yuan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
After birth, cardiomyocytes (CM) acquire numerous adaptations in order to efficiently pump blood throughout an animal’s lifespan. How this maturation process is regulated and coordinated is poorly understood. Here, we perform a CRISPR/Cas9 screen i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a55c7538c4ffbb3b5225e839694c1b2
https://doaj.org/article/79b67194c3e44f45957af9c4b8ff1945
https://doaj.org/article/79b67194c3e44f45957af9c4b8ff1945
Autor:
Silvia Guatimosim, Nathan J. VanDusen, Yuxuan Guo, Blake D. Jardin, Guo-Cheng Yuan, Lina Zhang, Yulan Ai, Long-Sheng Song, Ang Guo, Donghui Zhang, Qing Ma, Biyi Chen, Isha Sethi, William T. Pu, Weiliang Gu
Publikováno v:
Circulation Research. 120:1874-1888
Rationale: Loss-of-function studies in cardiac myocytes (CMs) are currently limited by the need for appropriate conditional knockout alleles. The factors that regulate CM maturation are poorly understood. Previous studies on CM maturation have been c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b4b04363caf3afdb3e064b8d28f8040
https://doi.org/10.1161/circresaha.116.310283
https://doi.org/10.1161/circresaha.116.310283
Autor:
Blake D. Jardin, Emily C Troiano, Behzad Moghadaszadeh, Yuxuan Guo, Isha Sethi, William T. Pu, Michael A. Trembley, Eric M. Small, Guo-Cheng Yuan, Qing Ma, Alan H. Beggs
Cardiomyocyte maturation is essential for robust heart contraction throughout life. The signaling networks governing cardiomyocyte maturation remain poorly defined. Our prior studies established the transcription factor SRF as a key regulator of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238b043814854f2a3afbd96a000251dd
https://doi.org/10.1101/824185
https://doi.org/10.1101/824185
