Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Blake A. Richards"'
Autor:
Mariangela Panniello, Colleen J. Gillon, Roberto Maffulli, Marco Celotto, Blake A. Richards, Stefano Panzeri, Michael M. Kohl
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114244- (2024)
Summary: Neurons in the primary cortex carry sensory- and behavior-related information, but it remains an open question how this information emerges and intersects together during learning. Current evidence points to two possible learning-related cha
Externí odkaz:
https://doaj.org/article/1e06c75032e44f7cbc888d7627e033c8
Autor:
Colleen J. Gillon, Jérôme A. Lecoq, Jason E. Pina, Ruweida Ahmed, Yazan N. Billeh, Shiella Caldejon, Peter Groblewski, Timothy M. Henley, India Kato, Eric Lee, Jennifer Luviano, Kyla Mace, Chelsea Nayan, Thuyanh V. Nguyen, Kat North, Jed Perkins, Sam Seid, Matthew T. Valley, Ali Williford, Yoshua Bengio, Timothy P. Lillicrap, Joel Zylberberg, Blake A. Richards
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-14 (2023)
Abstract The apical dendrites of pyramidal neurons in sensory cortex receive primarily top-down signals from associative and motor regions, while cell bodies and nearby dendrites are heavily targeted by locally recurrent or bottom-up inputs from the
Externí odkaz:
https://doaj.org/article/31dd7e4745f64242ac4b34677d2073ab
Autor:
Luke Y. Prince, Matthew M. Tran, Dorian Grey, Lydia Saad, Helen Chasiotis, Jeehyun Kwag, Michael M. Kohl, Blake A. Richards
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
In order to address whether distinct subtypes of neurons are more sensitive to information carried by synchrony versus rate, Prince et al. used optical stimulation in slices of somatosensory cortex from mouse lines labelling fast-spiking (FS) and reg
Externí odkaz:
https://doaj.org/article/ee0eb814510845bd974628b6e520e8f3
Publikováno v:
Frontiers in Computational Neuroscience, Vol 16 (2022)
Forgetting is a normal process in healthy brains, and evidence suggests that the mammalian brain forgets more than is required based on limitations of mnemonic capacity. Episodic memories, in particular, are liable to be forgotten over time. Research
Externí odkaz:
https://doaj.org/article/1c2d4efe82234b939b9505a1e1cfe2d9
Publikováno v:
Frontiers in Computer Science, Vol 4 (2022)
It is commonly assumed that usage of the word “computer” in the brain sciences reflects a metaphor. However, there is no single definition of the word “computer” in use. In fact, based on the usage of the word “computer” in computer scien
Externí odkaz:
https://doaj.org/article/3f82f1c06ec14f19923bdc5f60b9fa94
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background Abnormal accumulation of amyloid β1–42 oligomers (AβO1–42), a hallmark of Alzheimer’s disease, impairs hippocampal theta-nested gamma oscillations and long-term potentiation (LTP) that are believed to underlie learning and
Externí odkaz:
https://doaj.org/article/3df85762d90a49b5b4b8e05b262dfc8f
Publikováno v:
The Journal of Physiology.
Publikováno v:
Neuroscience. 489:200-215
Neurons are very complicated computational devices, incorporating numerous non-linear processes, particularly in their dendrites. Biophysical models capture these processes directly by explicitly modelling physiological variables, such as ion channel
Autor:
Lina M. Tran, Adam Santoro, Lulu Liu, Sheena A. Josselyn, Blake A. Richards, Paul W. Frankland
Publikováno v:
Proceedings of the National Academy of Sciences. 119
New neurons are continuously generated in the subgranular zone of the dentate gyrus throughout adulthood. These new neurons gradually integrate into hippocampal circuits, forming new naive synapses. Viewed from this perspective, these new neurons may
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 8, p e1006315 (2018)
Symptoms of schizophrenia may arise from a failure of cortical circuits to filter-out irrelevant inputs. Schizophrenia has also been linked to disruptions in cortical inhibitory interneurons, consistent with the possibility that in the normally funct
Externí odkaz:
https://doaj.org/article/331d91d867dc4e2fb2c33a3ae7789d8f