Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Blair Ney"'
Autor:
Ghader Bashiri, James Antoney, Ehab N. M. Jirgis, Mihir V. Shah, Blair Ney, Janine Copp, Stephanie M. Stuteley, Sreevalsan Sreebhavan, Brian Palmer, Martin Middleditch, Nobuhiko Tokuriki, Chris Greening, Colin Scott, Edward N. Baker, Colin J. Jackson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Cofactor F420 plays crucial roles in bacterial and archaeal metabolism, but its biosynthetic pathway is not fully understood. Here, the authors present the structure of one of the enzymes and provide experimental evidence for a substantial revision o
Externí odkaz:
https://doaj.org/article/dfc85bab35bc45cdb9ec5b52911c6873
Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria
Autor:
Rhys Grinter, Blair Ney, Rajini Brammananth, Christopher K. Barlow, Paul R. F. Cordero, David L. Gillett, Thierry Izoré, Max J. Cryle, Liam K. Harold, Gregory M. Cook, George Taiaroa, Deborah A. Williamson, Andrew C. Warden, John G. Oakeshott, Matthew C. Taylor, Paul K. Crellin, Colin J. Jackson, Ralf B. Schittenhelm, Ross L. Coppel, Chris Greening
Publikováno v:
mSystems, Vol 5, Iss 3 (2020)
ABSTRACT F420 is a low-potential redox cofactor used by diverse bacteria and archaea. In mycobacteria, this cofactor has multiple roles, including adaptation to redox stress, cell wall biosynthesis, and activation of the clinical antitubercular prodr
Externí odkaz:
https://doaj.org/article/b31841d86def486ba529324116760dbf
Autor:
Blair Ney, Carlo R. Carere, Richard Sparling, Thanavit Jirapanjawat, Matthew B. Stott, Colin J. Jackson, John G. Oakeshott, Andrew C. Warden, Chris Greening
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
F420 is a microbial cofactor that mediates a wide range of physiologically important and industrially relevant redox reactions, including in methanogenesis and tetracycline biosynthesis. This deazaflavin comprises a redox-active isoalloxazine headgro
Externí odkaz:
https://doaj.org/article/8fdbefb240e94075a13a6913a4db3a74
Autor:
Chris Greening, Thanavit Jirapanjawat, Shahana Afroze, Blair Ney, Colin Scott, Gunjan Pandey, Brendon M. Lee, Robyn J. Russell, Colin J. Jackson, John G. Oakeshott, Matthew C. Taylor, Andrew C. Warden
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
An unusual aspect of actinobacterial metabolism is the use of the redox cofactor F420. Studies have shown that actinobacterial F420H2-dependent reductases promiscuously hydrogenate diverse organic compounds in biodegradative and biosynthetic processe
Externí odkaz:
https://doaj.org/article/9c3eee481f1c46efab8c6eb800289757
Autor:
Dhamidhu Eratne, Luke J. Ney, Blair Ney, Qiao-Xin Li, Victoria Lewis, Dennis Velakoulis, Steven J. Collins, Christiane Stehmann
Publikováno v:
Molecular Neurobiology. 58:3983-3991
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of CJD and is believed to be caused by the misfolding and aggregation of endogenous prion protein. Several classification systems have been developed to correlate the molecular charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c3ddac9cd7d59a4a04711bed0150a7
https://doi.org/10.1007/s12035-021-02396-9
https://doi.org/10.1007/s12035-021-02396-9
Autor:
Dhamidhu, Eratne, Samantha M, Loi, Qiao-Xin, Li, Christiane, Stehmann, Charles B, Malpas, Alexander, Santillo, Shorena, Janelidze, Claire, Cadwallader, Nirbaanjot, Walia, Blair, Ney, Victoria, Lewis, Matteo, Senesi, Christopher, Fowler, Amelia, McGlade, Shiji, Varghese, Parsa, Ravanfar, Wendy, Kelso, Sarah, Farrand, Michael, Keem, Matthew, Kang, Anita M Y, Goh, Kunal, Dhiman, Veer, Gupta, Rosie, Watson, Nawaf, Yassi, Cath, Kaylor-Hughes, Richard, Kanaan, Piero, Perucca, Hannah, Dobson, Lucy, Vivash, Rashida, Ali, Terence J, O'Brien, Oskar, Hansson, Henrik, Zetterberg, Kaj, Blennow, Mark, Walterfang, Colin L, Masters, Samuel F, Berkovic, Steven, Collins, Dennis, Velakoulis
