Výsledky vyhledávání - "Blake A. Rowe"

PISA, A novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ

Autor: Philip Jones, Laura S. Lubbers, Blake A. Rowe, Fred Hess, Susan E. Browne, Ian J. Reynolds, Lisa M. Hodge, Richard Gundersdorf

Publikováno v: Journal of Pharmacological and Toxicological Methods. 61:319-328

Poly ADP-ribose polymerase (PARP) maintains genomic integrity by repairing DNA strand breaks, however over-activation of PARP following neural tissue injury is hypothesized to cause neuronal death. Therefore, PARP inhibitors have potential for limiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35046a3f23db77bad33b4ae5a5c86dd
https://doi.org/10.1016/j.vascn.2010.01.012

Zobrazit plný text záznamu

Transposition of Three Amino Acids Transforms the Human Metabotropic Glutamate Receptor (mGluR)-3-Positive Allosteric Modulation Site to mGluR2, and Additional Characterization of the mGluR2-Positive Allosteric Modulation Site

Autor: Jeffrey McQuiston, Laura S. Lubbers, Lorrie P. Daggett, Theodore M. Kamenecka, Celine Bonnefous, Blake A. Rowe, Hervé Schaffhauser, Sylvia Morales

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 326:240-251

Glutamate is a major neurotransmitter in the central nervous system, and abnormal glutamate neurotransmission has been implicated in many neurological disorders, including schizophrenia, Alzheimer's disease, Parkinson's disease, addiction, anxiety, d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75e3441ec046403faa6d68a072d2e96
https://doi.org/10.1124/jpet.108.138271

Zobrazit plný text záznamu

3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2)

Autor: Joyce K. James, Hutchinson John H, Michael F. Gardner, Blake A. Rowe, Hervé Schaffhauser, Lorrie P. Daggett, Rowena V. Cube, Anthony B. Pinkerton, Jean-Michel Vernier

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:2389-2393

We have identified and synthesized a brain penetrant propanoic acid as an allosteric potentiator of the metabotropic glutamate receptor 2. Structure-activity relationship studies directed toward improving the potency, level of potentiation and brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17be6a326e0e9aef78ba2c1f2659398e
https://doi.org/10.1016/j.bmcl.2005.02.078

Zobrazit plný text záznamu

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators

Autor: Dana E. Rodriguez, Jean-Michel Vernier, Hutchinson John H, Hervé Schaffhauser, Anthony B. Pinkerton, Lorrie P. Daggett, Joyce K. James, Michael F. Gardner, Blake A. Rowe, Una Campbell, Rowena V. Cube

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:1565-1571

We have identified and synthesized a series of phenyl-tetrazolyl and 4-thiopyridyl indanones as allosteric potentiators of the metabotropic glutamate receptor 2. Structure activity relationship studies directed toward improving the potency and level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e1edf523edbd2b8328be76da134078
https://doi.org/10.1016/j.bmcl.2005.01.077

Zobrazit plný text záznamu

Phenyl-tetrazolyl Acetophenones: Discovery of Positive Allosteric Potentiatiors for the Metabotropic Glutamate 2 Receptor

Autor: Dana E. Rodriguez, Christopher Baccei, Daniel S. Lorrain, Lorrie P. Daggett, Hervé Schaffhauser, Linda J. Bristow, Blake A. Rowe, Jean-Michel Vernier, Anthony B. Pinkerton, Una Campbell

Publikováno v: Journal of Medicinal Chemistry. 47:4595-4599

Herein we disclose the discovery of a new class of positive allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2), phenyl-tetrazolyl acetophenones, e.g. 1-(2-hydroxy-3-propyl-4-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl) ethanon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b72043fb5440591709ebe94af776b29
https://doi.org/10.1021/jm040088h

Zobrazit plný text záznamu

Group II mGlu Receptor Activation Suppresses Norepinephrine Release in the Ventral Hippocampus and Locomotor Responses to Acute Ketamine Challenge

Autor: Linda J. Bristow, Blake A. Rowe, Mark A. Varney, Jean-Michel Vernier, Lucia D Correa, Daniel S. Lorrain, Dana E. Rodriguez, Christopher Baccei, Jeffery J. Anderson, Una Campbell, Hervé Schaffhauser, Anthony B. Pinkerton

Publikováno v: Neuropsychopharmacology. 28:1622-1632

Group II mGlu receptor agonists (eg LY379268 and LY354740) have been shown to reverse many of the behavioral responses to PCP as well as glutamate release elicited by PCP and ketamine. In the present set of experiments, we used in vivo microdialysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d3b1f9c253ba493db23feeebb2f68c
https://doi.org/10.1038/sj.npp.1300238

Zobrazit plný text záznamu

[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Binding to Metabotropic Glutamate Receptor Subtype 5 in Rodent Brain: In Vitro and in Vivo Characterization

Autor: Darlene R. Giracello, Blake A. Rowe, Nicholas D. P. Cosford, Mark A. Varney, Deborah F. Chapman, Margaret J. Bradbury, Jeffery J. Anderson, Lida R. Tehrani, Greg Holtz, Sara P. Rao

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 303:1044-1051

The binding of [3H]methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (methoxymethyl-MTEP), a potent and selective antagonist for metabotropic glutamate (mGlu)5 receptors, was characterized in rat brain both in vitro and in vivo. Nonspecifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02261e288431280fa923c3e0993cf6e7
https://doi.org/10.1124/jpet.102.040618

Zobrazit plný text záznamu

Cerebrospinal Fluid Levels of -Secretase--Cleaved Soluble Amyloid Precursor Protein Mirror Cognition in a Swedish Family With Alzheimer Disease and a Gene Mutation

Autor: Lars Lannfelt, Blake A. Rowe, Hans Basun, Ove Almkvist, Steven L. Wagner, Lars-Olof Wahlund

Publikováno v: Archives of Neurology. 54:641-644

Objective: To explore the relationship between possible biological markers of Alzheimer disease that are related to amyloid metabolism and mental functions. Participants: Twelve individuals from a Swedish family with Alzheimer disease and a double mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6617b25c0a73a21f63d5c32273403596
https://doi.org/10.1001/archneur.1997.00550170111022

Zobrazit plný text záznamu

Specific patterns of amyloid β-protein precursor isoform secretion and proteolysis in cultured human cells

Autor: Michael F Murphy, Steven L. Wagner, Robert Steven Siegel, Blake A. Rowe, Thomas S. Vedvick

Publikováno v: Amyloid. 3:100-109

A characteristic neuropathologic feature of Alzheimer c disease is an abundance of brain-localized neuritic plaques. These plaques are identified as areas of degenerating nerve terminals surrounding cores of aggregated and insoluble fibrils of amyloi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12e519ea44304db13e746e721ecace98
https://doi.org/10.3109/13506129609014361

Zobrazit plný text záznamu

MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice

Autor: Blake A. Rowe, Shouwu Miao, Gregory M. Dillon, Ruey-Ruey C. Huang, Jeffrey J. Hale, Jing Chen Xiao, Julie Z. Lao, Laura S. Lubbers, Mitchell T. Ferguson, Kathleen M. Rupprecht, Thomas J. Kornecook, Jean-Cosme Dodart, Tung M. Fong

Publikováno v: Behavioural pharmacology. 22(2)

Cannabinoid receptors (CBRs) play an important role in a variety of physiological functions and have been considered drug targets for obesity and psychiatric disorders. In particular, the CB1R is highly expressed in brain regions crucial to learning

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312477a70af6f68cab1aaf8cb72d7160
https://pubmed.ncbi.nlm.nih.gov/21301326

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání