Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Blake A. Winn"'
Autor:
Jeni Gerberich, Ralph P. Mason, Bunnarack Kuch, Blake A. Winn, Mary Lynn Trawick, Zhe Shi, Matthew T. MacDonough, Alejandro J. Ramirez, Tracy E. Strecker, Peter David Davis, Laxman Devkota, Yifan Wang, Ernest Hamel, Deboprosad Mondal, David J. Chaplin, Kevin G. Pinney
Publikováno v:
J Nat Prod
The natural products combretastatin A-1 (CA1) and combretastatin A-4 (CA4) function as potent inhibitors of tubulin polymerization and as selective vascular disrupting agents (VDAs) in tumors. Bioreductively activatable prodrug conjugates (BAPCs) can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98a96b6fc7d84ea825bc5dbd3a475b3
https://pubmed.ncbi.nlm.nih.gov/32196334
https://pubmed.ncbi.nlm.nih.gov/32196334
Autor:
Ernest Hamel, R. David Ross, Benson L. Nguyen, Evan M. Kelly, David J. Chaplin, Mary Lynn Trawick, Blake A. Winn, Kevin G. Pinney, Zhe Shi, Yifan Wang, Graham J. Carlson
A variety of solid tumor cancers contain significant regions of hypoxia, which provide unique challenges for targeting by potent anticancer agents. Bioreductively activatable prodrug conjugates (BAPCs) represent a promising strategy for therapeutic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26afcf4248d980d47c16b1e8d7166280
https://europepmc.org/articles/PMC5319644/
https://europepmc.org/articles/PMC5319644/
Autor:
David J. Chaplin, Li Liu, Blake A. Winn, Jeni Gerberich, Alex Winters, Yifan Wang, Kevin G. Pinney, Laxman Devkota, Ralph P. Mason, Tracy E. Strecker, Matthew T. MacDonough, Mary Lynn Trawick
Publikováno v:
Cancer Research. 77:3203-3203
Regions of pronounced hypoxia in malignant tumors represent an opportunity for selectivity in drug activation, and hence targeting and delivery. In this study, a series of bioreductively activatable prodrug conjugates (BAPCs) of small-molecule inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5121776d07bcef11ae49f05597a0654
https://doi.org/10.1158/1538-7445.am2017-3203
https://doi.org/10.1158/1538-7445.am2017-3203