Publikováno v:
Alzheimer'sdementia : the journal of the Alzheimer's AssociationREFERENCES. 18(11)
Many patients with cognitive and neuropsychiatric symptoms face diagnostic delay and misdiagnosis. We investigated whether cerebrospinal fluid (CSF) neurofilament light (NfL) and total-tau (t-tau) could assist in the clinical scenario of differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e49cd096a0330990e6e1a54675de879
https://pubmed.ncbi.nlm.nih.gov/35102694
https://pubmed.ncbi.nlm.nih.gov/35102694
Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria
Autor:
Blair Ney, Christopher K. Barlow, Rajini Brammananth, Ross L. Coppel, Paul K. Crellin, Matthew C. Taylor, David L. Gillett, Gregory M. Cook, Colin J. Jackson, Ralf B. Schittenhelm, Liam K. Harold, Max J. Cryle, Rhys Grinter, Andrew C. Warden, John G. Oakeshott, Thierry Izoré, George Taiaroa, Paul R. F. Cordero, Deborah A Williamson, Chris Greening
Publikováno v:
mSystems
mSystems, Vol 5, Iss 3 (2020)
mSystems, Vol 5, Iss 3, p e00389-20 (2020)
mSystems, Vol 5, Iss 3 (2020)
mSystems, Vol 5, Iss 3, p e00389-20 (2020)
Mycobacteria are major environmental microorganisms and cause many significant diseases, including tuberculosis. Mycobacteria make an unusual vitamin-like compound, F420, and use it to both persist during stress and resist antibiotic treatment. Under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73a5531a578cf3b1b1945c0e93d753f
http://europepmc.org/articles/PMC7253369
http://europepmc.org/articles/PMC7253369
Autor:
Stephen J Watt, Carlo R Carere, Sergio E. Morales, Chris Greening, Matthew C. Taylor, Gunjan Pandey, John G. Oakeshott, Matthew B. Stott, Andrew C. Warden, Colin J. Jackson, F. Hafna Ahmed, Ambarish Biswas, Blair Ney
Publikováno v:
The ISME Journal. 11:125-137
F420 is a low-potential redox cofactor that mediates the transformations of a wide range of complex organic compounds. Considered one of the rarest cofactors in biology, F420 is best known for its role in methanogenesis and has only been chemically i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c955b6aa865a7a7da597ad5da3dcde60
https://doi.org/10.1038/ismej.2016.100
https://doi.org/10.1038/ismej.2016.100
Autor:
Ghader, Bashiri, James, Antoney, Ehab N M, Jirgis, Mihir V, Shah, Blair, Ney, Janine, Copp, Stephanie M, Stuteley, Sreevalsan, Sreebhavan, Brian, Palmer, Martin, Middleditch, Nobuhiko, Tokuriki, Chris, Greening, Colin, Scott, Edward N, Baker, Colin J, Jackson
Publikováno v:
Nature Communications
Cofactor F420 plays critical roles in primary and secondary metabolism in a range of bacteria and archaea as a low-potential hydride transfer agent. It mediates a variety of important redox transformations involved in bacterial persistence, antibioti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25a28507599cbb4ac61c559ab79cc38c
https://pubmed.ncbi.nlm.nih.gov/30952857
https://pubmed.ncbi.nlm.nih.gov/30952857
Autor:
Thanavit Jirapanjawat, Colin J. Jackson, John G. Oakeshott, Chris Greening, Richard Sparling, Matthew B. Stott, Andrew C. Warden, Carlo R Carere, Blair Ney
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Frontiers in Microbiology
Frontiers in Microbiology
F420 is a microbial cofactor that mediates a wide range of physiologically important and industrially relevant redox reactions, including in methanogenesis and tetracycline biosynthesis. This deazaflavin comprises a redox-active isoalloxazine headgro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e510cb93ba87a4342076089e769d3cde
https://doi.org/10.3389/fmicb.2017.01902
https://doi.org/10.3389/fmicb.2017.01902