Clinical outcome and biomarker assessments of a multi-centre phase II trial assessing niraparib with or without dostarlimab in recurrent endometrial carcinoma

Autor: Ainhoa Madariaga, Swati Garg, Nairi Tchrakian, Neesha C. Dhani, Waldo Jimenez, Stephen Welch, Helen MacKay, Josee-Lyne Ethier, Lucy Gilbert, Xuan Li, Angela Rodriguez, Lucy Chan, Valerie Bowering, Blaise Clarke, Tong Zhang, Ian King, Gregory Downs, Tracy Stockley, Lisa Wang, Smitha Udagani, Amit M. Oza, Stephanie Lheureux

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)

Treatment options in patients with recurrent endometrial carcinoma (EC) are limited and response rates to chemotherapy are poor. Here the authors report the results of a phase II trial of niraparib (PARP inhibitor) monotherapy or in combination with

Externí odkaz: https://doaj.org/article/996af268f73e4c3ab512d6bbc02ef4fa

Tumor and germline next generation sequencing in high grade serous cancer: experience from a large population‐based testing program

Autor: Melanie Care, Jeanna McCuaig, Blaise Clarke, Sylvie Grenier, Raymond H Kim, Marjan Rouzbahman, Natalie Stickle, Marcus Q Bernardini, Tracy L. Stockley

Publikováno v: Molecular Oncology, Vol 15, Iss 1, Pp 80-90 (2021)

The aim of this study was to determine the prevalence of somatic and germline pathogenic variants (PVs) in high‐grade serous cancer (HGSC) and to demonstrate the technical feasibility and effectiveness of a large‐scale, population‐based tumor t

Externí odkaz: https://doaj.org/article/cd104b9b725b418b9089d7cf78c664d6

Variability in endometrial carcinoma pathology practice: opportunities for improvement with molecular classification

Autor: Emily F. Thompson, Jutta Huvila, Amy Jamieson, Samuel Leung, Amy Lum, Saul Offman, Alice Lytwyn, Mona Lisa Sur, Lynn Hoang, Julie Irving, Nicholas van der Westhuizen, Chantale Morin, Cyrille Bicamumpaka, Nazilla Azordegan, François Gougeon, Kaoutar Ennour-Idrissi, Janine Senz, Melissa K. McConechy, Rosalia Aguirre-Hernandez, Victoria Lui, Carolyn Kuo, Cassidy Bell, Taylor Salisbury, James Lawson, Ellen He, Shanzhao Wang, Derek Chiu, Sarah Kean, Vanessa Samouëlian, Shannon Salvador, Walter Gotlieb, Limor Helpman, Stephanie Scott, Christoph Wohlmuth, Danielle Vicus, Marie Plante, Aline Talhouk, David Huntsman, Carlos Parra-Herran, Mary Kinloch, Katherine Grondin, C. Blake Gilks, Jessica N. McAlpine, Jessica McAlpine, Anita Agrawal, Omar Al-Nourhji, Alon Altman, Marcus Bernardini, C. Bicamumpaka, Mark Carey, Blaise Clarke, Nazila Azordegan, Bojana Djordjevic, Laurie Elit, Alex Ferenczy, Sarah Finlayson, Anthony Fyles, Hugo Garneau, France Gauthier, Prafull Ghatage, Blake Gilks, Kathy Han, Hal Hirte, Fleur Huang, Katharina Kieser, Mary Kinlloch, Iwa Kong, Aalok Kumar, Janice Kwon, Sandra Lee, Eric Leung, Helen Mackay, Eve-Lyne Marchand, Justin Mcginnis, Dianne Miller, Gregg Nelson, Manuela Pelmus, Annick Pina, Anna Plotkin, Diane Provencher, Anna Tinker, Alicia Tone, Stephen Welch, Nicholas Westhuizen, Katarzyna Jerzak

Publikováno v: Modern Pathology. 35:1974-1982

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21ba941ca766a49ef2842e5b6df53618
https://doi.org/10.1038/s41379-022-01165-w

FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism

Autor: Cristal M. Hill, Thomas Laeger, Madeleine Dehner, Diana C. Albarado, Blaise Clarke, Desiree Wanders, Susan J. Burke, J. Jason Collier, Emily Qualls-Creekmore, Samantha M. Solon-Biet, Stephen J. Simpson, Hans-Rudolf Berthoud, Heike Münzberg, Christopher D. Morrison

Publikováno v: Cell Reports, Vol 27, Iss 10, Pp 2934-2947.e3 (2019)

Summary: Reduced dietary protein intake induces adaptive physiological changes in macronutrient preference, energy expenditure, growth, and glucose homeostasis. We demonstrate that deletion of the FGF21 co-receptor βKlotho (Klb) from the brain produ

Externí odkaz: https://doaj.org/article/fbc23e92f7fb44a2b7e2fd673a5fd932

Brief family history questionnaire to screen for Lynch syndrome in women with newly diagnosed non-serous, non-mucinous ovarian cancers

Autor: Soyoun Rachel Kim, Alicia Tone, Raymond Kim, Matthew Cesari, Blaise Clarke, Tae Hart, Melyssa Aronson, Spring Holter, Alice Lytwyn, Manjula Maganti, Leslie Oldfield, Steven Gallinger, Marcus Q Bernardini, Amit M Oza, Bojana Djordjevic, Jordan Lerner-Ellis, Emily Van de Laar, Danielle Vicus, Trevor J Pugh, Aaron Pollett, Sarah Elizabeth Ferguson, Lua Eiriksson

Publikováno v: International Journal of Gynecologic Cancer. 32:891-898

ObjectivesWhile ovarian cancer is the third most common Lynch syndrome-associated cancer in women, there is no established screening strategy to identify Lynch syndrome in this population. The objective of this study was to assess whether the 4-item

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed229a3baa8a8b50d01c28ada4d32d99
https://doi.org/10.1136/ijgc-2021-003082