Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Blake A. Jacobson"'
Publikováno v:
Translational Oncology, Vol 13, Iss 7, Pp 100782- (2020)
Oncolytic viruses have demonstrated efficacy in numerous tumor models including non-small cell lung cancer (NSCLC). One limitation of viral therapy for metastatic lung cancer is that systemic administration can be hindered by complement and antiviral
Externí odkaz:
https://doaj.org/article/b8a08c9a21bb4526bddc77af94aecb4d
Autor:
Manish R. Patel, Carston R. Wagner, Sierra Chen, Nicolas Vattendahl Vidal, Aniekan Okon, Gabriel W. Vattendahl Vidal, Blake A. Jacobson, Zeeshan Ahmad, Mitchell W. McDonald, Robert A. Kratzke, Maxwell Dillenburg
Publikováno v:
Cancer Chemotherapy and Pharmacology. 85:425-432
Activated cap-dependent translation promotes cancer by stimulating translation of mRNAs encoding malignancy-promoting proteins. The nucleoside monophosphate Protide, 4Ei-10, undergoes intracellular uptake and conversion by Hint1 to form 7-Cl-Ph-Ethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::febd68435195aba1430a9f61ca546cbb
https://doi.org/10.1007/s00280-020-04029-9
https://doi.org/10.1007/s00280-020-04029-9
Autor:
Alexander S. Dash, Blake A. Jacobson, Robert A. Kratzke, Manish R. Patel, Kareem A. Ismail, Yan Ji, Daniel Baumann
Publikováno v:
Cancer Gene Therapy. 26:411-418
The concept of using viruses to treat cancer has now shown proof of concept in several recent clinical trials, leading to the first FDA approval of virotherapy for melanoma last year. Vesicular stomatitis virus (VSV) is a promising oncolytic virus th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80128e657fc38817e32995e9614e9dff
https://doi.org/10.1038/s41417-018-0074-6
https://doi.org/10.1038/s41417-018-0074-6
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42fd99f069b9cfa306a17b82a3b5beb7
https://doi.org/10.1096/fasebj.2021.35.s1.01593
https://doi.org/10.1096/fasebj.2021.35.s1.01593
Autor:
Daniel A. Cambron, Manish R. Patel, Anil J. Patel, Blake A. Jacobson, Emilia Stoian, Maxwell Dillenburg, Zeeshan Ahmad, Robert A. Kratzke, Carston R. Wagner, Sierra Chen, Gabriella Waldusky
Publikováno v:
Investigational new drugs. 39(3)
In order to suppress 5' cap-mediated translation a highly available inhibitor of the interaction between the 5' mRNA cap and the eIF4E complex has been developed. 4Ei-10 is a member of the class of ProTide compounds and has elevated membrane permeabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1363a9e1461ad6d6f18ffb3e3495b0cc
https://pubmed.ncbi.nlm.nih.gov/33230623
https://pubmed.ncbi.nlm.nih.gov/33230623
Publikováno v:
Translational Oncology, Vol 13, Iss 7, Pp 100782-(2020)
Translational Oncology
Translational Oncology
Oncolytic viruses have demonstrated efficacy in numerous tumor models including non-small cell lung cancer (NSCLC). One limitation of viral therapy for metastatic lung cancer is that systemic administration can be hindered by complement and antiviral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0906042a6f6913cfe170f715ca735bce
http://www.sciencedirect.com/science/article/pii/S1936523320302631
http://www.sciencedirect.com/science/article/pii/S1936523320302631
Autor:
Robert A. Kratzke, Marian G. Kratzke, Arpita De, Blake A. Jacobson, Joe Jay-Dixon, Manish R. Patel, Mark S. Peterson, Ahad A. Sadiq
Publikováno v:
Investigational New Drugs. 36:217-229
Deregulation of cap-dependent translation has been implicated in the malignant transformation of numerous human tissues. 4EGI-1, a novel small-molecule inhibitor of cap-dependent translation, disrupts formation of the eukaryotic initiation factor 4F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405530545bdd00cb63cc8a64950c5cf9
https://doi.org/10.1007/s10637-017-0535-z
https://doi.org/10.1007/s10637-017-0535-z
Autor:
Robert A. Kratzke, Joe Jay-Dixon, Jeremy Drees, Ahad A. Sadiq, Stephen J. Russell, Manish R. Patel, Blake A. Jacobson, Shaogeng Tang, Brent S. Sorenson
Publikováno v:
Oncotarget
Malignant mesothelioma has a poor prognosis for which there remains an urgent need for successful treatment approaches. Infection with the Edmonston vaccine strain (MV-Edm) derivative of measles virus results in lysis of cancer cells and has been tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5350f8a57319533e1c06ff3102c8265a
https://doi.org/10.18632/oncotarget.18656
https://doi.org/10.18632/oncotarget.18656
Autor:
Zeeshan, Ahmad, Blake A, Jacobson, Mitchell W, McDonald, Nicolas, Vattendahl Vidal, Gabriel, Vattendahl Vidal, Sierra, Chen, Maxwell, Dillenburg, Aniekan M, Okon, Manish R, Patel, Carston R, Wagner, Robert A, Kratzke
Publikováno v:
Cancer chemotherapy and pharmacology. 85(2)
Activated cap-dependent translation promotes cancer by stimulating translation of mRNAs encoding malignancy-promoting proteins. The nucleoside monophosphate Protide, 4Ei-10, undergoes intracellular uptake and conversion by Hint1 to form 7-Cl-Ph-Ethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8639854fce3ee1ca4dbf0a35332b9723
https://pubmed.ncbi.nlm.nih.gov/31974652
https://pubmed.ncbi.nlm.nih.gov/31974652
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e9cc4f6a101ba9b5d95e7c8924b5faa
https://doi.org/10.1096/fasebj.2020.34.s1.00506
https://doi.org/10.1096/fasebj.2020.34.s1.00506