Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

Autor: Meetali Singh, Eric Cornes, Blaise Li, Piergiuseppe Quarato, Loan Bourdon, Florent Dingli, Damarys Loew, Simone Proccacia, Germano Cecere

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA regu

Externí odkaz: https://doaj.org/article/803ff8b52d0a47a39490fc9e92339e3c

MicroRNA-Dependent Transcriptional Silencing of Transposable Elements in Drosophila Follicle Cells.

Autor: Bruno Mugat, Abdou Akkouche, Vincent Serrano, Claudia Armenise, Blaise Li, Christine Brun, Tudor A Fulga, David Van Vactor, Alain Pélisson, Séverine Chambeyron

Publikováno v: PLoS Genetics, Vol 11, Iss 5, p e1005194 (2015)

RNA interference-related silencing mechanisms concern very diverse and distinct biological processes, from gene regulation (via the microRNA pathway) to defense against molecular parasites (through the small interfering RNA and the Piwi-interacting R

Externí odkaz: https://doaj.org/article/fdfe3febb61a42029693c27cbaa78fbf

BioConvert: a comprehensive format converter for life sciences

Autor: Hugo Caro, Sulyvan Dollin, Anne Biton, Bryan Brancotte, Dimitri Desvillechabrol, Yoann Dufresne, Blaise Li, Etienne Kornobis, Frédéric Lemoine, Nicolas Maillet, Amandine Perrin, Nicolas Traut, Bertrand Néron, Thomas Cokelaer

Bioinformatics is a field known for the numerous standards and formats that have been developed over the years. This plethora of formats, sometimes complementary, and often redundant, poses many challenges to bioinformatics data analysts. They consta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7a2cefc8b4c2ab1f4662fb4c9d396e
https://doi.org/10.1101/2023.03.13.532455

Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants

Autor: Blaise Li, Martino Ugolini, Damarys Loew, Germano Cecere, Aleksei Samolygo, Céline Didier, Eric Cornes, Meetali Singh, Giorgia Barucci, Piergiuseppe Quarato, Florent Dingli

Publikováno v: Nature cell biology
Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2020, 22 (2), pp.235-245. ⟨10.1038/s41556-020-0462-7⟩
Nature Cell Biology, 2020, 22 (2), pp.235-245. ⟨10.1038/s41556-020-0462-7⟩

International audience; PIWI-interacting RNAs (piRNAs) promote fertility in many animals. However, whether this is due to their conserved role in repressing repetitive elements (REs) remains unclear. Here, we show that the progressive loss of fertili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983b418c96155c11b9d0637d29c2e4f8
https://doi.org/10.1038/s41556-020-0462-7

Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

Autor: Germano Cecere, Meetali Singh, Eric Cornes, Blaise Li, Piergiuseppe Quarato, Loan Bourdon, Florent Dingli, Damarys Loew, Simone Procaccia

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.3492. ⟨10.1038/s41467-021-23615-w⟩
Nature Communications, 2021, 12 (1), pp.3492. ⟨10.1038/s41467-021-23615-w⟩
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

In the Caenorhabditis elegans germline, thousands of mRNAs are concomitantly expressed with antisense 22G-RNAs, which are loaded into the Argonaute CSR-1. Despite their essential functions for animal fertility and embryonic development, how CSR-1 22G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dda9c98bb797671190a089b658cbcda
https://hal-pasteur.archives-ouvertes.fr/pasteur-03258520/file/s41467-021-23615-w.pdf