Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Blaise M. Costa"'
Autor:
Seth C. Boehringer, Tullia V. Johnston, Lina Cortez Kwapisz, Pamela J. VandeVord, Blaise M. Costa
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 3, Pp n/a-n/a (2023)
Abstract The NMDA subtype of glutamate receptor serves as an attractive drug target for the treatment of disorders evolving from hyper‐ or hypoglutamatergic conditions. Compounds that optimize the function of NMDA receptors are of great clinical si
Externí odkaz:
https://doaj.org/article/bf9ddc7068374ce594afa09b45a6747c
Autor:
Blaise M. Costa
Publikováno v:
F1000Research, Vol 10 (2021)
N-Methyl-D-aspartate (NMDA) subtype of glutamate receptors is expressed in the human lungs and central nervous system. NMDA receptor potentiation could increase calcium ion influx and promote downstream signaling mechanisms associated with cellular c
Externí odkaz:
https://doaj.org/article/4b05eb595f5c4f11ae179da02d1ee127
A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neurons
Autor:
Blaise M. Costa, Lina Cortés Kwapisz, Brittney Mehrkens, Douglas N. Bledsoe, Bryanna N. Vacca, Tullia V. Johnston, Rehan Razzaq, Dhanasekaran Manickam, Bradley G. Klein
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
Abstract Precisely controlled synaptic glutamate concentration is essential for the normal function of the N‐methyl D‐aspartate (NMDA) receptors. Atypical fluctuations in synaptic glutamate homeostasis lead to aberrant NMDA receptor activity that
Externí odkaz:
https://doaj.org/article/af4e8464cbf4484c997b749172315022
Autor:
Douglas Bledsoe, Ceyhun Tamer, Ivana Mesic, Christian Madry, Bradley G. Klein, Bodo Laube, Blaise M. Costa
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
N-methyl D-aspartate receptors (NMDAR) play crucial role in normal brain function and pathogenesis of neurodegenerative and psychiatric disorders. Functional tetra-heteromeric NMDAR contains two obligatory GluN1 subunits and two identical or differen
Externí odkaz:
https://doaj.org/article/20aef99d51994890a5f738536e18bb13
Autor:
Neil Bannister, R. Rothärmel, Zuner A. Bortolotto, Shashank M. Dravid, Rachael Ingram, Guangyu Fang, Graham L. Collingridge, Kiran Sapkota, A. Volianskis, John Georgiou, Divyan Chopra, Blaise M. Costa, Erica S. Burnell, Mark W. Irvine, David E. Jane, Daniel T. Monaghan, Adina T. Michael-Titus, R. Volianskis
Publikováno v:
Neuropharmacology
Different types of memory are thought to rely on different types of synaptic plasticity, many of which depend on the activation of the N-Methyl-D Aspartate (NMDA) subtype of glutamate receptors. Accordingly, there is considerable interest in the poss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9d736cdd516f56b3b2f54ce83ee476
https://hdl.handle.net/10919/111856
https://hdl.handle.net/10919/111856
Autor:
Michael Mykins, Richard Helm, Stuart S. Berr, Blaise M. Costa, Douglas Bledsoe, Tyler Lucas, Todd A. Sasser, Bradley G. Klein, Hope Tobey, Caroline Campbell, Per Gunnar Brolinson
Publikováno v:
J Am Osteopath Assoc
Context In the aging brain, reduction in the pulsation of cerebral vasculature and fluid circulation causes impairment in the fluid exchange between different compartments and lays a foundation for the neuroinflammation that results in Alzheimer dise
Autor:
Rehan Razzaq, Bradley G. Klein, Blaise M. Costa, Tullia V. Johnston, Bryanna N. Vacca, Douglas N. Bledsoe, Dhanasekaran Manickam, Lina Cortés Kwapisz, Brittney Mehrkens
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
Precisely controlled synaptic glutamate concentration is essential for the normal function of the N‐methyl D‐aspartate (NMDA) receptors. Atypical fluctuations in synaptic glutamate homeostasis lead to aberrant NMDA receptor activity that results
Publikováno v:
European Journal of Pharmacology. 844:216-224
N-methyl D-aspartate (NMDA) receptors play a crucial role in normal brain function, pathogenesis of neurodegenerative and psychiatric disorders. Functional tetra-heteromeric NMDA receptor contains two obligatory GluN1 subunits and two identical or di
Autor:
Ramu Anandakrishnan, Hope Tobey, Steven Nguyen, Osscar Gonzalez Sandoval, Bradley G. Klein, Blaise M. Costa
Age dependent dementia is a devastating disorder afflicting the growing older population around the world. Although pharmacological agents improve symptoms of dementia, age related co-morbidities combined with adverse effects often outweigh their cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9afe7a267bbbae88ada7bc345a0301db
https://doi.org/10.21203/rs.3.rs-96274/v1
https://doi.org/10.21203/rs.3.rs-96274/v1
Autor:
Ramu Anandakrishnan, Hope Tobey, Steven Nguyen, Osscar Gonzalez Sandoval, Bradley G. Klein, Blaise M. Costa
Age dependent dementia is a devastating disorder afflicting the growing older population around the world. Although pharmacological agents improve symptoms of dementia, age related co-morbidities combined with adverse effects often outweigh their cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::879b05c57d6bb4f5829e5eda7fc9ed3a
https://doi.org/10.21203/rs.3.rs-76112/v1
https://doi.org/10.21203/rs.3.rs-76112/v1