Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Blair T, Lapointe"'
Autor:
David A. Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Gunaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A. Piesvaux, Karin M. Otte, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
Publikováno v:
Journal of Medicinal Chemistry. 65:16801-16817
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::365ba0e1a6a6d085b4344b637344b726
https://doi.org/10.1021/acs.jmedchem.2c01605
https://doi.org/10.1021/acs.jmedchem.2c01605
Autor:
David A, Candito, Vladimir, Simov, Anmol, Gulati, Solomon, Kattar, Ryan W, Chau, Blair T, Lapointe, Joey L, Methot, Duane E, DeMong, Thomas H, Graham, Ravi, Kurukulasuriya, Mitchell H, Keylor, Ling, Tong, Gregori J, Morriello, John J, Acton, Barbara, Pio, Weiguo, Liu, Jack D, Scott, Michael J, Ardolino, Theodore A, Martinot, Matthew L, Maddess, Xin, Yan, Hakan, Gunaydin, Rachel L, Palte, Spencer E, McMinn, Lisa, Nogle, Hongshi, Yu, Ellen C, Minnihan, Charles A, Lesburg, Ping, Liu, Jing, Su, Laxminarayan G, Hegde, Lily Y, Moy, Janice D, Woodhouse, Robert, Faltus, Tina, Xiong, Paul, Ciaccio, Jennifer A, Piesvaux, Karin M, Otte, Matthew E, Kennedy, David Jonathan, Bennett, Erin F, DiMauro, Matthew J, Fell, Santhosh, Neelamkavil, Harold B, Wood, Peter H, Fuller, J Michael, Ellis
Publikováno v:
Journal of medicinal chemistry. 65(24)
Inhibition of leucine-rich repeat kinase 2 (LRRK2) kinase activity represents a genetically supported, chemically tractable, and potentially disease-modifying mechanism to treat Parkinson's disease. Herein, we describe the optimization of a novel ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1e71dbb505d333749f04ff7e2a07818
https://pubmed.ncbi.nlm.nih.gov/36475697
https://pubmed.ncbi.nlm.nih.gov/36475697
Autor:
Matthew H. Daniels, Sunil Nagpal, Blair T. Lapointe, Jos Cals, Mario van der Stelt, Vladimir Simov, Willem Jan Karstens, Sujal V. Deshmukh, Kenneth Jay Barr, J. Richard Miller, Hans van Eenenaam, Craig C. Correll, John Maclean, Laxminarayan G Hegde, Lily Y. Moy, B. Wesley Trotter, Rachel L. Palte, Janice D Woodhouse, Nunzio Sciammetta, Gopal Parthasarathy, Heidi Ferguson, Rita Azevedo, Hongjun Zhang, Arthur Oubrie, Neville J. Anthony
Publikováno v:
ACS Medicinal Chemistry Letters. 11:114-119
The clinical success of anti-IL-17 monoclonal antibodies (i.e., Cosentyx and Taltz) has validated Th17 pathway modulation for the treatment of autoimmune diseases. The nuclear hormone receptor RORγt is a master regulator of Th17 cells and affects th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927a9a20903f38d39770d2e5897d3e47
https://doi.org/10.1021/acsmedchemlett.9b00431
https://doi.org/10.1021/acsmedchemlett.9b00431
Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors
Autor:
Blair T. Lapointe, Jack D. Scott, Xin Cindy Yan, Haiqun Tang, Janice D Woodhouse, Kaleen Konrad Childers, Robert Faltus, Erin F. DiMauro, Solomon Kattar, Charles S. Yeung, Ravi Kurukulasuriya, Vladimir Simov, Hakan Gunaydin, Anmol Gulati, Joey L. Methot, Rachel L. Palte, Ellen C. Minnihan, Greg Morriello, J. Michael Ellis, Harold B. Wood, Santhosh Neelamkavil, Karin M. Otte, Michael J. Ardolino, Barbara Pio, Ping Liu, Laxminarayan G Hegde, Matthew J. Fell, Vanessa L. Rada, Peter Fuller, Paul J Ciaccio
Publikováno v:
RSC Med Chem
