Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Blaire Cooke"'
Autor:
Joanne Bowen, Sofia Braga, Valeria Dal Zotto, John Finnie, Daniel DiPrimeo, Blaire Cooke, Georg F. Bischof, Alvin Wong, Jack A. Di Palma
Publikováno v:
Physiological Reports, Vol 12, Iss 16, Pp n/a-n/a (2024)
Abstract The irreversible pan‐HER tyrosine kinase inhibitor neratinib is approved for patients with HER2‐positive, early‐stage and metastatic breast cancer (BC). Neratinib‐associated diarrhea is the most common reason for early discontinuatio
Externí odkaz:
https://doaj.org/article/4ac23f911fbd43ba915c155b47741514
Autor:
Elizabeth Olek, Kiana Keyvanjah, Jane Liang, Igor Rubets, Blaire Cooke, Alvin Wong, Daniel Di Primeo, Laura Sterling, David Martin
Publikováno v:
Cancer Chemotherapy and Pharmacology. 84:1125-1132
To evaluate the effects of multiple doses of loperamide on the pharmacokinetics and safety of a single oral dose of neratinib. This was an open-label, two-period, fixed-sequence study. Twenty healthy adult subjects received an oral dose of neratinib
Autor:
Stephen Uy, Brian Smith, Evan A. Stein, Scott M. Wasserman, Caroline Crispino, Clapton Dias, Alexander Colbert, Marc W. Retter, Mark Matson, Blaire Cooke, Maurice Emery, Adam J. Shaywitz, John P. Gibbs, Dina Stolman, Karen Smirnakis, Bing Gao
Publikováno v:
Journal of the American College of Cardiology. 60:1888-1898
Objectives: The aim of this study was to evaluate the safety, tolerability, and effects of AMG 145 on low-density lipoprotein cholesterol (LDL-C) in healthy and hypercholesterolemic subjects on sta...
Autor:
Joan T. Merrill, Erik Rasmussen, Donna Holloway, Jill P. Buyon, Daniel J. Wallace, John Ferbas, Wayne Tsuji, Blaire Cooke, Tsui Chern Cheah, Ellen M. Ginzler, Kameswara Rao V. Kuchimanchi, Michael H. Weisman, William Stohl, Shelley Sims Belouski, R. John Looney, Arunan Kaliyaperumal, Debra Zack
Publikováno v:
Arthritis Research & Therapy
Blisibimod is a potent B cell-activating factor (BAFF) antagonist that binds to both cell membrane-expressed and soluble BAFF. The goal of these first-in-human studies was to characterize the safety, tolerability, and pharmacokinetic and pharmacodyna
Publikováno v:
Clinical pharmacokinetics. 45(5)
Anaemia is a major and persistent manifestation of chronic kidney disease (CKD) caused by the deficient production of erythropoietin in the kidneys, the prevalence of which is proportional to the deterioration in kidney function. Darbepoetin alfa, an
Autor:
Stephen Uy, Caroline Crispino, Bing Gao, Scott M. Wasserman, Karen Smirnakis, Ren Xu, Mark Matson, Dina Stolman, Blaire Cooke, Maurice Emery, Clapton Dias, Adam J. Shaywitz, Brian H. Smith, Marc W. Retter, Evan A. Stein, Alexander Colbert, John P. Gibbs
Publikováno v:
Journal of Clinical Lipidology. 6:286-287
Autor:
Stephen Uy, Maurice Emery, Karen Smirnakis, Blaire Cooke, Adam J. Shaywitz, Brian Smith, John P. Gibbs, Scott M. Wasserman, Evan A. Stein, Clapton Dias, Caroline Crispino, Bing Gao
Publikováno v:
Journal of the American College of Cardiology. (13):E1379
Proprotein convertase subtilisin/kexin type 9 (PCSK9) downregulates surface expression of the low density lipoprotein (LDL) receptor (LDL-R), increasing circulating LDL cholesterol (LDL-C). Statins increase LDL-R and PCSK9 levels. AMG 145, a fully hu
Autor:
Simon Jackson, Brian Smith, Blaire Cooke, Ren Xu, Adam J. Shaywitz, Scott M. Wasserman, Clapton Dias, Dan Fitzpatrick, Lisa Hamilton, Matt Peach, Rob Scott, Bing Gao
Publikováno v:
Journal of the American College of Cardiology. (12):A1378