Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

Autor: Meetali Singh, Eric Cornes, Blaise Li, Piergiuseppe Quarato, Loan Bourdon, Florent Dingli, Damarys Loew, Simone Proccacia, Germano Cecere

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA regu

Externí odkaz: https://doaj.org/article/803ff8b52d0a47a39490fc9e92339e3c

Queuosine modification of tRNA-Tyrosine elicits translational reprogramming and enhances growth of Vibrio cholerae with aminoglycosides

Autor: Louna Fruchard, Anamaria Babosan, Andre Carvalho, Manon Lang, Blaise Li, Magalie Duchateau, Quentin Giai-Gianetto, Mariette Matondo, Frédéric Bonhomme, Céline Fabret, Olivier Namy, Valérie de Crécy-Lagard, Didier Mazel, Zeynep Baharoglu

Tgt is the enzyme modifying the guanine (G) in tRNAs with GUN anti-codon to queuosine (Q). tgt is required for optimal growth of Vibrio cholerae in the presence of sub-lethal aminoglycoside concentrations. We further explored here the role of the Q i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6837037e6cab2b39f4aab1754ab4dd9e
https://hal-pasteur.archives-ouvertes.fr/pasteur-04093412/file/2022.09.26.509455.full.pdf

Leishmania allelic selection during experimental sand fly infection correlates with mutational signatures of oxidative DNA damage

Autor: Giovanni Bussotti, Blaise Li, Pascale Pescher, Barbora Vojtkova, Isabelle Louradour, Katerina Pruzinova, Jovana Sadlova, Petr Volf, Gerald F. Späth

Trypanosomatid pathogens are transmitted by blood-feeding insects, causing devastating human infections. Survival of these parasites in their vertebrate and invertebrate hosts relies on their capacity to differentiate into distinct stages that are th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fede30734ea894e05a81a643fc045561
https://doi.org/10.1101/2022.05.02.490304

piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development

Autor: Eric, Cornes, Loan, Bourdon, Meetali, Singh, Florian, Mueller, Piergiuseppe, Quarato, Erik, Wernersson, Magda, Bienko, Blaise, Li, Germano, Cecere

Publikováno v: Developmental cell. 57(2)

Eukaryotic genomes harbor invading transposable elements that are silenced by PIWI-interacting RNAs (piRNAs) to maintain genome integrity in animal germ cells. However, whether piRNAs also regulate endogenous gene expression programs remains unclear.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ce3e8e28999163db0f65c1ef77bc45b2
https://pubmed.ncbi.nlm.nih.gov/35077678

Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

Autor: Germano Cecere, Meetali Singh, Eric Cornes, Blaise Li, Piergiuseppe Quarato, Loan Bourdon, Florent Dingli, Damarys Loew, Simone Procaccia

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.3492. ⟨10.1038/s41467-021-23615-w⟩
Nature Communications, 2021, 12 (1), pp.3492. ⟨10.1038/s41467-021-23615-w⟩
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

In the Caenorhabditis elegans germline, thousands of mRNAs are concomitantly expressed with antisense 22G-RNAs, which are loaded into the Argonaute CSR-1. Despite their essential functions for animal fertility and embryonic development, how CSR-1 22G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dda9c98bb797671190a089b658cbcda
https://hal-pasteur.archives-ouvertes.fr/pasteur-03258520/file/s41467-021-23615-w.pdf