The discovery of potent, kinome selective, brain penetrant LRRK2 inhibitors is the focus of extensive research seeking new, disease-modifying treatments for Parkinson's disease (PD). Herein, we describe the discovery and evolution of a picolinamide-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8d45ea7dd7adda70471298a4476afa
https://europepmc.org/articles/PMC8292993/
https://europepmc.org/articles/PMC8292993/
Autor:
Hakan Gunaydin, Scott A. Johnson, Brian R. Lahue, Blair T. Lapointe, J. Michael Ellis, Michael D. Altman, Peter Fuller
Publikováno v:
ACS Medicinal Chemistry Letters. 9:528-533
[Image: see text] Preclinical optimization of compounds toward viable drug candidates requires an integrated understanding of properties that impact predictions of the clinically efficacious dose. The importance of optimizing half-life, unbound clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60921a58f824cb5af8f2a1fc42b5a38
https://doi.org/10.1021/acsmedchemlett.8b00018
https://doi.org/10.1021/acsmedchemlett.8b00018
Autor:
Hongjun, Zhang, Blair T, Lapointe, Neville, Anthony, Rita, Azevedo, Jos, Cals, Craig C, Correll, Matthew, Daniels, Sujal, Deshmukh, Hans, van Eenenaam, Heidi, Ferguson, Laxminarayan G, Hegde, Willem Jan, Karstens, John, Maclean, J Richard, Miller, Lily Y, Moy, Vladimir, Simov, Sunil, Nagpal, Arthur, Oubrie, Rachel L, Palte, Gopal, Parthasarathy, Nunzio, Sciammetta, Mario, van der Stelt, Janice D, Woodhouse, B Wesley, Trotter, Kenneth, Barr
Publikováno v:
ACS Med Chem Lett
[Image: see text] The clinical success of anti-IL-17 monoclonal antibodies (i.e., Cosentyx and Taltz) has validated Th17 pathway modulation for the treatment of autoimmune diseases. The nuclear hormone receptor RORγt is a master regulator of Th17 ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b04108fd54b05ba3642d5229b4061176
https://pubmed.ncbi.nlm.nih.gov/32071676
https://pubmed.ncbi.nlm.nih.gov/32071676
Autor:
Yudith Garcia, Joon Jung, Craig R. Gibeau, Blair T. Lapointe, Rafael Fernandez, Sujal V. Deshmukh, Vladimir Simov, Jason D. Katz, Brian Kraybill, Sangita B. Patel, Jonathan R. Young, Hua Su, Fiona Elwood, Hakan Gunaydin, Tony Siu, Christopher J. Dinsmore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1803-1808
The mammalian Janus Kinases (JAK1, JAK2, JAK3 and TYK2) are intracellular, non-receptor tyrosine kinases whose activities have been associated in the literature and the clinic with a variety of hyperproliferative diseases and immunological disorders.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa15f53b86f2a0d4fb3ef6e2917ad01
https://doi.org/10.1016/j.bmcl.2016.02.035
https://doi.org/10.1016/j.bmcl.2016.02.035
Publikováno v:
ChemInform. 41
A bench-stable potassium trifluoroborate enol ether reagent has been prepared. This reagent is suitable for the incorporation of 2,2-difluoroenolethers into aryl and heteroaryl systems via palladium-mediated cross-coupling with suitable halide coupli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6754f9c717206a63c7232f7412317084
https://doi.org/10.1002/chin.201013184
https://doi.org/10.1002/chin.201013184
Publikováno v:
The Journal of organic chemistry. 74(22)
A bench-stable potassium trifluoroborate enol ether reagent has been prepared. This reagent is suitable for the incorporation of 2,2-difluoroenolethers into aryl and heteroaryl systems via palladium-mediated cross-coupling with suitable halide coupli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e7a010fb7a9029e8f0f099850ba326
https://pubmed.ncbi.nlm.nih.gov/19845317
https://pubmed.ncbi.nlm.nih.gov/19845317