Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Blake C. Barrington"'
Autor:
Praveen R. Juvvadi, David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, Jackie J. Lin, Anna Floyd Averette, D. Christopher Cole, Blake C. Barrington, Joshua D. Wheaton, Maria Ciofani, Michael Trzoss, Xiaoming Li, Soo Chan Lee, Ying-Lien Chen, Mitchell Mutz, Leonard D. Spicer, Maria A. Schumacher, Joseph Heitman, William J. Steinbach
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
FK506 is a potential antifungal compound that inhibits calcineurin, but it also has immunosuppressive activity. Here, Juvvadi et al. report the structure of FK506 in complex with the FK506-binding protein FKPB12 and calcineurin, and design a less imm
Externí odkaz:
https://doaj.org/article/4b8d65315776423982c1bea6612cead9
Autor:
Sophie M. C. Gobeil, Leonard D. Spicer, David A. Fox, Jackie J. Lin, Maria Ciofani, William J. Steinbach, Michael J. Hoy, Praveen R. Juvvadi, Ronald A. Venters, Blake C. Barrington, Zanetta Chang, Maria A. Schumacher, Anna F. Averette, Joseph Heitman, Michael Trzoss, Mitchell Mutz, Ying-Lien Chen, Joshua D. Wheaton, Xiaoming Li, Soo Chan Lee, Benjamin G. Bobay, D. Christopher Cole
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nature Communications
Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) and regulatory (CnB) subu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e25dca73de3347142bc94a3eb686547
https://doi.org/10.1038/s41467-019-12199-1
https://doi.org/10.1038/s41467-019-12199-1
Autor:
Yohannes G. Asfaw, William J. Steinbach, Blake C. Barrington, Praveen R. Juvvadi, Greg Waitt, M. Arthur Moseley, E. Keats Shwab, Erik J. Soderblom
Publikováno v:
Mol Microbiol
Calcium signaling through calcineurin and its major transcription factor, CrzA, is integral to hyphal growth, stress response, and virulence of the pathogenic fungus Aspergillus fumigatus, the leading etiology of invasive aspergillosis. Dephosphoryla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2196fa24279bf2320444b1ccc836345b
https://pubmed.ncbi.nlm.nih.gov/30927289
https://pubmed.ncbi.nlm.nih.gov/30927289